Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGL099W | 5.66 | 7.69E-9 | 0.66 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YLR033W | 5.00 | 2.91E-7 | 0.29 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YPR112C | 4.70 | 1.28E-6 | 0.01 | MRD1 | Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region |
YAL041W | 4.70 | 1.33E-6 | 0.41 | CDC24 | Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YPL093W | 4.28 | 9.15E-6 | 0.14 | NOG1 | Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins |
YLR430W | 4.14 | 1.74E-5 | 0.27 | SEN1 | Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS |
YDL209C | 3.87 | 5.39E-5 | 0.08 | CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 |
YGL142C | 3.79 | 7.50E-5 | 0.01 | GPI10 | Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog |
YOR210W | 3.79 | 7.67E-5 | 0.30 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YMR290W-A_d | 3.49 | 2.46E-4 | 0.03 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YDR449C | 3.46 | 2.71E-4 | 0.10 | UTP6 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YOR117W | 3.36 | 3.89E-4 | 0.02 | RPT5 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 |
YDR404C | 3.34 | 4.21E-4 | 0.15 | RPB7 | RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation |
YOR224C | 3.19 | 7.22E-4 | 0.02 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YFR051C | 3.17 | 7.66E-4 | 0.08 | RET2 | Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER |