Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL186C | 9.16 | 2.60E-20 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YNL097C | 6.95 | 1.76E-12 | PHO23 | Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 |
YGR162W | 6.89 | 2.79E-12 | TIF4631 | Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication |
YOL076W | 6.83 | 4.12E-12 | MDM20 | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly |
YNL071W | 6.12 | 4.70E-10 | LAT1 | Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA |
YMR293C | 5.88 | 2.00E-9 | HER2 | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase |
YLR123C_d | 5.82 | 2.96E-9 | YLR123C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif |
YLR254C | 5.71 | 5.73E-9 | NDL1 | Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends |
YLL005C | 5.60 | 1.10E-8 | SPO75 | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis |
YPR084W_p | 5.59 | 1.11E-8 | YPR084W_p | Putative protein of unknown function |
YDR535C_d | 5.57 | 1.27E-8 | YDR535C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. |
YDR536W | 5.50 | 1.91E-8 | STL1 | Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
YMR052W | 5.50 | 1.93E-8 | FAR3 | Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress |
YDR525W-A | 5.33 | 4.79E-8 | SNA2 | Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
YLR184W_d | 5.28 | 6.49E-8 | YLR184W_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |