butyl paraben

butyl 4-hydroxybenzoate

An antifungal and steroid mimetic.

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2680
Screen concentration 22.2 μM
Source Microsource (Natural product library)
PubChem CID 7184
SMILES CCCCOC(=O)C1=CC=C(C=C1)O
Standardized SMILES CCCCOC(=O)c1ccc(O)cc1
Molecular weight 194.2271
ALogP 2.77
H-bond donor count 1
H-bond acceptor count 3
Response signature amide catabolism

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.22
% growth inhibition (Hom. pool) 10.43


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 7184
Download HIP data (tab-delimited text)  (excel)
Gene:ARP9(YMR033W)|FD-Score:-4.16|P-value:1.56E-5|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DBF4(YDR052C)|FD-Score:3.54|P-value:1.97E-4|Clearance:0.28||SGD DESC:Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress Gene:RLP7(YNL002C)|FD-Score:-3.58|P-value:1.72E-4|Clearance:0||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:RPP1(YHR062C)|FD-Score:3.26|P-value:5.52E-4|Clearance:0.18||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:ARP9(YMR033W)|FD-Score:-4.16|P-value:1.56E-5|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DBF4(YDR052C)|FD-Score:3.54|P-value:1.97E-4|Clearance:0.28||SGD DESC:Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress Gene:RLP7(YNL002C)|FD-Score:-3.58|P-value:1.72E-4|Clearance:0||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:RPP1(YHR062C)|FD-Score:3.26|P-value:5.52E-4|Clearance:0.18||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 7184
Download HOP data (tab-delimited text)  (excel)
Gene:ANP1(YEL036C)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARL1(YBR164C)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:ATG16(YMR159C)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:ATP22(YDR350C)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:COG6(YNL041C)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAL81(YIR023W)|FD-Score:7.3|P-value:1.46E-13||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:EMI1(YDR512C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:GEP3(YOR205C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) Gene:GYP1(YOR070C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HIT1(YJR055W)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:IRS4(YKR019C)|FD-Score:5.13|P-value:1.46E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LCB5(YLR260W)|FD-Score:3.93|P-value:4.30E-5||SGD DESC:Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules Gene:MCT1(YOR221C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MEC3(YLR288C)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MRPL8(YJL063C)|FD-Score:4.36|P-value:6.48E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MZM1(YDR493W)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:RBG1(YAL036C)|FD-Score:5.1|P-value:1.68E-7||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RPL12A(YEL054C)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication Gene:RPL16A(YIL133C)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SAE3(YHR079C-A)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p Gene:SEC66(YBR171W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SER33(YIL074C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:TIP41(YPR040W)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TRP3(YKL211C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YBR285W(YBR285W_p)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER135C(YER135C_d)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YFR057W(YFR057W_p)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Putative protein of unknown function Gene:YKR040C(YKR040C_d)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Gene:YPL247C(YPL247C_p)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Gene:YPL257W(YPL257W_p)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR099C(YPR099C_d)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Gene:YPR197C(YPR197C_d)|FD-Score:3.19|P-value:7.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ANP1(YEL036C)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARL1(YBR164C)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:ATG16(YMR159C)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:ATP22(YDR350C)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:COG6(YNL041C)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAL81(YIR023W)|FD-Score:7.3|P-value:1.46E-13||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:EMI1(YDR512C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:GEP3(YOR205C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) Gene:GYP1(YOR070C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HIT1(YJR055W)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:IRS4(YKR019C)|FD-Score:5.13|P-value:1.46E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LCB5(YLR260W)|FD-Score:3.93|P-value:4.30E-5||SGD DESC:Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules Gene:MCT1(YOR221C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MEC3(YLR288C)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MRPL8(YJL063C)|FD-Score:4.36|P-value:6.48E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MZM1(YDR493W)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:RBG1(YAL036C)|FD-Score:5.1|P-value:1.68E-7||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RPL12A(YEL054C)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication Gene:RPL16A(YIL133C)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SAE3(YHR079C-A)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p Gene:SEC66(YBR171W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SER33(YIL074C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:TIP41(YPR040W)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TRP3(YKL211C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YBR285W(YBR285W_p)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER135C(YER135C_d)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YFR057W(YFR057W_p)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Putative protein of unknown function Gene:YKR040C(YKR040C_d)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Gene:YPL247C(YPL247C_p)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Gene:YPL257W(YPL257W_p)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR099C(YPR099C_d)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Gene:YPR197C(YPR197C_d)|FD-Score:3.19|P-value:7.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR052C3.541.97E-40.28DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YHR062C3.265.52E-40.18RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YEL032W3.080.001030.13MCM3Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YDR429C2.950.001590.03TIF35eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
YNL247W2.920.001730.24YNL247WCysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
YGL044C2.680.003640.07RNA15Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
YOR362C2.610.004490.01PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YER094C2.600.004630.03PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YLR397C2.570.005020.09AFG2ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
YIL115C2.490.006470.03NUP159FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
YKR022C2.450.007110.06NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YBR252W2.400.008290.05DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
YMR061W2.350.009500.02RNA14Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
YPR162C2.330.010000.02ORC4Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YGL103W2.310.010500.01RPL28Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIR023W7.301.46E-13DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YKR019C5.131.46E-7IRS4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
YAL036C5.101.68E-7RBG1Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
YJL063C4.366.48E-6MRPL8Mitochondrial ribosomal protein of the large subunit
YPR099C_d4.201.35E-5YPR099C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
YBR164C3.934.21E-5ARL1Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YLR260W3.934.30E-5LCB5Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YEL054C3.826.58E-5RPL12ARibosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
YBR171W3.571.79E-4SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YOR070C3.571.79E-4GYP1Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YPR040W3.561.84E-4TIP41Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
YER135C_d3.541.99E-4YER135C_dDubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YER130C_p3.502.33E-4YER130C_pProtein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
YPL247C_p3.482.51E-4YPL247C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
YOR205C3.482.55E-4GEP3Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)

GO enrichment analysis for SGTC_2680
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2901.02E-114SGTC_24605552655 174.2 μMMiscellaneous54019890.103448amide catabolism
0.2271.36E-69SGTC_10583448-5425 97.3 μMChemDiv (Drug-like library)72797050.0909091
0.2189.41E-65SGTC_486niguldipine 82.0 μMMiscellaneous12360.189873amide catabolism
0.2178.55E-64SGTC_3371315-0038 354.0 μMChemDiv (Drug-like library)16264370.0540541amide catabolism
0.2101.23E-59SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.0819672amide catabolism
0.1991.13E-53SGTC_10563448-1962 115.0 μMChemDiv (Drug-like library)7155070.265306amide catabolism
0.1977.59E-53SGTC_15998-chlro-1-tetrahydronorharmanone 90.6 μMTimTec (Pure natural product library)41748400.0689655
0.1882.99E-48SGTC_11811222-0449 220.0 μMChemDiv (Drug-like library)6583180.192308
0.1858.73E-47SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.288462amide catabolism
0.1771.19E-42SGTC_413propylparaben 100.0 μMMiscellaneous71750.8amide catabolism
0.1762.66E-42SGTC_6051315-0399 119.0 μMChemDiv (Drug-like library)240204610.056338Golgi
0.1751.12E-41SGTC_5694130-2812 160.0 μMChemDiv (Drug-like library)7435520.115385amide catabolism
0.1721.27E-40SGTC_8230417-1665 178.0 μMChemDiv (Drug-like library)34298560.15942
0.1714.33E-40SGTC_31689103419 49.5 μMChembridge (Drug-like library)166492560.12560S ribosome export
0.1701.72E-39SGTC_7003453-2283 142.0 μMChemDiv (Drug-like library)5656640.145455amide catabolism

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_413propylparaben100 μM0.87175Miscellaneous180.200482.31513amide catabolism
SGTC_2406ethylparaben405.7 μM0.6774198434Miscellaneous166.17391.79213
SGTC_6731082-0474110 μM0.5365853098046ChemDiv (Drug-like library)247.246621.8414RSC complex & mRNA processing
SGTC_1235benzylparaben21.5 μM0.5135147180ChemDiv (Drug-like library)228.243283.02613
SGTC_820054-0107293.76 μM0.3913043104697ChemDiv (Drug-like library)340.412866.11514
SGTC_12220366-00741.18 μM0.380952286520ChemDiv (Drug-like library)245.230741.59204TSC3-RPN4
SGTC_9551216-011033 μM0.3753619719ChemDiv (Drug-like library)290.397245.55813sphingolipid biosynthesis & PDR1
SGTC_1290088-0017176.64 μM0.369565182446ChemDiv (Drug-like library)278.343483.63914
SGTC_13141222-001041.1 μM0.3695653526027ChemDiv (Drug-like library)251.321443.98514
SGTC_980074-0023107.66 μM0.3636363563821ChemDiv (Drug-like library)278.343484.63114Golgi