Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YDR435C | 11.40 | 3.10E-30 | PPM1 | Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits |
YDL041W_d | 6.96 | 1.69E-12 | YDL041W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C |
YOL018C | 6.79 | 5.50E-12 | TLG2 | Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) |
YCR044C | 6.75 | 7.26E-12 | PER1 | Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 |
YNL196C_p | 6.62 | 1.76E-11 | SLZ1_p | Sporulation-specific protein with a leucine zipper motif |
YMR052W | 6.14 | 4.09E-10 | FAR3 | Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress |
YDR263C | 6.11 | 4.94E-10 | DIN7 | Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination |
YPL161C | 5.70 | 5.89E-9 | BEM4 | Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length |
YPL002C | 5.54 | 1.55E-8 | SNF8 | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression |
YPR170C_d | 5.37 | 4.02E-8 | YPR170C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B |
YDR019C | 5.24 | 7.86E-8 | GCV1 | T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm |
YPR012W_d | 5.23 | 8.28E-8 | YPR012W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene |
YBR120C | 5.11 | 1.65E-7 | CBP6 | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
YOR313C | 5.00 | 2.84E-7 | SPS4 | Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage |
YER084W_p | 4.97 | 3.28E-7 | YER084W_p | Protein of unknown function; expressed at both mRNA and protein levels |