Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR202W | 16.90 | 5.03E-64 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
YGL054C | 9.66 | 2.17E-22 | ERV14 | COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication |
YBL049W | 5.95 | 1.32E-9 | MOH1 | Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase |
YER031C | 5.04 | 2.34E-7 | YPT31 | Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication |
YGR248W | 4.88 | 5.35E-7 | SOL4 | 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication |
YMR029C | 4.36 | 6.38E-6 | FAR8 | Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p |
YIL055C_p | 4.34 | 7.28E-6 | YIL055C_p | Putative protein of unknown function |
YGL071W | 4.31 | 8.34E-6 | AFT1 | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YKL190W | 4.30 | 8.46E-6 | CNB1 | Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress |
YHR009C_p | 4.26 | 1.03E-5 | TDA3_p | Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 |
YJL100W | 4.18 | 1.48E-5 | LSB6 | Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization |
YGR127W_p | 4.14 | 1.73E-5 | YGR127W_p | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
YLL020C_d | 4.10 | 2.04E-5 | YLL020C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 |
YJR116W_p | 4.05 | 2.59E-5 | TDA4_p | Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele |
YDL096C_d | 3.98 | 3.39E-5 | OPI6_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential |