chlorpromazine FDA approved compound

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine

A thorazine and dopamine antagonist.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Antiemetics;Antipsychotic Agents;Dopamine Antagonists



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2728
Screen concentration 9.2 μM
Source Miscellaneous
PubChem CID 2726
SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Standardized SMILES CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
Molecular weight 318.8642
ALogP 4.74
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.39
% growth inhibition (Hom. pool) 3.82


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2726
Download HIP data (tab-delimited text)  (excel)
Gene:CCT8(YJL008C)|FD-Score:3.38|P-value:3.58E-4|Clearance:0.04||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:DIS3(YOL021C)|FD-Score:3.44|P-value:2.90E-4|Clearance:0.06||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:GPI18(YBR004C)|FD-Score:3.88|P-value:5.18E-5|Clearance:0.44||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:NEO1(YIL048W)|FD-Score:5.49|P-value:1.98E-8|Clearance:1.25||SGD DESC:Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus Gene:SUP45(YBR143C)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.36||SGD DESC:Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p Gene:TAF7(YMR227C)|FD-Score:3.35|P-value:4.08E-4|Clearance:0.27||SGD DESC:TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation Gene:CCT8(YJL008C)|FD-Score:3.38|P-value:3.58E-4|Clearance:0.04||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:DIS3(YOL021C)|FD-Score:3.44|P-value:2.90E-4|Clearance:0.06||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:GPI18(YBR004C)|FD-Score:3.88|P-value:5.18E-5|Clearance:0.44||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:NEO1(YIL048W)|FD-Score:5.49|P-value:1.98E-8|Clearance:1.25||SGD DESC:Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus Gene:SUP45(YBR143C)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.36||SGD DESC:Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p Gene:TAF7(YMR227C)|FD-Score:3.35|P-value:4.08E-4|Clearance:0.27||SGD DESC:TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2726
Download HOP data (tab-delimited text)  (excel)
Gene:COX17(YLL009C)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:ERV41(YML067C)|FD-Score:3.95|P-value:3.90E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:HOS1(YPR068C)|FD-Score:-4.07|P-value:2.38E-5||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:HUR1(YGL168W)|FD-Score:3.25|P-value:5.72E-4||SGD DESC:Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene Gene:LST7(YGR057C)|FD-Score:3.8|P-value:7.15E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MRPL51(YPR100W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PUS1(YPL212C)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA Gene:RAM1(YDL090C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:SCO1(YBR037C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:TIF1(YKR059W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication Gene:VMA4(YOR332W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress Gene:YIR024C(YIR024C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect Gene:YLR030W(YLR030W_p)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:Putative protein of unknown function Gene:YPS3(YLR121C)|FD-Score:4.36|P-value:6.50E-6||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:COX17(YLL009C)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:ERV41(YML067C)|FD-Score:3.95|P-value:3.90E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:HOS1(YPR068C)|FD-Score:-4.07|P-value:2.38E-5||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:HUR1(YGL168W)|FD-Score:3.25|P-value:5.72E-4||SGD DESC:Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene Gene:LST7(YGR057C)|FD-Score:3.8|P-value:7.15E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MRPL51(YPR100W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PUS1(YPL212C)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA Gene:RAM1(YDL090C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:SCO1(YBR037C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:TIF1(YKR059W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication Gene:VMA4(YOR332W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress Gene:YIR024C(YIR024C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect Gene:YLR030W(YLR030W_p)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:Putative protein of unknown function Gene:YPS3(YLR121C)|FD-Score:4.36|P-value:6.50E-6||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YIL048W5.491.98E-81.25NEO1Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YBR143C4.241.12E-50.36SUP45Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
YBR004C3.885.18E-50.44GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YOL021C3.442.90E-40.06DIS3Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
YJL008C3.383.58E-40.04CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YMR227C3.354.08E-40.27TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YDL031W3.080.001050.08DBP10Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YMR061W2.990.001370.04RNA14Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
YNL178W2.960.001540.07RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YNL002C2.890.001950.13RLP7Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YDR180W2.750.002940.00SCC2Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
YGL207W2.750.002970.26SPT16Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
YLR197W2.490.006410.14NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YCL054W2.350.009300.06SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDR045C2.290.011000.01RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR121C4.366.50E-6YPS3Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YML067C3.953.90E-5ERV41Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
YGR057C3.807.15E-5LST7Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YBR037C3.691.11E-4SCO1Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication
YIR024C3.651.29E-4YIR024CProtein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
YDL090C3.413.24E-4RAM1Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YPR100W3.334.34E-4MRPL51Mitochondrial ribosomal protein of the large subunit
YKR059W3.324.46E-4TIF1Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
YGL168W3.255.72E-4HUR1Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
YOR332W3.129.15E-4VMA4Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
YNL059C3.080.00102ARP5Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YNL230C3.050.00113ELA1Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex
YDR418W3.040.00117RPL12BRibosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
YKL023W_p3.010.00131YKL023W_pPutative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBL071C-B_p3.000.00134YBL071C-B_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

GO enrichment analysis for SGTC_2728
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2704.95E-99SGTC_1721112-0046 2.6 μMChemDiv (Drug-like library)28021350.171875NEO1
0.2663.65E-96SGTC_1680diphenhydramine 100.0 μMNIH Clinical Collection89800.235294NEO1
0.2636.28E-94SGTC_1665st014639 11.4 μMTimTec (Natural product derivative library)9811330.154762NEO1
0.2621.67E-93SGTC_270tamoxifen 5.5 μMMiscellaneous53760.196721NEO1
0.2562.85E-89SGTC_8880916-0002 7.0 μMChemDiv (Drug-like library)28021380.171875NEO1
0.2561.24E-88SGTC_2658polymyxin b sulfate 77.0 μMMicrosource (Natural product library)57021050.0666667NEO1
0.2411.61E-78SGTC_9403232-1287 54.8 μMChemDiv (Drug-like library)15854930.189189NEO1
0.2398.11E-78SGTC_5352293-4129 48.2 μMChemDiv (Drug-like library)3961180.3125NEO1
0.2301.14E-71SGTC_9001112-0045 141.0 μMChemDiv (Drug-like library)562110.109375NEO1
0.2276.87E-70SGTC_1991st073000 8.9 μMTimTec (Natural product derivative library)43019690.0909091NEO1
0.2228.31E-67SGTC_1797st048695 56.8 μMTimTec (Natural product derivative library)5922620.0933333NEO1
0.2221.05E-66SGTC_1781st038725 66.3 μMTimTec (Natural product derivative library)42702750.121212NEO1
0.2144.24E-62SGTC_11303454-2858 15.9 μMChemDiv (Drug-like library)7156280.169231NEO1
0.1951.87E-51SGTC_3014119-0100 24.5 μMChemDiv (Drug-like library)28010.617021NEO1
0.1942.13E-51SGTC_232clozapine 119.0 μMMiscellaneous28180.19697NEO1

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1065prochlorperazine maleate2.48 μM0.6326536436057NIH Clinical Collection490.01482-1.33428
SGTC_3014119-010024.5 μM0.6170212801ChemDiv (Drug-like library)314.852325.05202NEO1
SGTC_2730imipramine71.33 μM0.4888893696Miscellaneous280.407264.38702
SGTC_221trifluoperazine10.3 μM0.4310345566Miscellaneous407.495574.97507NEO1-PIK1
SGTC_264promethazine12.5 mM0.4255326014Miscellaneous320.880044.77213DNA intercalators
SGTC_1093fluphenazine7.97 μM0.406786602611NIH Clinical Collection473.982494.81728
SGTC_2729fluphenazine10.66 μM0.406783372Miscellaneous437.521554.43518
SGTC_430570-010572.5 μM0.3965521114046ChemDiv (Drug-like library)380.890484.73913ERG2
SGTC_2773thioridazine9.09 μM0.3650795452Miscellaneous370.574545.56304
SGTC_1062mesoridazine14.2 μM0.3538464078Miscellaneous386.573944.45105
SGTC_2742clothiapine36.27 μM0.31666716351Miscellaneous343.873623.99103NEO1