Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR413C_d | 5.92 | 1.61E-9 | 1.65 | YDR413C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing |
YBR153W | 4.27 | 9.75E-6 | 0.21 | RIB7 | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |
YJL069C | 4.06 | 2.45E-5 | 0.83 | UTP18 | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data |
YBR004C | 3.23 | 6.15E-4 | 0.06 | GPI18 | Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria |
YKL099C | 3.18 | 7.46E-4 | 0.03 | UTP11 | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
YAL003W | 3.14 | 8.40E-4 | 0.33 | EFB1 | Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site |
YOR203W_d | 2.81 | 0.00248 | 0.04 | YOR203W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation |
YIL078W | 2.78 | 0.00276 | 0.14 | THS1 | Threonyl-tRNA synthetase, essential cytoplasmic protein |
YOR260W | 2.63 | 0.00422 | 0.02 | GCD1 | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YPL233W | 2.61 | 0.00453 | 0.18 | NSL1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation |
YMR211W | 2.43 | 0.00752 | 0.00 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YER159C | 2.43 | 0.00755 | 0.02 | BUR6 | Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha |
YPR161C | 2.41 | 0.00800 | 0.05 | SGV1 | Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins |
YGR002C | 2.36 | 0.00926 | 0.08 | SWC4 | Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex |
YPR137W | 2.28 | 0.01140 | 0.02 | RRP9 | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |