Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR307C | 7.84 | 2.25E-15 | SLY41 | Protein involved in ER-to-Golgi transport |
YMR085W_p | 7.42 | 5.97E-14 | YMR085W_p | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 |
YDR516C | 5.51 | 1.78E-8 | EMI2 | Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YLR371W | 4.81 | 7.66E-7 | ROM2 | GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p |
YDR157W_d | 4.73 | 1.15E-6 | YDR157W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YGR273C_p | 4.62 | 1.88E-6 | YGR273C_p | Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene |
YGR244C | 4.60 | 2.09E-6 | LSC2 | Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate |
YPL208W | 4.51 | 3.23E-6 | RKM1 | SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) |
YIR016W_p | 4.43 | 4.71E-6 | YIR016W_p | Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication |
YBL042C | 4.41 | 5.25E-6 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
YLR079W | 4.40 | 5.40E-6 | SIC1 | Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 |
YNL213C | 4.10 | 2.05E-5 | RRG9 | Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YDL211C_p | 3.93 | 4.19E-5 | YDL211C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
YLR306W | 3.90 | 4.86E-5 | UBC12 | Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes |
YHR168W | 3.90 | 4.89E-5 | MTG2 | Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly |