Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJL056C | 6.01 | 9.33E-10 | ZAP1 | Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains |
YMR001C-A_p | 5.93 | 1.52E-9 | YMR001C-A_p | Putative protein of unknown function |
YBL008W-A_p | 5.86 | 2.34E-9 | YBL008W-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YOL085C_d | 5.79 | 3.49E-9 | YOL085C_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A |
YLR028C | 5.58 | 1.21E-8 | ADE16 | Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine |
YGL071W | 5.54 | 1.54E-8 | AFT1 | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YLR426W_p | 5.47 | 2.31E-8 | TDA5_p | Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele |
YEL063C | 5.23 | 8.68E-8 | CAN1 | Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication |
YOL001W | 4.85 | 6.17E-7 | PHO80 | Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling |
YDR291W_p | 4.74 | 1.04E-6 | HRQ1_p | 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) |
YFL047W | 4.62 | 1.89E-6 | RGD2 | GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YBR006W | 4.55 | 2.71E-6 | UGA2 | Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm |
YML006C | 4.50 | 3.47E-6 | GIS4 | CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway |
YOL119C | 4.39 | 5.69E-6 | MCH4 | Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport |
YKL146W | 4.38 | 5.96E-6 | AVT3 | Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |