Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJL100W | 9.50 | 1.07E-21 | LSB6 | Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization |
YCL075W | 6.95 | 1.82E-12 | YCL075W | Pseudogene: encodes fragment of Ty Pol protein |
YJL067W_d | 6.84 | 3.99E-12 | YJL067W_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YCL029C | 6.76 | 6.84E-12 | BIK1 | Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 |
YBL054W | 5.99 | 1.04E-9 | TOD6 | PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication |
YPL022W | 5.61 | 1.03E-8 | RAD1 | Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein |
YDR066C_p | 5.59 | 1.15E-8 | RTR2_p | Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication |
YPL015C | 5.54 | 1.48E-8 | HST2 | Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export |
YCL051W | 5.47 | 2.28E-8 | LRE1 | Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication |
YKL128C | 5.19 | 1.04E-7 | PMU1 | Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant |
YFL042C_p | 5.00 | 2.81E-7 | YFL042C_p | Putative protein of unknown function; YFL042C is not an essential gene |
YDR438W | 4.98 | 3.13E-7 | THI74 | Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication |
YDR496C | 4.84 | 6.58E-7 | PUF6 | Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis |
YGR258C | 4.65 | 1.65E-6 | RAD2 | Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein |
YJL057C | 4.64 | 1.77E-6 | IKS1 | Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p |