sulfasalazine FDA approved compound

6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid

An antioxidant and salicylic acid derivative.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Anti-Infective Agents;Anti-Inflammatory Agents, Non-Steroidal;Antirheumatic Agents;Gastrointestinal Agents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2768
Screen concentration 50.2 μM
Source Miscellaneous
PubChem CID 5384001
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O
Standardized SMILES OC(=O)c1cc(ccc1O)N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3
Molecular weight 398.3926
ALogP 2.01
H-bond donor count 3
H-bond acceptor count 9
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.2
% growth inhibition (Hom. pool) -2.75


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5384001
Download HIP data (tab-delimited text)  (excel)
Gene:HIP1(YGR191W)|FD-Score:3.44|P-value:2.95E-4|Clearance:0.05||SGD DESC:High-affinity histidine permease, also involved in the transport of manganese ions Gene:HSH49(YOR319W)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.12||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:LSM2(YBL026W)|FD-Score:3.22|P-value:6.38E-4|Clearance:0.17||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:NAT2(YGR147C)|FD-Score:-3.29|P-value:5.06E-4|Clearance:0||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOG2(YNR053C)|FD-Score:4|P-value:3.12E-5|Clearance:0.03||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:PMI40(YER003C)|FD-Score:6.18|P-value:3.23E-10|Clearance:0.8||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:POL31(YJR006W)|FD-Score:4.24|P-value:1.10E-5|Clearance:0.22||SGD DESC:Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair Gene:PRP28(YDR243C)|FD-Score:3.49|P-value:2.45E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:PRP46(YPL151C)|FD-Score:3.79|P-value:7.40E-5|Clearance:0.04||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:RFC3(YNL290W)|FD-Score:3.24|P-value:5.96E-4|Clearance:0.02||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPB10(YOR210W)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.07||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPB3(YIL021W)|FD-Score:6|P-value:9.82E-10|Clearance:0.8||SGD DESC:RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit Gene:RPB7(YDR404C)|FD-Score:3.69|P-value:1.12E-4|Clearance:0.03||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RRP9(YPR137W)|FD-Score:5.68|P-value:6.75E-9|Clearance:0.8||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RSC9(YML127W)|FD-Score:3.66|P-value:1.27E-4|Clearance:0.17||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:RSE1(YML049C)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport Gene:SCC4(YER147C)|FD-Score:-4.5|P-value:3.40E-6|Clearance:0||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SDS22(YKL193C)|FD-Score:3.97|P-value:3.59E-5|Clearance:0.03||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SEC16(YPL085W)|FD-Score:-4.26|P-value:1.02E-5|Clearance:0||SGD DESC:COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p Gene:SEC31(YDL195W)|FD-Score:3.38|P-value:3.58E-4|Clearance:0.02||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SPB4(YFL002C)|FD-Score:3.84|P-value:6.27E-5|Clearance:0.04||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:SSL1(YLR005W)|FD-Score:4.88|P-value:5.30E-7|Clearance:0.01||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:TAF11(YML015C)|FD-Score:-4.01|P-value:3.07E-5|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:UGP1(YKL035W)|FD-Score:4.02|P-value:2.89E-5|Clearance:0.02||SGD DESC:UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication Gene:UTP15(YMR093W)|FD-Score:3.94|P-value:4.07E-5|Clearance:0.06||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:UTP18(YJL069C)|FD-Score:4.87|P-value:5.62E-7|Clearance:0.62||SGD DESC:Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data Gene:VRG4(YGL225W)|FD-Score:3.88|P-value:5.18E-5|Clearance:0.05||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:HIP1(YGR191W)|FD-Score:3.44|P-value:2.95E-4|Clearance:0.05||SGD DESC:High-affinity histidine permease, also involved in the transport of manganese ions Gene:HSH49(YOR319W)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.12||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:LSM2(YBL026W)|FD-Score:3.22|P-value:6.38E-4|Clearance:0.17||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:NAT2(YGR147C)|FD-Score:-3.29|P-value:5.06E-4|Clearance:0||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOG2(YNR053C)|FD-Score:4|P-value:3.12E-5|Clearance:0.03||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:PMI40(YER003C)|FD-Score:6.18|P-value:3.23E-10|Clearance:0.8||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:POL31(YJR006W)|FD-Score:4.24|P-value:1.10E-5|Clearance:0.22||SGD DESC:Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair Gene:PRP28(YDR243C)|FD-Score:3.49|P-value:2.45E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:PRP46(YPL151C)|FD-Score:3.79|P-value:7.40E-5|Clearance:0.04||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:RFC3(YNL290W)|FD-Score:3.24|P-value:5.96E-4|Clearance:0.02||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPB10(YOR210W)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.07||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPB3(YIL021W)|FD-Score:6|P-value:9.82E-10|Clearance:0.8||SGD DESC:RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit Gene:RPB7(YDR404C)|FD-Score:3.69|P-value:1.12E-4|Clearance:0.03||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RRP9(YPR137W)|FD-Score:5.68|P-value:6.75E-9|Clearance:0.8||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RSC9(YML127W)|FD-Score:3.66|P-value:1.27E-4|Clearance:0.17||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:RSE1(YML049C)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport Gene:SCC4(YER147C)|FD-Score:-4.5|P-value:3.40E-6|Clearance:0||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SDS22(YKL193C)|FD-Score:3.97|P-value:3.59E-5|Clearance:0.03||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SEC16(YPL085W)|FD-Score:-4.26|P-value:1.02E-5|Clearance:0||SGD DESC:COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p Gene:SEC31(YDL195W)|FD-Score:3.38|P-value:3.58E-4|Clearance:0.02||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SPB4(YFL002C)|FD-Score:3.84|P-value:6.27E-5|Clearance:0.04||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:SSL1(YLR005W)|FD-Score:4.88|P-value:5.30E-7|Clearance:0.01||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:TAF11(YML015C)|FD-Score:-4.01|P-value:3.07E-5|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:UGP1(YKL035W)|FD-Score:4.02|P-value:2.89E-5|Clearance:0.02||SGD DESC:UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication Gene:UTP15(YMR093W)|FD-Score:3.94|P-value:4.07E-5|Clearance:0.06||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:UTP18(YJL069C)|FD-Score:4.87|P-value:5.62E-7|Clearance:0.62||SGD DESC:Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data Gene:VRG4(YGL225W)|FD-Score:3.88|P-value:5.18E-5|Clearance:0.05||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5384001
Download HOP data (tab-delimited text)  (excel)
Gene:ADH2(YMR303C)|FD-Score:-5.11|P-value:1.60E-7||SGD DESC:Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 Gene:BTS1(YPL069C)|FD-Score:-3.31|P-value:4.64E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COT1(YOR316C)|FD-Score:-3.25|P-value:5.79E-4||SGD DESC:Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication Gene:CTA1(YDR256C)|FD-Score:3.76|P-value:8.36E-5||SGD DESC:Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation Gene:CTF8(YHR191C)|FD-Score:-3.33|P-value:4.30E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CTK3(YML112W)|FD-Score:-3.37|P-value:3.75E-4||SGD DESC:Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress Gene:ECM19(YLR390W)|FD-Score:-3.89|P-value:4.92E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:EMI2(YDR516C)|FD-Score:5.51|P-value:1.78E-8||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:ERI1(YPL096C-A)|FD-Score:-3.49|P-value:2.42E-4||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:FMP30(YPL103C)|FD-Score:3.88|P-value:5.30E-5||SGD DESC:Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D Gene:FPR4(YLR449W)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FUI1(YBL042C)|FD-Score:4.41|P-value:5.25E-6||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GET2(YER083C)|FD-Score:-4.69|P-value:1.34E-6||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GND1(YHR183W)|FD-Score:3.19|P-value:7.01E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication Gene:GUT1(YHL032C)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:HOT13(YKL084W)|FD-Score:-3.45|P-value:2.81E-4||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:HPF1(YOL155C)|FD-Score:3.6|P-value:1.57E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:IRC21(YMR073C)|FD-Score:3.29|P-value:4.99E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:KDX1(YKL161C)|FD-Score:3.87|P-value:5.41E-5||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:LSC2(YGR244C)|FD-Score:4.6|P-value:2.09E-6||SGD DESC:Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Gene:MFB1(YDR219C)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding Gene:MON1(YGL124C)|FD-Score:-4.91|P-value:4.51E-7||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MSF1(YPR047W)|FD-Score:3.1|P-value:9.56E-4||SGD DESC:Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase Gene:MTG2(YHR168W)|FD-Score:3.9|P-value:4.89E-5||SGD DESC:Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly Gene:NDJ1(YOL104C)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:PAU4(YLR461W)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PDR18(YNR070W_p)|FD-Score:-3.16|P-value:7.92E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PHD1(YKL043W)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication Gene:PHO90(YJL198W)|FD-Score:-3.24|P-value:6.01E-4||SGD DESC:Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication Gene:POA1(YBR022W)|FD-Score:3.73|P-value:9.45E-5||SGD DESC:Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing Gene:PYC1(YGL062W)|FD-Score:-3.21|P-value:6.61E-4||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication Gene:RDS1(YCR106W)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:REV7(YIL139C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:RKM1(YPL208W)|FD-Score:4.51|P-value:3.23E-6||SGD DESC:SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) Gene:ROM2(YLR371W)|FD-Score:4.81|P-value:7.66E-7||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPH1(YER169W)|FD-Score:-4.42|P-value:4.90E-6||SGD DESC:JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication Gene:RPL13A(YDL082W)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication Gene:RPL1B(YGL135W)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal Gene:RPL35B(YDL136W)|FD-Score:-3.22|P-value:6.49E-4||SGD DESC:Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAP1(YER047C)|FD-Score:-5.06|P-value:2.08E-7||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SFG1(YOR315W)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate Gene:SIC1(YLR079W)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 Gene:SLY41(YOR307C)|FD-Score:7.84|P-value:2.25E-15||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SOP4(YJL192C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER Gene:SPR6(YER115C)|FD-Score:-5.1|P-value:1.70E-7||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SPS1(YDR523C)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis Gene:SRB5(YGR104C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SRY1(YKL218C)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity Gene:STP22(YCL008C)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype Gene:TGL5(YOR081C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate Gene:TOM6(YOR045W)|FD-Score:-3.1|P-value:9.80E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TRP3(YKL211C)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSR3(YOR006C)|FD-Score:-3.48|P-value:2.53E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UBC12(YLR306W)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:URM1(YIL008W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VBA5(YKR105C_p)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p Gene:YBR113W(YBR113W_d)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 Gene:YDL211C(YDL211C_p)|FD-Score:3.93|P-value:4.19E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YDR094W(YDR094W_d)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Gene:YDR157W(YDR157W_d)|FD-Score:4.73|P-value:1.15E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR169C-A(YDR169C-A_p)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR273C(YGR273C_p)|FD-Score:4.62|P-value:1.88E-6||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YIL161W(YIL161W_p)|FD-Score:-3.2|P-value:6.98E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene Gene:YIR016W(YIR016W_p)|FD-Score:4.43|P-value:4.71E-6||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YLR012C(YLR012C_p)|FD-Score:-5.15|P-value:1.29E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR031W(YLR031W_p)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Putative protein of unknown function Gene:YLR428C(YLR428C_d)|FD-Score:3.3|P-value:4.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR007W(YMR007W_d)|FD-Score:3.82|P-value:6.73E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR085W(YMR085W_p)|FD-Score:7.42|P-value:5.97E-14||SGD DESC:Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YMR086C-A(YMR086C-A_d)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL097C-B(YNL097C-B_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Putative protein of unknown function Gene:YNL193W(YNL193W_p)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YOL085C(YOL085C_d)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YOL162W(YOL162W_p)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR105W(YOR105W_p)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YPL035C(YPL035C_d)|FD-Score:3.78|P-value:7.96E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL088W(YPL088W_p)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YPL108W(YPL108W_p)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:ADH2(YMR303C)|FD-Score:-5.11|P-value:1.60E-7||SGD DESC:Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 Gene:BTS1(YPL069C)|FD-Score:-3.31|P-value:4.64E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COT1(YOR316C)|FD-Score:-3.25|P-value:5.79E-4||SGD DESC:Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication Gene:CTA1(YDR256C)|FD-Score:3.76|P-value:8.36E-5||SGD DESC:Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation Gene:CTF8(YHR191C)|FD-Score:-3.33|P-value:4.30E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CTK3(YML112W)|FD-Score:-3.37|P-value:3.75E-4||SGD DESC:Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress Gene:ECM19(YLR390W)|FD-Score:-3.89|P-value:4.92E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:EMI2(YDR516C)|FD-Score:5.51|P-value:1.78E-8||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:ERI1(YPL096C-A)|FD-Score:-3.49|P-value:2.42E-4||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:FMP30(YPL103C)|FD-Score:3.88|P-value:5.30E-5||SGD DESC:Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D Gene:FPR4(YLR449W)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FUI1(YBL042C)|FD-Score:4.41|P-value:5.25E-6||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GET2(YER083C)|FD-Score:-4.69|P-value:1.34E-6||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GND1(YHR183W)|FD-Score:3.19|P-value:7.01E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication Gene:GUT1(YHL032C)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:HOT13(YKL084W)|FD-Score:-3.45|P-value:2.81E-4||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:HPF1(YOL155C)|FD-Score:3.6|P-value:1.57E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:IRC21(YMR073C)|FD-Score:3.29|P-value:4.99E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:KDX1(YKL161C)|FD-Score:3.87|P-value:5.41E-5||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:LSC2(YGR244C)|FD-Score:4.6|P-value:2.09E-6||SGD DESC:Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Gene:MFB1(YDR219C)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding Gene:MON1(YGL124C)|FD-Score:-4.91|P-value:4.51E-7||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MSF1(YPR047W)|FD-Score:3.1|P-value:9.56E-4||SGD DESC:Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase Gene:MTG2(YHR168W)|FD-Score:3.9|P-value:4.89E-5||SGD DESC:Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly Gene:NDJ1(YOL104C)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:PAU4(YLR461W)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PDR18(YNR070W_p)|FD-Score:-3.16|P-value:7.92E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PHD1(YKL043W)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication Gene:PHO90(YJL198W)|FD-Score:-3.24|P-value:6.01E-4||SGD DESC:Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication Gene:POA1(YBR022W)|FD-Score:3.73|P-value:9.45E-5||SGD DESC:Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing Gene:PYC1(YGL062W)|FD-Score:-3.21|P-value:6.61E-4||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication Gene:RDS1(YCR106W)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:REV7(YIL139C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:RKM1(YPL208W)|FD-Score:4.51|P-value:3.23E-6||SGD DESC:SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) Gene:ROM2(YLR371W)|FD-Score:4.81|P-value:7.66E-7||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPH1(YER169W)|FD-Score:-4.42|P-value:4.90E-6||SGD DESC:JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication Gene:RPL13A(YDL082W)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication Gene:RPL1B(YGL135W)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal Gene:RPL35B(YDL136W)|FD-Score:-3.22|P-value:6.49E-4||SGD DESC:Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:4.1|P-value:2.05E-5||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAP1(YER047C)|FD-Score:-5.06|P-value:2.08E-7||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SFG1(YOR315W)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate Gene:SIC1(YLR079W)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 Gene:SLY41(YOR307C)|FD-Score:7.84|P-value:2.25E-15||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SOP4(YJL192C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER Gene:SPR6(YER115C)|FD-Score:-5.1|P-value:1.70E-7||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SPS1(YDR523C)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis Gene:SRB5(YGR104C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SRY1(YKL218C)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity Gene:STP22(YCL008C)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype Gene:TGL5(YOR081C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate Gene:TOM6(YOR045W)|FD-Score:-3.1|P-value:9.80E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TRP3(YKL211C)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSR3(YOR006C)|FD-Score:-3.48|P-value:2.53E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UBC12(YLR306W)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Gene:URM1(YIL008W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VBA5(YKR105C_p)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p Gene:YBR113W(YBR113W_d)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 Gene:YDL211C(YDL211C_p)|FD-Score:3.93|P-value:4.19E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YDR094W(YDR094W_d)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Gene:YDR157W(YDR157W_d)|FD-Score:4.73|P-value:1.15E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR169C-A(YDR169C-A_p)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR273C(YGR273C_p)|FD-Score:4.62|P-value:1.88E-6||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YIL161W(YIL161W_p)|FD-Score:-3.2|P-value:6.98E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene Gene:YIR016W(YIR016W_p)|FD-Score:4.43|P-value:4.71E-6||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YLR012C(YLR012C_p)|FD-Score:-5.15|P-value:1.29E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR031W(YLR031W_p)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Putative protein of unknown function Gene:YLR428C(YLR428C_d)|FD-Score:3.3|P-value:4.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR007W(YMR007W_d)|FD-Score:3.82|P-value:6.73E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR085W(YMR085W_p)|FD-Score:7.42|P-value:5.97E-14||SGD DESC:Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YMR086C-A(YMR086C-A_d)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL097C-B(YNL097C-B_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Putative protein of unknown function Gene:YNL193W(YNL193W_p)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YOL085C(YOL085C_d)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YOL162W(YOL162W_p)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR105W(YOR105W_p)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YPL035C(YPL035C_d)|FD-Score:3.78|P-value:7.96E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL088W(YPL088W_p)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YPL108W(YPL108W_p)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER003C6.183.23E-100.80PMI40Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YIL021W6.009.82E-100.80RPB3RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YPR137W5.686.75E-90.80RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YLR005W4.885.30E-70.01SSL1Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YJL069C4.875.62E-70.62UTP18Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YJR006W4.241.10E-50.22POL31Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
YKL035W4.022.89E-50.02UGP1UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
YNR053C4.003.12E-50.03NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YKL193C3.973.59E-50.03SDS22Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
YMR093W3.944.07E-50.06UTP15Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGL225W3.885.18E-50.05VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YFL002C3.846.27E-50.04SPB4Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YPL151C3.797.40E-50.04PRP46Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YOR210W3.768.61E-50.07RPB10RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
YDR404C3.691.12E-40.03RPB7RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR307C7.842.25E-15SLY41Protein involved in ER-to-Golgi transport
YMR085W_p7.425.97E-14YMR085W_pPutative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
YDR516C5.511.78E-8EMI2Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YLR371W4.817.66E-7ROM2GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p
YDR157W_d4.731.15E-6YDR157W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR273C_p4.621.88E-6YGR273C_pPutative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
YGR244C4.602.09E-6LSC2Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YPL208W4.513.23E-6RKM1SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
YIR016W_p4.434.71E-6YIR016W_pPutative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
YBL042C4.415.25E-6FUI1High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress
YLR079W4.405.40E-6SIC1Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
YNL213C4.102.05E-5RRG9Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL211C_p3.934.19E-5YDL211C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR306W3.904.86E-5UBC12Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
YHR168W3.904.89E-5MTG2Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly

GO enrichment analysis for SGTC_2768
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0807.00E-10SGTC_20415107442 45.3 μMChembridge (Fragment library)7930050.0909091RSC complex & mRNA processing
0.0714.00E-8SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.0588235RSC complex & mRNA processing
0.0714.32E-8SGTC_3883',4'-dichloroisocoumarin 16.7 μMMiscellaneous16090.0967742
0.0681.93E-7SGTC_2555cholic acid 100.0 μMMicrosource (Natural product library)67086570.0416667
0.0672.13E-7SGTC_546peri-Naphthalide 147.0 μMChemDiv (Drug-like library)2238240.0746269DNA damage response
0.0673.10E-7SGTC_1960st011366 51.8 μMTimTec (Natural product derivative library)39728460.105882
0.0648.72E-7SGTC_13742889-5571 141.0 μMChemDiv (Drug-like library)28532810.0886076RSC complex & mRNA processing
0.0631.14E-6SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.1RSC complex & mRNA processing
0.0621.64E-6SGTC_23789074213 121.4 μMChembridge (Fragment library)6577140.0588235RSC complex & mRNA processing
0.0612.92E-6SGTC_1644st010134 20.9 μMTimTec (Natural product derivative library)38181340.0789474mitochondrial processes
0.0586.96E-6SGTC_32779138724 49.5 μMChembridge (Drug-like library)159434180.0547945Golgi
0.0587.08E-6SGTC_5671080-0542 68.4 μMChemDiv (Drug-like library)59504150.166667
0.0587.18E-6SGTC_9113456-4043 236.0 μMChemDiv (Drug-like library)9142810.0875mitochondrial processes
0.0587.71E-6SGTC_12290139-0193 12.2 μMChemDiv (Drug-like library)30907520.0307692RSC complex & mRNA processing
0.0587.77E-6SGTC_8241304-0008 100.0 μMChemDiv (Drug-like library)7682450.0327869DNA damage response

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1642st00958277.7 μM0.4035096739311TimTec (Natural product derivative library)257.241441.48735RPP1 & pyrimidine depletion
SGTC_7851270-011165.3 μM0.3709686741994ChemDiv (Drug-like library)307.300122.53735
SGTC_7700389-112167.2 μM0.3376626753108ChemDiv (Drug-like library)464.49373.42529RPP1 & pyrimidine depletion
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.3269237104TimTec (Natural product derivative library)188.179422.12623
SGTC_2235salicylic acid500 μM0.326531338Miscellaneous138.120741.21723
SGTC_8550428-002025 μM0.3214296812414ChemDiv (Drug-like library)226.23072.15914Golgi
SGTC_3031348-166834.2 μM0.317465380509ChemDiv (Drug-like library)292.13131.61324
SGTC_23217390090138.78 μM0.311475649046Chembridge (Fragment library)214.263062.85423
SGTC_1571348-169565.82 μM0.3064525380510ChemDiv (Drug-like library)229.234640.62335iron homeostasis
SGTC_3191348-159645.5 μM0.3050855380505ChemDiv (Drug-like library)213.235241.1624RSC & ERG11