Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJL111W | 4.18 | 1.45E-5 | 0.42 | CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
YMR168C | 3.76 | 8.46E-5 | 0.21 | CEP3 | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
YIR008C | 3.55 | 1.89E-4 | 0.29 | PRI1 | Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair |
YJL054W | 3.27 | 5.42E-4 | 0.05 | TIM54 | Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane |
YDR053W_d | 3.22 | 6.38E-4 | 0.09 | YDR053W_d | Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex |
YML085C | 3.13 | 8.71E-4 | 0.05 | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
YJL014W | 3.08 | 0.00103 | 0.09 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YDR180W | 2.99 | 0.00140 | 0.04 | SCC2 | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin |
YGL044C | 2.95 | 0.00158 | 0.12 | RNA15 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping |
YLL036C | 2.84 | 0.00229 | 0.08 | PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain |
YLL003W | 2.76 | 0.00292 | 0.19 | SFI1 | Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C |
YBR140C | 2.57 | 0.00507 | 0.06 | IRA1 | GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication |
YKL013C | 2.51 | 0.00596 | 0.03 | ARC19 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YHR062C | 2.48 | 0.00653 | 0.07 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YOL120C | 2.42 | 0.00785 | 0.11 | RPL18A | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication |