Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER176W | 9.89 | 2.23E-23 | ECM32 | DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
YOR105W_p | 7.05 | 8.99E-13 | YOR105W_p | Protein of unknown function; expressed at both mRNA and protein levels |
YML035C | 6.77 | 6.45E-12 | AMD1 | AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools |
YJL093C | 6.42 | 7.02E-11 | TOK1 | Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin |
YOL050C_d | 6.33 | 1.25E-10 | YOL050C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
YOL044W | 6.28 | 1.68E-10 | PEX15 | Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly |
YMR313C | 5.83 | 2.84E-9 | TGL3 | Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation |
YJL183W | 5.81 | 3.09E-9 | MNN11 | Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p |
YPL084W | 5.80 | 3.34E-9 | BRO1 | Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes |
YMR068W | 5.74 | 4.71E-9 | AVO2 | Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth |
YBL007C | 5.63 | 8.81E-9 | SLA1 | Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains |
YML107C | 5.24 | 7.93E-8 | PML39 | Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes |
YDR495C | 5.12 | 1.50E-7 | VPS3 | Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase |
YOR211C | 5.10 | 1.68E-7 | MGM1 | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy |
YGL043W | 5.08 | 1.87E-7 | DST1 | General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress |