Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR028W | 5.29 | 6.05E-8 | 0.63 | TAP42 | Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits |
YFL029C | 4.66 | 1.58E-6 | 0.08 | CAK1 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
YDR280W | 4.58 | 2.32E-6 | 0.00 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YDL014W | 4.58 | 2.37E-6 | 0.18 | NOP1 | Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin |
YDR429C | 4.40 | 5.46E-6 | 0.21 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YFR029W | 4.19 | 1.42E-5 | 0.00 | PTR3 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YGL172W | 4.18 | 1.45E-5 | 0.15 | NUP49 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) |
YFR050C | 4.03 | 2.81E-5 | 0.44 | PRE4 | Beta 7 subunit of the 20S proteasome |
YNL103W | 3.59 | 1.65E-4 | 0.16 | MET4 | Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p |
YML085C | 3.43 | 3.04E-4 | 0.06 | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
YJR006W | 3.37 | 3.81E-4 | 0.12 | POL31 | Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair |
YKL060C | 3.25 | 5.81E-4 | 0.02 | FBA1 | Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress |
YER112W | 3.23 | 6.16E-4 | 0.27 | LSM4 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress |
YOR004W | 2.97 | 0.00151 | 0.11 | UTP23 | Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein |
YLR314C | 2.86 | 0.00212 | 0.04 | CDC3 | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells |