Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPL161C | 6.23 | 2.32E-10 | BEM4 | Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length |
YMR216C | 4.74 | 1.05E-6 | SKY1 | SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 |
YIL138C | 4.52 | 3.04E-6 | TPM2 | Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication |
YJL047C | 4.38 | 5.90E-6 | RTT101 | Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p |
YCL016C | 4.26 | 1.03E-5 | DCC1 | Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance |
YNL250W | 3.76 | 8.35E-5 | RAD50 | Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress |
YBL104C | 3.70 | 1.09E-4 | SEA4 | Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites |
YHL047C | 3.68 | 1.16E-4 | ARN2 | Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C |
YBR281C | 3.40 | 3.34E-4 | DUG2 | Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) |
YMR275C | 3.36 | 3.92E-4 | BUL1 | Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication |
YNL248C | 3.29 | 5.09E-4 | RPA49 | RNA polymerase I subunit A49 |
YPL157W | 3.21 | 6.61E-4 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
YMR267W | 3.17 | 7.68E-4 | PPA2 | Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate |
YDL067C | 3.15 | 8.26E-4 | COX9 | Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
YNL057W_d | 3.12 | 9.02E-4 | YNL057W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |