salbutamol FDA approved compound

4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; sulfuric acid

β2-adrenoceptor agonist

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2723
Screen concentration 83.6 μM
Source NIH Clinical Collection
PubChem CID 9884233
SMILES CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.OS(=O)(=O)O
Standardized SMILES CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
Molecular weight 337.3892
ALogP 0.33
H-bond donor count 6
H-bond acceptor count 8
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.41
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 9884233
Download HIP data (tab-delimited text)  (excel)
Gene:RIB5(YBR256C)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.37||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:UFE1(YOR075W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.37||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:YMR290W-A(YMR290W-A_d)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:RIB5(YBR256C)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.37||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:UFE1(YOR075W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.37||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:YMR290W-A(YMR290W-A_d)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 9884233
Download HOP data (tab-delimited text)  (excel)
Gene:AAD4(YDL243C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ABF2(YMR072W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:AHA1(YDR214W)|FD-Score:4.84|P-value:6.64E-7||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:APP1(YNL094W)|FD-Score:3.19|P-value:7.04E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:BNA4(YBL098W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease Gene:CPR5(YDR304C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER Gene:DBF2(YGR092W)|FD-Score:-3.2|P-value:6.80E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:EGD2(YHR193C)|FD-Score:4.74|P-value:1.09E-6||SGD DESC:Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes Gene:FMP27(YLR454W_p)|FD-Score:4.28|P-value:9.47E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HCM1(YCR065W)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role Gene:HFM1(YGL251C)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity Gene:MSA2(YKR077W)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation Gene:NDE1(YMR145C)|FD-Score:4.32|P-value:7.65E-6||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:OYE2(YHR179W)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:RHO4(YKR055W)|FD-Score:5.14|P-value:1.36E-7||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity Gene:THP2(YHR167W)|FD-Score:4.48|P-value:3.66E-6||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UBP7(YIL156W)|FD-Score:-3.99|P-value:3.32E-5||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:YER184C(YER184C_p)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YHP1(YDR451C)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YKR011C(YKR011C_p)|FD-Score:5.37|P-value:3.85E-8||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress Gene:YPR147C(YPR147C_p)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YRM1(YOR172W)|FD-Score:-3.13|P-value:8.79E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:AAD4(YDL243C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ABF2(YMR072W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:AHA1(YDR214W)|FD-Score:4.84|P-value:6.64E-7||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:APP1(YNL094W)|FD-Score:3.19|P-value:7.04E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:BNA4(YBL098W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease Gene:CPR5(YDR304C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER Gene:DBF2(YGR092W)|FD-Score:-3.2|P-value:6.80E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:EGD2(YHR193C)|FD-Score:4.74|P-value:1.09E-6||SGD DESC:Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes Gene:FMP27(YLR454W_p)|FD-Score:4.28|P-value:9.47E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HCM1(YCR065W)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role Gene:HFM1(YGL251C)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity Gene:MSA2(YKR077W)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation Gene:NDE1(YMR145C)|FD-Score:4.32|P-value:7.65E-6||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:OYE2(YHR179W)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:RHO4(YKR055W)|FD-Score:5.14|P-value:1.36E-7||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity Gene:THP2(YHR167W)|FD-Score:4.48|P-value:3.66E-6||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UBP7(YIL156W)|FD-Score:-3.99|P-value:3.32E-5||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:YER184C(YER184C_p)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YHP1(YDR451C)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YKR011C(YKR011C_p)|FD-Score:5.37|P-value:3.85E-8||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress Gene:YPR147C(YPR147C_p)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YRM1(YOR172W)|FD-Score:-3.13|P-value:8.79E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR075W3.581.71E-40.37UFE1t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
YBR256C3.265.64E-40.37RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YNR017W2.890.001930.09TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YFR042W2.800.002575.55E-5KEG1Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
YOR256C2.800.002570.02TRE2Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
YAL034C-B_d2.780.002740.08YAL034C-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL141W2.700.003490.01SDH3Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
YIL104C2.690.003610.10SHQ1Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
YLR310C2.590.004790.14CDC25Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
YGL074C_d2.460.007040.01YGL074C_dDubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YOR340C2.440.007330.02RPA43RNA polymerase I subunit A43
YBR121C2.420.007680.00GRS1Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
YKL196C2.420.007700.02YKT6Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
YPL233W2.400.008163.47E-4NSL1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YLR314C2.400.008170.00CDC3Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKR011C_p5.373.85E-8YKR011C_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
YKR055W5.141.36E-7RHO4Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YDR214W4.846.64E-7AHA1Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
YHR193C4.741.09E-6EGD2Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YHR167W4.483.66E-6THP2Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YMR145C4.327.65E-6NDE1Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YLR454W_p4.289.47E-6FMP27_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR147C_p4.171.53E-5YPR147C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YCR065W4.052.51E-5HCM1Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YBL098W3.661.25E-4BNA4Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
YKR077W3.452.82E-4MSA2Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
YDL243C3.442.91E-4AAD4Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
YMR072W3.433.00E-4ABF2Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YER184C_p3.403.37E-4YER184C_pPutative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YDR451C3.304.86E-4YHP1Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2723
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0863.72E-11SGTC_587k089-0003 57.0 μMChemDiv (Drug-like library)96596960.0842105
0.0759.25E-9SGTC_20765212012 200.0 μMChembridge (Fragment library)6048020.0483871
0.0741.14E-8SGTC_23945221648 200.0 μMMiscellaneous7885860.05
0.0714.50E-8SGTC_1852st056254 31.4 μMTimTec (Natural product derivative library)4425830.0769231
0.0648.09E-7SGTC_1949st076024 69.1 μMTimTec (Natural product derivative library)29219300.0684932
0.0631.27E-6SGTC_1578josamycin 24.2 μMTimTec (Pure natural product library)52821650.047619
0.0631.49E-6SGTC_14384092-1045 4.0 μMChemDiv (Drug-like library)13513420.0172414
0.0595.30E-6SGTC_31439086658 49.5 μMChembridge (Drug-like library)252366260.0615385
0.0589.94E-6SGTC_615k087-0205 167.0 μMChemDiv (Drug-like library)96427730.0957447
0.0561.96E-5SGTC_1618st003135 44.5 μMTimTec (Natural product derivative library)12706150.101266
0.0562.00E-5SGTC_8333852-0053 558.0 μMChemDiv (Drug-like library)31236810.0897436
0.0552.81E-5SGTC_1579chlormadinone acetate 49.4 μMMiscellaneous451142580.0375
0.0526.45E-5SGTC_9801473-0395 201.0 μMChemDiv (Drug-like library)7688760.0769231
0.0527.15E-5SGTC_8540422-0053 192.0 μMChemDiv (Drug-like library)35967280.0615385PDR1
0.0518.94E-5SGTC_14494112-4002 201.0 μMChemDiv (Drug-like library)20595390.0694444RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2181631624054.26 μM0.35714312779990Chembridge (Fragment library)200.233182.50122
SGTC_13311472-004976.2 μM0.26315824051409ChemDiv (Drug-like library)286.325723.57824
SGTC_23087584454197.62 μM0.255319893577Chembridge (Fragment library)233.059261.71523
SGTC_9821491-051827.5 μM0.2542373091256ChemDiv (Drug-like library)416.265653.336211
SGTC_470149-013524.25 μM0.2448985239155ChemDiv (Drug-like library)328.445225.87933TSC3-RPN4
SGTC_23217390090138.78 μM0.240741649046Chembridge (Fragment library)214.263062.85423
SGTC_275trichlorophene5.69 μM0.2391362616Miscellaneous409.69037.04633mitochondrial stress
SGTC_2764methyldopa94.69 μM0.23529438853Miscellaneous211.21452-1.77845
SGTC_23699071472200 μM0.23404317296037Chembridge (Fragment library)219.774622.90722
SGTC_4982,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)150 μM0.2307692374ICCB bioactive library222.323284.14622Golgi