Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL204C | 5.73 | 5.08E-9 | SPS18 | Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation |
YGR290W_d | 5.26 | 7.23E-8 | YGR290W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) |
YDR444W_p | 5.25 | 7.45E-8 | YDR444W_p | Putative hydrolase acting on ester bonds |
YEL016C | 5.03 | 2.46E-7 | NPP2 | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication |
YPR002W | 5.01 | 2.71E-7 | PDH1 | Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate |
YML026C | 4.78 | 8.95E-7 | RPS18B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YMR032W | 4.52 | 3.14E-6 | HOF1 | Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p |
YPL157W | 4.48 | 3.78E-6 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
YMR151W_d | 4.43 | 4.74E-6 | YIM2_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 |
YAL020C | 4.34 | 7.02E-6 | ATS1 | Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle |
YAL018C_p | 4.26 | 1.01E-5 | YAL018C_p | Putative protein of unknown function |
YBR006W | 4.19 | 1.40E-5 | UGA2 | Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm |
YJL058C | 4.16 | 1.59E-5 | BIT61 | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication |
YGR273C_p | 4.11 | 1.98E-5 | YGR273C_p | Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene |
YJR019C | 3.98 | 3.42E-5 | TES1 | Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids |