1672-3440

2-[4-[(3,5-dibromo-6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]phenyl]sulfonylguanidine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_281
Screen concentration 14.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 6833000
SMILES C1=CC(=CC=C1NC=C2C=C(C=C(C2=O)Br)Br)S(=O)(=O)N=C(N)N
Standardized SMILES NC(=N)NS(=O)(=O)c1ccc(cc1)N=Cc2cc(Br)cc(Br)c2O
Molecular weight 476.1431
ALogP 0.9
H-bond donor count 3
H-bond acceptor count 5
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.47
% growth inhibition (Hom. pool) 5.65


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6833000
Download HIP data (tab-delimited text)  (excel)
Gene:AAR2(YBL074C)|FD-Score:3.41|P-value:3.25E-4|Clearance:0.2||SGD DESC:Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron Gene:CET1(YPL228W)|FD-Score:3.15|P-value:8.23E-4|Clearance:0.02||SGD DESC:Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide Gene:HCA4(YJL033W)|FD-Score:-3.38|P-value:3.65E-4|Clearance:0||SGD DESC:DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis Gene:RSC6(YCR052W)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:UBA2(YDR390C)|FD-Score:3.21|P-value:6.61E-4|Clearance:0.06||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YGL102C(YGL102C_d)|FD-Score:3.12|P-value:8.92E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Gene:AAR2(YBL074C)|FD-Score:3.41|P-value:3.25E-4|Clearance:0.2||SGD DESC:Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron Gene:CET1(YPL228W)|FD-Score:3.15|P-value:8.23E-4|Clearance:0.02||SGD DESC:Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide Gene:HCA4(YJL033W)|FD-Score:-3.38|P-value:3.65E-4|Clearance:0||SGD DESC:DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis Gene:RSC6(YCR052W)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:UBA2(YDR390C)|FD-Score:3.21|P-value:6.61E-4|Clearance:0.06||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YGL102C(YGL102C_d)|FD-Score:3.12|P-value:8.92E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6833000
Download HOP data (tab-delimited text)  (excel)
Gene:ARA1(YBR149W)|FD-Score:-3.18|P-value:7.24E-4||SGD DESC:NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product Gene:AST2(YER101C)|FD-Score:3.22|P-value:6.48E-4||SGD DESC:Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication Gene:COG7(YGL005C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:3.74|P-value:9.21E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC27(YPL064C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress Gene:DGR1(YNL130C-A_p)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose Gene:EBS1(YDR206W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:ECM23(YPL021W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p Gene:FUS1(YCL027W)|FD-Score:4.96|P-value:3.55E-7||SGD DESC:Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate Gene:GET2(YER083C)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:HHF1(YBR009C)|FD-Score:-3.48|P-value:2.52E-4||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:IRS4(YKR019C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MCH2(YKL221W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:PNP1(YLR209C)|FD-Score:-3.95|P-value:3.86E-5||SGD DESC:Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway Gene:PRK1(YIL095W)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication Gene:RPS26B(YER131W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication Gene:SPE1(YKL184W)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SRC1(YML034W)|FD-Score:5.5|P-value:1.90E-8||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:TLG2(YOL018C)|FD-Score:4.11|P-value:1.95E-5||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VAM7(YGL212W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress Gene:YBR300C(YBR300C_d)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YDR133C(YDR133C_d)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Gene:YFL040W(YFL040W_p)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Putative transporter, member of the sugar porter family; YFL040W is not an essential gene Gene:YIH1(YCR059C)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YKL162C(YKL162C_p)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YNL042W-B(YNL042W-B_p)|FD-Score:4.59|P-value:2.24E-6||SGD DESC:Putative protein of unknown function Gene:YOR034C-A(YOR034C-A_p)|FD-Score:3.14|P-value:8.33E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR062C(YOR062C_p)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YPT6(YLR262C)|FD-Score:4.99|P-value:2.99E-7||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:ARA1(YBR149W)|FD-Score:-3.18|P-value:7.24E-4||SGD DESC:NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product Gene:AST2(YER101C)|FD-Score:3.22|P-value:6.48E-4||SGD DESC:Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication Gene:COG7(YGL005C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:3.74|P-value:9.21E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC27(YPL064C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress Gene:DGR1(YNL130C-A_p)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose Gene:EBS1(YDR206W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:ECM23(YPL021W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p Gene:FUS1(YCL027W)|FD-Score:4.96|P-value:3.55E-7||SGD DESC:Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate Gene:GET2(YER083C)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:HHF1(YBR009C)|FD-Score:-3.48|P-value:2.52E-4||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:IRS4(YKR019C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MCH2(YKL221W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:PNP1(YLR209C)|FD-Score:-3.95|P-value:3.86E-5||SGD DESC:Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway Gene:PRK1(YIL095W)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication Gene:RPS26B(YER131W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication Gene:SPE1(YKL184W)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SRC1(YML034W)|FD-Score:5.5|P-value:1.90E-8||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:TLG2(YOL018C)|FD-Score:4.11|P-value:1.95E-5||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VAM7(YGL212W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress Gene:YBR300C(YBR300C_d)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YDR133C(YDR133C_d)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Gene:YFL040W(YFL040W_p)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Putative transporter, member of the sugar porter family; YFL040W is not an essential gene Gene:YIH1(YCR059C)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YKL162C(YKL162C_p)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YNL042W-B(YNL042W-B_p)|FD-Score:4.59|P-value:2.24E-6||SGD DESC:Putative protein of unknown function Gene:YOR034C-A(YOR034C-A_p)|FD-Score:3.14|P-value:8.33E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR062C(YOR062C_p)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YPT6(YLR262C)|FD-Score:4.99|P-value:2.99E-7||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCR052W3.681.16E-40.27RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YBL074C3.413.25E-40.20AAR2Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YDR390C3.216.61E-40.06UBA2Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YPL228W3.158.23E-40.02CET1Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YGL102C_d3.128.92E-40.08YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YHR007C3.050.001160.07ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YOR319W2.970.001480.10HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YDL212W2.870.002060.05SHR3Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YHR166C2.820.002390.06CDC23Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YLR298C2.760.002910.15YHC1Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YLR105C2.610.004590.03SEN2Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YPR010C2.570.005010.00RPA135RNA polymerase I second largest subunit A135
YKR004C2.570.005040.02ECM9Non-essential protein of unknown function
YML127W2.550.005340.01RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YPL010W2.540.005490.01RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML034W5.501.90E-8SRC1Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
YLR262C4.992.99E-7YPT6Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YCL027W4.963.55E-7FUS1Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YNL042W-B_p4.592.24E-6YNL042W-B_pPutative protein of unknown function
YOL018C4.111.95E-5TLG2Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
YML071C3.749.21E-5COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YCR059C3.631.42E-4YIH1Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT
YKL184W3.581.71E-4SPE1Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
YPL021W3.532.11E-4ECM23Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YNL130C-A_p3.512.24E-4DGR1_pProtein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
YKL221W3.482.49E-4MCH2Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YGL212W3.452.77E-4VAM7Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
YGL005C3.433.00E-4COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YER083C3.363.96E-4GET2Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
YKL162C_p3.353.99E-4YKL162C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion

GO enrichment analysis for SGTC_281
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1997.86E-54SGTC_3061672-3436 11.6 μMChemDiv (Drug-like library)67973780.555556Golgi
0.1825.01E-45SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.0869565Golgi
0.1719.51E-40SGTC_590k048-0076 22.4 μMChemDiv (Drug-like library)68328140.464286RSC & ERG11
0.1611.68E-35SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.387097RSC & ERG11
0.1503.57E-31SGTC_459nigericin 15.3 μMICCB bioactive library342300.0243902
0.1403.51E-27SGTC_980074-0023 107.7 μMChemDiv (Drug-like library)35638210.084507Golgi
0.1403.91E-27SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.519231Golgi
0.1397.42E-27SGTC_2737bleomycin 30.5 nMMiscellaneous162113180.0444444Golgi
0.1382.37E-26SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.328571Golgi
0.1373.05E-26SGTC_13061185-0270 9.0 μMChemDiv (Drug-like library)15480760.0405405Golgi
0.1374.99E-26SGTC_31669102297 49.5 μMChembridge (Drug-like library)252370720.133333Golgi
0.1315.46E-24SGTC_1139k015-0024 46.9 μMChemDiv (Drug-like library)27666520.0649351PDR1
0.1314.97E-24SGTC_1078idebenone 36.1 μMMiscellaneous36860.0422535Golgi
0.1316.19E-24SGTC_1669st015249 58.4 μMTimTec (Natural product derivative library)7227930.0897436Golgi
0.1292.74E-23SGTC_7981287-0182 476.0 μMChemDiv (Drug-like library)16497550.181818

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3061672-343611.6 μM0.5555566797378ChemDiv (Drug-like library)542.201162.93628Golgi
SGTC_1162k048-013020.1 μM0.5192316797406ChemDiv (Drug-like library)431.120624.52312Golgi
SGTC_590k048-007622.4 μM0.4642866832814ChemDiv (Drug-like library)407.4601833.87413RSC & ERG11
SGTC_331k048-013324.5 μM0.4464296813582ChemDiv (Drug-like library)356.012721.85413RSC & ERG11
SGTC_643k048-010628.4 μM0.4406786763920ChemDiv (Drug-like library)419.49573.65213RSC & ERG11
SGTC_203k066-000430.89 μM0.4333336795412ChemDiv (Drug-like library)501.165862.52816RSC & ERG11
SGTC_13531498-12068.11 μM0.4259266756808ChemDiv (Drug-like library)371.024062.76223mitochondrial response to ROS
SGTC_5660958-006816.5 μM0.4242426815365ChemDiv (Drug-like library)492.1358233.99424RSC & ERG11
SGTC_4300958-011516.4 μM0.417916833180ChemDiv (Drug-like library)508.590424.45323
SGTC_329k048-012121.3 μM0.4107146832902ChemDiv (Drug-like library)480.921193.58212RSC & ERG11