eugenol

2-methoxy-4-prop-2-enylphenol

Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Anti-Infective Agents;Solvents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2669
Screen concentration 100.0 μM
Source Microsource (Natural product library)
PubChem CID 3314
SMILES COC1=C(C=CC(=C1)CC=C)O
Standardized SMILES COc1cc(CC=C)ccc1O
Molecular weight 164.2011
ALogP 2.58
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.55
% growth inhibition (Hom. pool) 2.47


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3314
Download HIP data (tab-delimited text)  (excel)
Gene:IRA1(YBR140C)|FD-Score:4.09|P-value:2.20E-5|Clearance:1.34||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:RER2(YBR002C)|FD-Score:4.36|P-value:6.62E-6|Clearance:1.34||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:IRA1(YBR140C)|FD-Score:4.09|P-value:2.20E-5|Clearance:1.34||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication Gene:RER2(YBR002C)|FD-Score:4.36|P-value:6.62E-6|Clearance:1.34||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3314
Download HOP data (tab-delimited text)  (excel)
Gene:ARO1(YDR127W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARO3(YDR035W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ATP5(YDR298C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:FLR1(YBR008C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:GCN3(YKR026C)|FD-Score:4.9|P-value:4.67E-7||SGD DESC:Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression Gene:GCN4(YEL009C)|FD-Score:3.73|P-value:9.70E-5||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GDS1(YOR355W)|FD-Score:-3.36|P-value:3.84E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MHR1(YDR296W)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MRPL17(YNL252C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS28(YDR337W)|FD-Score:4.13|P-value:1.84E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OST6(YML019W)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PCI8(YIL071C)|FD-Score:-3.23|P-value:6.20E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PDE2(YOR360C)|FD-Score:-3.38|P-value:3.56E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:RPS6A(YPL090C)|FD-Score:4.34|P-value:7.02E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RSM19(YNR037C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein Gene:SOD1(YJR104C)|FD-Score:3.98|P-value:3.46E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TRE1(YPL176C)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:4.72|P-value:1.21E-6||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:9.64|P-value:2.84E-22||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:7.1|P-value:6.33E-13||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YAR023C(YAR023C_p)|FD-Score:-3.14|P-value:8.48E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family Gene:YDR008C(YDR008C_d)|FD-Score:8.13|P-value:2.19E-16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR379C-A(YDR379C-A)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL068C(YEL068C_p)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER084W(YER084W_p)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER187W(YER187W_p)|FD-Score:3.8|P-value:7.34E-5||SGD DESC:Putative protein of unknown function; induced in respiratory-deficient cells Gene:YGL117W(YGL117W_p)|FD-Score:6.35|P-value:1.08E-10||SGD DESC:Putative protein of unknown function Gene:YJL144W(YJL144W)|FD-Score:4.37|P-value:6.09E-6||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YMR087W(YMR087W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:ARO1(YDR127W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARO3(YDR035W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ATP5(YDR298C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:FLR1(YBR008C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:GCN3(YKR026C)|FD-Score:4.9|P-value:4.67E-7||SGD DESC:Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression Gene:GCN4(YEL009C)|FD-Score:3.73|P-value:9.70E-5||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GDS1(YOR355W)|FD-Score:-3.36|P-value:3.84E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MHR1(YDR296W)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MRPL17(YNL252C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS28(YDR337W)|FD-Score:4.13|P-value:1.84E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OST6(YML019W)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PCI8(YIL071C)|FD-Score:-3.23|P-value:6.20E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PDE2(YOR360C)|FD-Score:-3.38|P-value:3.56E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:RPS6A(YPL090C)|FD-Score:4.34|P-value:7.02E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RSM19(YNR037C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein Gene:SOD1(YJR104C)|FD-Score:3.98|P-value:3.46E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TRE1(YPL176C)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:4.72|P-value:1.21E-6||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:9.64|P-value:2.84E-22||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:7.1|P-value:6.33E-13||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YAR023C(YAR023C_p)|FD-Score:-3.14|P-value:8.48E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family Gene:YDR008C(YDR008C_d)|FD-Score:8.13|P-value:2.19E-16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR379C-A(YDR379C-A)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL068C(YEL068C_p)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER084W(YER084W_p)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER187W(YER187W_p)|FD-Score:3.8|P-value:7.34E-5||SGD DESC:Putative protein of unknown function; induced in respiratory-deficient cells Gene:YGL117W(YGL117W_p)|FD-Score:6.35|P-value:1.08E-10||SGD DESC:Putative protein of unknown function Gene:YJL144W(YJL144W)|FD-Score:4.37|P-value:6.09E-6||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YMR087W(YMR087W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR002C4.366.62E-61.34RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YBR140C4.092.20E-51.34IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YHR197W2.750.002980.03RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YGL113W2.720.003300.11SLD3Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
YFL017W-A2.600.004600.03SMX2Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YJR065C2.580.005000.02ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YHR062C2.560.005240.03RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR308C2.530.005670.11SRB7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YHR188C2.420.007660.04GPI16Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
YPR181C2.390.008520.01SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YBR160W2.370.008870.06CDC28Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress
YBL105C2.310.010300.00PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YCR052W2.310.010400.23RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YFR002W2.080.019000.02NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YLR208W2.050.020100.01SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL211C9.642.84E-22TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YDR008C_d8.132.19E-16YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR354W7.106.33E-13TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YGL117W_p6.351.08E-10YGL117W_pPutative protein of unknown function
YKR026C4.904.67E-7GCN3Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YER090W4.721.21E-6TRP2Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YJL144W4.376.09E-6YJL144WCytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
YPL090C4.347.02E-6RPS6AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
YEL068C_p4.171.49E-5YEL068C_pProtein of unknown function; expressed at both mRNA and protein levels
YDR337W4.131.84E-5MRPS28Mitochondrial ribosomal protein of the small subunit
YJR104C3.983.46E-5SOD1Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
YDR296W3.894.94E-5MHR1Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
YER187W_p3.807.34E-5YER187W_pPutative protein of unknown function; induced in respiratory-deficient cells
YEL009C3.739.70E-5GCN4Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR379C-A3.711.02E-4YDR379C-AProtein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy

GO enrichment analysis for SGTC_2669
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.5420SGTC_2758dehydroepiandrosterone 69.3 μMMiscellaneous58810.0645161
0.5100SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.0645161
0.4980SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.0638298
0.4950SGTC_1801486-1293 102.8 μMChemDiv (Drug-like library)41405360.0704225
0.4790SGTC_14823346-2049 8.5 μMChemDiv (Drug-like library)38268040.0985916
0.4740SGTC_18825615643 20.0 μMMiscellaneous22530750.0985916TRP & mitochondrial translation
0.4541.07E-298SGTC_24885268135 45.7 μMMiscellaneous12703560.0714286
0.4512.52E-293SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.08
0.4512.25E-293SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.0769231TRP & mitochondrial translation
0.4485.54E-290SGTC_14964469-0713 57.4 μMChemDiv (Drug-like library)7466910.107692
0.4466.89E-287SGTC_24785763493 32.3 μMMiscellaneous13655760.140351
0.4451.78E-285SGTC_24865283202 22.4 μMMiscellaneous13777510.0740741
0.4451.12E-284SGTC_1697st025554 27.7 μMTimTec (Natural product derivative library)12695190.0862069
0.4415.22E-279SGTC_1572epiandrosterone 68.9 μMTimTec (Pure natural product library)4413020.047619
0.4407.93E-278SGTC_511013-0126 23.4 μMChemDiv (Drug-like library)16278500.0615385

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1064honokiol6.76 μM0.47572303NIH Clinical Collection266.334324.8822
SGTC_1135dihydrocapsaicin536.71 nM0.392157107982TimTec (Natural product library)307.427764.35423
SGTC_1122capsaicin818.57 nM0.3888891548943TimTec (Natural product library)305.411883.9123
SGTC_2684capsaicin100 μM0.3888891548943Miscellaneous305.411883.9123
SGTC_456gingerol170 μM0.384615442793ICCB bioactive library294.385943.63824
SGTC_3041310-029897 μM0.3777781550234ChemDiv (Drug-like library)366.407084.6225cell wall
SGTC_2551apiole73.87 μM0.35555610659Microsource (Natural product library)222.237162.57304
SGTC_23087584454197.62 μM0.35893577Chembridge (Fragment library)233.059261.71523
SGTC_1700st0308407.93 μM0.3492065499307TimTec (Natural product derivative library)359.333382.92417PDR1
SGTC_1925st05777010.1 μM0.3469395989122TimTec (Natural product derivative library)284.306543.68724TSC3-RPN4
SGTC_1565sinapyl alcohol95.1 μM0.3170735280507TimTec (Pure natural product library)210.226461.41824