| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YKL181W | 9.59 | 4.48E-22 | PRS1 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
| YHR108W | 7.56 | 2.00E-14 | GGA2 | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
| YFR043C | 6.72 | 9.00E-12 | IRC6 | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
| YGL060W | 6.57 | 2.46E-11 | YBP2 | Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication |
| YJR113C | 6.11 | 5.08E-10 | RSM7 | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein |
| YJL155C | 5.92 | 1.62E-9 | FBP26 | Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress |
| YOR115C | 5.81 | 3.21E-9 | TRS33 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |
| YBR266C_d | 5.80 | 3.36E-9 | SLM6_d | Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase |
| YMR234W | 5.50 | 1.94E-8 | RNH1 | Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) |
| YNL277W-A_p | 5.42 | 2.97E-8 | YNL277W-A_p | Putative protein of unknown function |
| YBR262C | 5.39 | 3.55E-8 | AIM5 | Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
| YPL145C | 5.32 | 5.06E-8 | KES1 | One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication |
| YGR106C | 5.30 | 5.85E-8 | VOA1 | Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval |
| YGR072W | 4.28 | 9.29E-6 | UPF3 | Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance |
| YBL060W | 4.24 | 1.12E-5 | YEL1 | Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip |
