9005661

N-(3-chlorophenyl)-2-methyl-2,3-dihydro-1,4-benzodioxine-3-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2847
Screen concentration 71.4 μM
Source Chembridge (Drug-like library)
PubChem CID 2991449
SMILES CC1C(OC2=CC=CC=C2O1)C(=O)NC3=CC(=CC=C3)Cl
Standardized SMILES CC1Oc2ccccc2OC1C(=O)Nc3cccc(Cl)c3
Molecular weight 303.7403
ALogP 3.43
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.83
% growth inhibition (Hom. pool) 11.08


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2991449
Download HIP data (tab-delimited text)  (excel)
Gene:EFB1(YAL003W)|FD-Score:3.63|P-value:1.43E-4|Clearance:0.32||SGD DESC:Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site Gene:FIP1(YJR093C)|FD-Score:-3.26|P-value:5.60E-4|Clearance:0||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:MAK21(YDR060W)|FD-Score:-3.85|P-value:5.91E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein Gene:RPF2(YKR081C)|FD-Score:-3.23|P-value:6.22E-4|Clearance:0||SGD DESC:Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles Gene:RPN7(YPR108W)|FD-Score:-3.2|P-value:6.77E-4|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits Gene:RPP1(YHR062C)|FD-Score:6.69|P-value:1.10E-11|Clearance:3.06||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SLD7(YOR060C)|FD-Score:3.14|P-value:8.55E-4|Clearance:0.3||SGD DESC:Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria Gene:UTP5(YDR398W)|FD-Score:3.31|P-value:4.73E-4|Clearance:0.17||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:EFB1(YAL003W)|FD-Score:3.63|P-value:1.43E-4|Clearance:0.32||SGD DESC:Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site Gene:FIP1(YJR093C)|FD-Score:-3.26|P-value:5.60E-4|Clearance:0||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:MAK21(YDR060W)|FD-Score:-3.85|P-value:5.91E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein Gene:RPF2(YKR081C)|FD-Score:-3.23|P-value:6.22E-4|Clearance:0||SGD DESC:Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles Gene:RPN7(YPR108W)|FD-Score:-3.2|P-value:6.77E-4|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits Gene:RPP1(YHR062C)|FD-Score:6.69|P-value:1.10E-11|Clearance:3.06||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SLD7(YOR060C)|FD-Score:3.14|P-value:8.55E-4|Clearance:0.3||SGD DESC:Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria Gene:UTP5(YDR398W)|FD-Score:3.31|P-value:4.73E-4|Clearance:0.17||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2991449
Download HOP data (tab-delimited text)  (excel)
Gene:ARG80(YMR042W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Gene:BIO2(YGR286C)|FD-Score:4.87|P-value:5.70E-7||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:CAM1(YPL048W)|FD-Score:3.25|P-value:5.76E-4||SGD DESC:Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Gene:CSI1(YMR025W)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome Gene:FET3(YMR058W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress Gene:KRE28(YDR532C)|FD-Score:-3.32|P-value:4.48E-4||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:LOT6(YLR011W)|FD-Score:4.29|P-value:8.79E-6||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:MRH4(YGL064C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRK1(YDL079C)|FD-Score:-4.84|P-value:6.51E-7||SGD DESC:Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation Gene:PCS60(YBR222C)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase Gene:PIB1(YDR313C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain Gene:POC4(YPL144W)|FD-Score:5.57|P-value:1.27E-8||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:PSD2(YGR170W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine Gene:RAD26(YJR035W)|FD-Score:5.66|P-value:7.77E-9||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RIM20(YOR275C)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation Gene:SHG1(YBR258C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres Gene:SHU1(YHL006C)|FD-Score:5.49|P-value:2.04E-8||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SRO77(YBL106C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SWE1(YJL187C)|FD-Score:6.5|P-value:4.04E-11||SGD DESC:Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate Gene:SYO1(YDL063C)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:UBP15(YMR304W)|FD-Score:-3.94|P-value:4.11E-5||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:VAB2(YEL005C)|FD-Score:-4.18|P-value:1.47E-5||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:WWM1(YFL010C)|FD-Score:4.86|P-value:5.81E-7||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YDL180W(YDL180W_p)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YDR250C(YDR250C_d)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YEL025C(YEL025C_p)|FD-Score:3.93|P-value:4.22E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YLR053C(YLR053C_p)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Putative protein of unknown function Gene:YMR122C(YMR122C_d)|FD-Score:-4.43|P-value:4.70E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ARG80(YMR042W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Gene:BIO2(YGR286C)|FD-Score:4.87|P-value:5.70E-7||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:CAM1(YPL048W)|FD-Score:3.25|P-value:5.76E-4||SGD DESC:Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Gene:CSI1(YMR025W)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome Gene:FET3(YMR058W)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress Gene:KRE28(YDR532C)|FD-Score:-3.32|P-value:4.48E-4||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:LOT6(YLR011W)|FD-Score:4.29|P-value:8.79E-6||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:MRH4(YGL064C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRK1(YDL079C)|FD-Score:-4.84|P-value:6.51E-7||SGD DESC:Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation Gene:PCS60(YBR222C)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase Gene:PIB1(YDR313C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain Gene:POC4(YPL144W)|FD-Score:5.57|P-value:1.27E-8||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:PSD2(YGR170W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine Gene:RAD26(YJR035W)|FD-Score:5.66|P-value:7.77E-9||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RIM20(YOR275C)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation Gene:SHG1(YBR258C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres Gene:SHU1(YHL006C)|FD-Score:5.49|P-value:2.04E-8||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SRO77(YBL106C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SWE1(YJL187C)|FD-Score:6.5|P-value:4.04E-11||SGD DESC:Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate Gene:SYO1(YDL063C)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:UBP15(YMR304W)|FD-Score:-3.94|P-value:4.11E-5||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:VAB2(YEL005C)|FD-Score:-4.18|P-value:1.47E-5||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:WWM1(YFL010C)|FD-Score:4.86|P-value:5.81E-7||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YDL180W(YDL180W_p)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YDR250C(YDR250C_d)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YEL025C(YEL025C_p)|FD-Score:3.93|P-value:4.22E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YLR053C(YLR053C_p)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Putative protein of unknown function Gene:YMR122C(YMR122C_d)|FD-Score:-4.43|P-value:4.70E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR062C6.691.10E-113.06RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YAL003W3.631.43E-40.32EFB1Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YDR398W3.314.73E-40.17UTP5Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YOR060C3.148.55E-40.30SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YDR037W2.830.002290.06KRS1Lysyl-tRNA synthetase
YGR116W2.780.002750.20SPT6Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YDR041W2.580.004920.02RSM10Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YGL233W2.560.005260.09SEC15Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
YGR175C2.470.006780.15ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YOL133W2.320.010200.01HRT1RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
YOL134C_d2.310.010500.01YOL134C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
YER136W2.300.010700.02GDI1GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YLR339C_d2.280.011400.02YLR339C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YBR234C2.250.012100.10ARC40Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YJL081C2.160.015600.04ARP4Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJL187C6.504.04E-11SWE1Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YJR035W5.667.77E-9RAD26Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
YPL144W5.571.27E-8POC4Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YHL006C5.492.04E-8SHU1Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
YGR286C4.875.70E-7BIO2Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YFL010C4.865.81E-7WWM1WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YLR011W4.298.79E-6LOT6FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
YMR025W3.983.40E-5CSI1Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
YEL025C_p3.934.22E-5YEL025C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YDR313C3.691.12E-4PIB1RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YDL180W_p3.492.41E-4YDL180W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGL064C3.432.98E-4MRH4Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YGR170W3.432.99E-4PSD2Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
YBR258C3.433.07E-4SHG1Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
YLR053C_p3.403.36E-4YLR053C_pPutative protein of unknown function

GO enrichment analysis for SGTC_2847
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1783.79E-43SGTC_28439000894 45.5 μMChembridge (Drug-like library)22420700.21875
0.1751.14E-41SGTC_28409008771 71.4 μMChembridge (Drug-like library)29929780.133333
0.1322.08E-24SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.0779221RPP1 & pyrimidine depletion
0.1262.91E-22SGTC_265mycophenolic acid 32.9 μMMiscellaneous4465410.075RPP1 & pyrimidine depletion
0.1062.62E-16SGTC_2685mycophenolic acid 18.9 μMMiscellaneous4465410.075RNA pol III & RNase P/MRP
0.1055.12E-16SGTC_20355154463 94.6 μMChembridge (Fragment library)27696230.169231
0.0943.69E-13SGTC_15346-azauridine 81.6 μMTimTec (Pure natural product library)2335020.0724638RNA pol III & RNase P/MRP
0.0945.18E-13SGTC_28399003951 26.0 μMChembridge (Drug-like library)29906340.262295
0.0921.08E-12SGTC_14884013-0813 75.9 μMChemDiv (Drug-like library)29100570.08RPP1 & pyrimidine depletion
0.0903.57E-12SGTC_1642st009582 77.7 μMTimTec (Natural product derivative library)67393110.142857RPP1 & pyrimidine depletion
0.0898.43E-12SGTC_1661st013063 9.7 μMTimTec (Natural product derivative library)7213950.149254
0.0872.71E-11SGTC_466geldanamycin 89.2 μMICCB bioactive library52883820.0792079RPP1 & pyrimidine depletion
0.0856.10E-11SGTC_31699102970 49.5 μMChembridge (Drug-like library)170278390.121212RPP1 & pyrimidine depletion
0.0832.15E-10SGTC_2547epiafzelechin trimethyl ether 100.0 μMMicrosource (Natural product library)67086300.134328
0.0806.06E-10SGTC_28609025725 39.0 μMChembridge (Drug-like library)405462480.223881RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12550566-0045221 μM0.4038462788469ChemDiv (Drug-like library)304.728323.04223excess fatty acid
SGTC_2787528454071.43 μM0.396226736958Chembridge (Drug-like library)291.729563.24613
SGTC_2890904672958.44 μM0.388889903329Chembridge (Drug-like library)270.114662.88412Golgi
SGTC_2942905277762.25 μM0.3846156469503Chembridge (Drug-like library)284.1131234.14912
SGTC_3176910658249.47 μM0.38181817018027Chembridge (Drug-like library)275.730163.74812
SGTC_2900532852885.29 μM0.377358795359Chembridge (Drug-like library)261.703583.26212Golgi
SGTC_2392N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide200 μM0.37037803109Chembridge (Fragment library)248.665061.08522
SGTC_1190121-004324.82 μM0.3636361092378ChemDiv (Drug-like library)405.469124.53322mitochondrial stress
SGTC_2892904735858.44 μM0.3620696466771Chembridge (Drug-like library)379.861122.414
SGTC_1964st07691461 μM0.36065624208661TimTec (Natural product derivative library)327.761663.82714RPP1 & pyrimidine depletion