Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKR019C | 6.31 | 1.41E-10 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YGR208W | 5.86 | 2.35E-9 | SER2 | Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source |
YPL161C | 5.77 | 3.96E-9 | BEM4 | Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length |
YDR293C | 5.11 | 1.65E-7 | SSD1 | Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function |
YOR141C | 5.04 | 2.30E-7 | ARP8 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity |
YMR025W | 4.95 | 3.64E-7 | CSI1 | Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome |
YOR223W | 4.94 | 3.82E-7 | YOR223W | Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 |
YLR124W_d | 4.83 | 6.86E-7 | YLR124W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YBR058C-A | 4.79 | 8.17E-7 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YGL013C | 4.37 | 6.27E-6 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
YPR021C | 4.33 | 7.53E-6 | AGC1 | Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis |
YLR264C-A_p | 4.26 | 1.04E-5 | YLR264C-A_p | Putative protein of unknown function |
YLR030W_p | 4.24 | 1.12E-5 | YLR030W_p | Putative protein of unknown function |
YEL071W | 4.22 | 1.24E-5 | DLD3 | D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm |
YNL082W | 4.21 | 1.25E-5 | PMS1 | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |