diazoxide FDA approved compound

7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide

A potassium channel activatior.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Antihypertensive Agents;Vasodilator Agents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2748
Screen concentration 86.7 μM
Source Miscellaneous
PubChem CID 3019
SMILES CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
Standardized SMILES CC1=NS(=O)(=O)c2cc(Cl)ccc2N1
Molecular weight 230.6714
ALogP 0.55
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.2
% growth inhibition (Hom. pool) 3.73


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3019
Download HIP data (tab-delimited text)  (excel)
Gene:CCT4(YDL143W)|FD-Score:4.11|P-value:1.98E-5|Clearance:0.71||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NFS1(YCL017C)|FD-Score:5.61|P-value:9.86E-9|Clearance:1.51||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PRP24(YMR268C)|FD-Score:3.39|P-value:3.43E-4|Clearance:0.28||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:RRP46(YGR095C)|FD-Score:3.11|P-value:9.29E-4|Clearance:0.41||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:SPC42(YKL042W)|FD-Score:-3.51|P-value:2.21E-4|Clearance:0||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:SPT16(YGL207W)|FD-Score:-3.14|P-value:8.39E-4|Clearance:0||SGD DESC:Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome Gene:CCT4(YDL143W)|FD-Score:4.11|P-value:1.98E-5|Clearance:0.71||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NFS1(YCL017C)|FD-Score:5.61|P-value:9.86E-9|Clearance:1.51||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PRP24(YMR268C)|FD-Score:3.39|P-value:3.43E-4|Clearance:0.28||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:RRP46(YGR095C)|FD-Score:3.11|P-value:9.29E-4|Clearance:0.41||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:SPC42(YKL042W)|FD-Score:-3.51|P-value:2.21E-4|Clearance:0||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:SPT16(YGL207W)|FD-Score:-3.14|P-value:8.39E-4|Clearance:0||SGD DESC:Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3019
Download HOP data (tab-delimited text)  (excel)
Gene:ATP11(YNL315C)|FD-Score:4.36|P-value:6.49E-6||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:AUS1(YOR011W)|FD-Score:3.13|P-value:8.68E-4||SGD DESC:Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen Gene:BUD26(YDR241W_d)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC55(YGL190C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion Gene:COX12(YLR038C)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:COX18(YGR062C)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:EXO5(YBR163W)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:GCV3(YAL044C)|FD-Score:3.92|P-value:4.44E-5||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:HSL7(YBR133C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:ILV6(YCL009C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria Gene:ISM1(YPL040C)|FD-Score:4.77|P-value:9.35E-7||SGD DESC:Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth Gene:MBP1(YDL056W)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MF(ALPHA)1(YPL187W)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MIG2(YGL209W)|FD-Score:3.73|P-value:9.66E-5||SGD DESC:Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication Gene:MRP17(YKL003C)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MSC7(YHR039C)|FD-Score:4.98|P-value:3.22E-7||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:NSG1(YHR133C)|FD-Score:4.51|P-value:3.20E-6||SGD DESC:Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress Gene:POP2(YNR052C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PPA2(YMR267W)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:RPL7A(YGL076C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:SEC22(YLR268W)|FD-Score:4.63|P-value:1.85E-6||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:UPC2(YDR213W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YDR157W(YDR157W_d)|FD-Score:3.23|P-value:6.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER077C(YER077C_p)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YML009W-B(YML009W-B_d)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YNR061C(YNR061C_p)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:ATP11(YNL315C)|FD-Score:4.36|P-value:6.49E-6||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:AUS1(YOR011W)|FD-Score:3.13|P-value:8.68E-4||SGD DESC:Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen Gene:BUD26(YDR241W_d)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC55(YGL190C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion Gene:COX12(YLR038C)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:COX18(YGR062C)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:EXO5(YBR163W)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:GCV3(YAL044C)|FD-Score:3.92|P-value:4.44E-5||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:HSL7(YBR133C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:ILV6(YCL009C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria Gene:ISM1(YPL040C)|FD-Score:4.77|P-value:9.35E-7||SGD DESC:Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth Gene:MBP1(YDL056W)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MF(ALPHA)1(YPL187W)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MIG2(YGL209W)|FD-Score:3.73|P-value:9.66E-5||SGD DESC:Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication Gene:MRP17(YKL003C)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MSC7(YHR039C)|FD-Score:4.98|P-value:3.22E-7||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:NSG1(YHR133C)|FD-Score:4.51|P-value:3.20E-6||SGD DESC:Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress Gene:POP2(YNR052C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PPA2(YMR267W)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:RPL7A(YGL076C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:SEC22(YLR268W)|FD-Score:4.63|P-value:1.85E-6||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:UPC2(YDR213W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YDR157W(YDR157W_d)|FD-Score:3.23|P-value:6.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER077C(YER077C_p)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YML009W-B(YML009W-B_d)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YNR061C(YNR061C_p)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCL017C5.619.86E-91.51NFS1Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YDL143W4.111.98E-50.71CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YMR268C3.393.43E-40.28PRP24Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YGR095C3.119.29E-40.41RRP46Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
YPL146C2.700.003470.03NOP53Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YAL041W2.670.003780.02CDC24Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress
YOR206W2.660.003950.02NOC2Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YIL078W2.630.004260.09THS1Threonyl-tRNA synthetase, essential cytoplasmic protein
YNL178W2.540.005540.17RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YFL039C2.370.009010.11ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YDL152W_d2.260.012000.03YDL152W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YBL092W2.230.012900.08RPL32Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
YEL002C2.150.015700.01WBP1Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
YHR005C-A2.140.016000.09TIM10Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YBR247C2.050.020100.02ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YHR039C4.983.22E-7MSC7Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YPL040C4.779.35E-7ISM1Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YLR268W4.631.85E-6SEC22R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YHR133C4.513.20E-6NSG1Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress
YNL315C4.366.49E-6ATP11Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YMR267W4.221.23E-5PPA2Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YPL187W4.102.05E-5MF(ALPHA)1Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YAL044C3.924.44E-5GCV3H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
YGL209W3.739.66E-5MIG2Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication
YCL009C3.661.24E-4ILV6Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
YNR052C3.661.28E-4POP2RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
YNR061C_p3.631.39E-4YNR061C_pProtein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
YGR062C3.581.73E-4COX18Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
YBR163W3.542.01E-4EXO5Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
YLR038C3.512.22E-4COX12Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV

GO enrichment analysis for SGTC_2748
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0856.02E-11SGTC_1180083-0097 135.3 μMChemDiv (Drug-like library)52073560.0886076translation
0.0832.13E-10SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.0666667mitochondrial stress
0.0815.70E-10SGTC_31449087057 49.5 μMChembridge (Drug-like library)172496180.111111
0.0773.18E-9SGTC_7700389-1121 67.2 μMChemDiv (Drug-like library)67531080.0875RPP1 & pyrimidine depletion
0.0773.44E-9SGTC_1692fluoroquinolonic acid 71.0 μMTimTec (Natural product derivative library)4831800.09375
0.0758.97E-9SGTC_1695st026914 34.5 μMTimTec (Natural product derivative library)32891910.142857
0.0759.29E-9SGTC_11453546-0597 10.2 μMChemDiv (Drug-like library)8753340.111111mitochondrial processes
0.0759.80E-9SGTC_8800833-0487 87.2 μMChemDiv (Drug-like library)760750.0784314mitochondrial processes
0.0741.08E-8SGTC_2624nerol 100.0 μMMicrosource (Natural product library)6375660.0204082
0.0713.91E-8SGTC_1667st014849 34.6 μMTimTec (Natural product derivative library)53484600.0641026Golgi
0.0714.01E-8SGTC_20455106652 78.0 μMChembridge (Fragment library)6733490.0677966
0.0681.60E-7SGTC_27847567673 72.7 μMChembridge (Drug-like library)34712470.0793651iron homeostasis
0.0648.73E-7SGTC_31509097574 49.5 μMChembridge (Drug-like library)172174760.0857143
0.0612.32E-6SGTC_2692st077426 47.7 μMTimTec (Natural product derivative library)252385710.102564
0.0612.59E-6SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.145833TRP & mitochondrial translation

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13913442-0225151 μM0.2826095227075ChemDiv (Drug-like library)259.323522.97813
SGTC_2405ticlatone3.52 μM0.256258Miscellaneous185.630762.03912
SGTC_232clozapine119 μM0.2456142818Miscellaneous326.823263.47614NEO1
SGTC_443clozapine122 μM0.2456142818Miscellaneous326.823263.47614NEO1-PIK1
SGTC_2001402350257.66 μM0.244444108941Chembridge (Fragment library)195.602441.5402mitochondrial processes
SGTC_23916285546200 μM0.235294846083Chembridge (Fragment library)208.644262.1612
SGTC_23369001819198.65 μM0.2291672989602Chembridge (Fragment library)209.629021.88902heme biosynthesis & mitochondrial translocase
SGTC_1743553-038974.3 μM0.226415738071ChemDiv (Drug-like library)287.78563.25414
SGTC_12580671-004357.1 μM0.2264154298767ChemDiv (Drug-like library)296.772522.72124
SGTC_1036k216-021533.5 μM0.22449622330ChemDiv (Drug-like library)266.681883.90803mitochondrial response to ROS
SGTC_2731amoxapine43.43 μM0.2241382170Miscellaneous313.781442.89713