| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YNL107W | 6.22 | 2.54E-10 | YAF9 | Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain |
| YDR536W | 5.84 | 2.57E-9 | STL1 | Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
| YOR309C_d | 5.67 | 7.10E-9 | YOR309C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 |
| YNR029C_p | 5.60 | 1.09E-8 | YNR029C_p | Putative protein of unknown function, deletion confers reduced fitness in saline |
| YDR241W_d | 5.53 | 1.64E-8 | BUD26_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
| YCR026C | 5.16 | 1.25E-7 | NPP1 | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication |
| YGR163W | 4.63 | 1.85E-6 | GTR2 | Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD |
| YFR048W | 4.60 | 2.14E-6 | RMD8 | Cytosolic protein required for sporulation |
| YOR121C_d | 4.48 | 3.67E-6 | YOR121C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W |
| YDL130W | 4.47 | 3.88E-6 | RPP1B | Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component |
| YMR018W_p | 4.24 | 1.14E-5 | YMR018W_p | Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene |
| YGL105W | 4.20 | 1.31E-5 | ARC1 | Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress |
| YOR354C | 4.11 | 1.97E-5 | MSC6 | Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YFR034C | 4.07 | 2.38E-5 | PHO4 | Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability |
| YLR309C | 4.05 | 2.60E-5 | IMH1 | Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi |
