Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YNL041C | 8.42 | 1.83E-17 | COG6 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YBL089W | 6.17 | 3.35E-10 | AVT5 | Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication |
YGL005C | 5.83 | 2.76E-9 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YIL117C | 5.78 | 3.68E-9 | PRM5 | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling |
YDR384C | 5.48 | 2.10E-8 | ATO3 | Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters |
YHL024W | 5.37 | 3.91E-8 | RIM4 | Putative RNA-binding protein required for the expression of early and middle sporulation genes |
YNL289W | 5.37 | 3.92E-8 | PCL1 | Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth |
YKR097W | 5.20 | 9.87E-8 | PCK1 | Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
YBR072W | 4.86 | 5.79E-7 | HSP26 | Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity |
YNL082W | 4.76 | 9.65E-7 | PMS1 | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |
YBR286W | 4.70 | 1.32E-6 | APE3 | Vacuolar aminopeptidase Y, processed to mature form by Prb1p |
YIL124W | 4.66 | 1.56E-6 | AYR1 | NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones |
YBR113W_d | 4.64 | 1.71E-6 | YBR113W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 |
YLR191W | 4.59 | 2.26E-6 | PEX13 | Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p |
YOL071W | 4.43 | 4.70E-6 | EMI5 | Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) |