digitoxin

3-[(3S,5R,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2667
Screen concentration 100.0 μM
Source Microsource (Natural product library)
PubChem CID 5702041
SMILES CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O
Standardized SMILES CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CCC7(C)C(CCC67O)C8=CC(=O)OC8)C4)OC3C)OC2C
Molecular weight 764.9391
ALogP 3.1
H-bond donor count 5
H-bond acceptor count 13
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.47
% growth inhibition (Hom. pool) -2.38


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5702041
Download HIP data (tab-delimited text)  (excel)
Gene:PRP4(YPR178W)|FD-Score:3.75|P-value:8.82E-5|Clearance:0.9||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPT4(YOR259C)|FD-Score:-3.36|P-value:3.84E-4|Clearance:0||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization Gene:PRP4(YPR178W)|FD-Score:3.75|P-value:8.82E-5|Clearance:0.9||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPT4(YOR259C)|FD-Score:-3.36|P-value:3.84E-4|Clearance:0||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5702041
Download HOP data (tab-delimited text)  (excel)
Gene:ATF1(YOR377W)|FD-Score:3.81|P-value:7.03E-5||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:BCK2(YER167W)|FD-Score:3.3|P-value:4.83E-4||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:CWH41(YGL027C)|FD-Score:-3.11|P-value:9.45E-4||SGD DESC:Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress Gene:EMP46(YLR080W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:FMT1(YBL013W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:FRT1(YOR324C)|FD-Score:4.28|P-value:9.22E-6||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:GDS1(YOR355W)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRPL22(YNL177C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NDE1(YMR145C)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:OCA5(YHL029C_p)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PHM6(YDR281C)|FD-Score:-3.41|P-value:3.24E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:QCR6(YFR033C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RAD24(YER173W)|FD-Score:-4.43|P-value:4.81E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RPS22A(YJL190C)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication Gene:RTS1(YOR014W)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SLM6(YBR266C_d)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Gene:SYG1(YIL047C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency Gene:TCB3(YML072C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:TRP4(YDR354W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR074W(YBR074W_p)|FD-Score:-3.33|P-value:4.31E-4||SGD DESC:Putative metalloprotease Gene:YCL001W-A(YCL001W-A_p)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III Gene:YDR008C(YDR008C_d)|FD-Score:3.77|P-value:8.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR194C(YLR194C)|FD-Score:3.88|P-value:5.12E-5||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YMR087W(YMR087W)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YOL036W(YOL036W_p)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication Gene:ATF1(YOR377W)|FD-Score:3.81|P-value:7.03E-5||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:BCK2(YER167W)|FD-Score:3.3|P-value:4.83E-4||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:CWH41(YGL027C)|FD-Score:-3.11|P-value:9.45E-4||SGD DESC:Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress Gene:EMP46(YLR080W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:FMT1(YBL013W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:FRT1(YOR324C)|FD-Score:4.28|P-value:9.22E-6||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:GDS1(YOR355W)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRPL22(YNL177C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NDE1(YMR145C)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:OCA5(YHL029C_p)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PHM6(YDR281C)|FD-Score:-3.41|P-value:3.24E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:QCR6(YFR033C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RAD24(YER173W)|FD-Score:-4.43|P-value:4.81E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RPS22A(YJL190C)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication Gene:RTS1(YOR014W)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SLM6(YBR266C_d)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Gene:SYG1(YIL047C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency Gene:TCB3(YML072C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:TRP4(YDR354W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR074W(YBR074W_p)|FD-Score:-3.33|P-value:4.31E-4||SGD DESC:Putative metalloprotease Gene:YCL001W-A(YCL001W-A_p)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III Gene:YDR008C(YDR008C_d)|FD-Score:3.77|P-value:8.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR194C(YLR194C)|FD-Score:3.88|P-value:5.12E-5||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YMR087W(YMR087W)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YOL036W(YOL036W_p)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR178W3.758.82E-50.90PRP4Splicing factor, component of the U4/U6-U5 snRNP complex
YGL099W2.860.002150.01LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YHR170W2.850.002190.04NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YER159C2.810.002480.18BUR6Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YLR022C2.630.004270.05SDO1Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
YOL038W2.570.005010.08PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YML105C2.490.006330.05SEC65Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
YGR179C2.440.007340.03OKP1Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
YGR090W2.410.008010.10UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YLR276C2.310.010600.05DBP9DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
YOR098C2.260.012000.01NUP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
YPR168W2.250.012200.04NUT2Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
YLR243W_p2.200.013700.05GPN3_pPutative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
YLR347C2.160.015500.02KAP95Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
YDR526C_d2.130.016500.00YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR324C4.289.22E-6FRT1Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
YLR194C3.885.12E-5YLR194CStructural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
YMR087W3.836.40E-5YMR087WPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
YOR377W3.817.03E-5ATF1Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
YDR008C_d3.778.20E-5YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL001W-A_p3.691.13E-4YCL001W-A_pPutative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
YNL177C3.423.12E-4MRPL22Mitochondrial ribosomal protein of the large subunit
YOR014W3.393.44E-4RTS1B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
YDR354W3.354.01E-4TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YBR266C_d3.344.21E-4SLM6_dProtein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase
YER167W3.304.83E-4BCK2Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YML072C3.187.40E-4TCB3Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YOL036W_p3.177.50E-4YOL036W_pProtein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
YLR080W3.177.57E-4EMP46Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YHL029C_p3.148.56E-4OCA5_pCytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts

GO enrichment analysis for SGTC_2667
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1672.21E-38SGTC_2669eugenol 100.0 μMMicrosource (Natural product library)33140.0537634
0.1524.86E-32SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.16129
0.1521.08E-31SGTC_20325185112 26.0 μMChembridge (Fragment library)57181890.05
0.1381.58E-26SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.108108
0.1366.44E-26SGTC_511013-0126 23.4 μMChemDiv (Drug-like library)16278500.0373832
0.1301.43E-23SGTC_2741miltefosine 3.0 μMMiscellaneous35990.0315789
0.1283.89E-23SGTC_24865283202 22.4 μMMiscellaneous13777510.0416667
0.1271.26E-22SGTC_140354-0009 295.0 μMChemDiv (Drug-like library)17135070.0291262
0.1211.19E-20SGTC_2733amorolfine 100.0 μMMiscellaneous542600.0792079plasma membrane duress
0.1202.06E-20SGTC_2678equilin 100.0 μMMicrosource (Natural product library)32470.13
0.1195.27E-20SGTC_24885268135 45.7 μMMiscellaneous12703560.0408163
0.1172.14E-19SGTC_2524avocatin b 10.6 μMMicrosource (Natural product library)67107480.0106383
0.1162.99E-19SGTC_305-(2-thienylidene)-Rhodanine 28.7 μMChemDiv (Drug-like library)12411320.0408163
0.1128.65E-18SGTC_5423381-0244 89.3 μMChemDiv (Drug-like library)11128430.0560748
0.1103.28E-17SGTC_1801486-1293 102.8 μMChemDiv (Drug-like library)41405360.0350877

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2563tomatine8.54 μM0.256708777Microsource (Natural product library)994.12426-2.3131322
SGTC_1572epiandrosterone68.9 μM0.241379441302TimTec (Pure natural product library)290.44033.58812
SGTC_2540epiandrosterone100 μM0.241379441302TimTec (Pure natural product library)290.44033.58812
SGTC_2584androsterone48.74 μM0.2413792754130Microsource (Natural product library)290.44033.58812cell wall
SGTC_266formosanin C406 nM0.22047273597Miscellaneous1015.184780.311020sphingolipid biosynthesis & PDR1
SGTC_2738aclarubicin5.55 μM0.219697451415Miscellaneous811.867922.682416RNA pol III & RNase P/MRP
SGTC_1079idarubicin2.36 μM0.212963636362NIH Clinical Collection533.954821.026610DNA damage response
SGTC_1560lithocholic acid53.1 μM0.2083339903TimTec (Pure natural product library)376.57265.18423
SGTC_1574spiramycin23.7 μM0.26419898TimTec (Pure natural product library)843.052662.049416
SGTC_1974st06944826.9 μM0.26323587TimTec (Natural product derivative library)305.454943.36923
SGTC_257daunorubicin18.5 μM0.19827630323Miscellaneous527.519860.628511anthracycline transcription coupled DNA repair