Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOL099C_d | 5.49 | 2.04E-8 | YOL099C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes |
YHR143W | 5.11 | 1.63E-7 | DSE2 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP |
YLR267W_p | 4.56 | 2.52E-6 | BOP2_p | Protein of unknown function |
YPL157W | 4.52 | 3.06E-6 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
YER134C | 4.39 | 5.64E-6 | YER134C | Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene |
YPL141C | 4.27 | 9.65E-6 | FRK1 | Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication |
YGL190C | 3.98 | 3.39E-5 | CDC55 | Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion |
YCL012C | 3.93 | 4.30E-5 | YCL012C | Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene |
YDR216W | 3.92 | 4.44E-5 | ADR1 | Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization |
YGR058W | 3.75 | 8.98E-5 | PEF1 | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
YBR222C | 3.68 | 1.14E-4 | PCS60 | Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase |
YNL081C | 3.59 | 1.66E-4 | SWS2 | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
YNL274C | 3.50 | 2.31E-4 | GOR1 | Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress |
YFR017C | 3.48 | 2.52E-4 | IGD1 | Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication |
YOL159C | 3.43 | 3.06E-4 | YOL159C | Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA |