Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL045W | 21.00 | 1.84E-98 | RIM8 | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family |
YDR466W | 18.10 | 3.63E-73 | PKH3 | Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant |
YIL107C | 17.80 | 4.21E-71 | PFK26 | 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A |
YMR099C | 17.30 | 1.80E-67 | YMR099C | Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS |
YEL022W | 16.70 | 5.07E-63 | GEA2 | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication |
YCR075W-A_p | 14.20 | 2.25E-46 | YCR075W-A_p | Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication |
YEL050C | 14.20 | 8.42E-46 | RML2 | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor |
YJL094C | 12.70 | 3.66E-37 | KHA1 | Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies |
YJR102C | 12.30 | 4.21E-35 | VPS25 | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome |
YNL288W | 12.30 | 5.29E-35 | CAF40 | Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p |
YDL052C | 12.10 | 4.77E-34 | SLC1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes |
YGL117W_p | 11.90 | 4.63E-33 | YGL117W_p | Putative protein of unknown function |
YDR395W | 11.80 | 3.47E-32 | SXM1 | Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 |
YDR101C | 11.70 | 6.51E-32 | ARX1 | Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex |
YBL022C | 11.60 | 2.73E-31 | PIM1 | ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria |