Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YER022W | 9.44 | 1.79E-21 | 4.25 | SRB4 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination |
YOL077C | 5.19 | 1.04E-7 | 0.03 | BRX1 | Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif |
YOR095C | 5.16 | 1.21E-7 | 0.10 | RKI1 | Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis |
YDR187C_d | 5.06 | 2.08E-7 | 0.04 | YDR187C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W |
YLR010C | 5.02 | 2.58E-7 | 0.11 | TEN1 | Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p |
YJR022W | 4.91 | 4.48E-7 | 0.90 | LSM8 | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA |
YOR319W | 4.01 | 3.00E-5 | 0.01 | HSH49 | U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) |
YPL218W | 4.01 | 3.09E-5 | 0.08 | SAR1 | GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport |
YKL196C | 3.92 | 4.40E-5 | 0.23 | YKT6 | Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus |
YLL011W | 3.69 | 1.13E-4 | 0.05 | SOF1 | Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p |
YDL195W | 3.64 | 1.38E-4 | 0.02 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YPR169W | 3.62 | 1.50E-4 | 0.19 | JIP5 | Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein |
YJR067C | 3.42 | 3.09E-4 | 0.08 | YAE1 | Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
YHR062C | 3.34 | 4.12E-4 | 0.05 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YPR136C_d | 3.29 | 5.00E-4 | 0.11 | YPR136C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 |