9024595

N-[2-(4-acetylpiperazin-1-yl)phenyl]-3-chloro-4-ethoxybenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2861
Screen concentration 19.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16482810
SMILES CCOC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2N3CCN(CC3)C(=O)C)Cl
Standardized SMILES CCOc1ccc(cc1Cl)C(=O)Nc2ccccc2N3CCN(CC3)C(=O)C
Molecular weight 401.8866
ALogP 2.99
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.99
% growth inhibition (Hom. pool) 1.13


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16482810
Download HIP data (tab-delimited text)  (excel)
Gene:ATM1(YMR301C)|FD-Score:-3.46|P-value:2.74E-4|Clearance:0||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:NUP85(YJR042W)|FD-Score:-3.48|P-value:2.48E-4|Clearance:0||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:SDO1(YLR022C)|FD-Score:3.16|P-value:7.94E-4|Clearance:0.37||SGD DESC:Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes Gene:ATM1(YMR301C)|FD-Score:-3.46|P-value:2.74E-4|Clearance:0||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:NUP85(YJR042W)|FD-Score:-3.48|P-value:2.48E-4|Clearance:0||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:SDO1(YLR022C)|FD-Score:3.16|P-value:7.94E-4|Clearance:0.37||SGD DESC:Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16482810
Download HOP data (tab-delimited text)  (excel)
Gene:AFG3(YER017C)|FD-Score:-3.97|P-value:3.64E-5||SGD DESC:Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging Gene:AIM17(YHL021C)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ALG8(YOR067C)|FD-Score:-3.12|P-value:9.10E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:CBP1(YJL209W)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress Gene:CTS1(YLR286C)|FD-Score:4.71|P-value:1.23E-6||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DAP2(YHR028C)|FD-Score:-5.21|P-value:9.21E-8||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DBP3(YGL078C)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EIS1(YMR031C)|FD-Score:-3.73|P-value:9.73E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP70(YLR083C)|FD-Score:-3.5|P-value:2.37E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:ERP5(YHR110W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:JHD1(YER051W)|FD-Score:3.73|P-value:9.63E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:LOS1(YKL205W)|FD-Score:-3.43|P-value:2.99E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MAC1(YMR021C)|FD-Score:-3.12|P-value:9.01E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:PPN1(YDR452W)|FD-Score:-4.64|P-value:1.78E-6||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:REV1(YOR346W)|FD-Score:-4.65|P-value:1.63E-6||SGD DESC:Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RNP1(YLL046C)|FD-Score:3.74|P-value:9.38E-5||SGD DESC:Ribonucleoprotein that contains two RNA recognition motifs (RRM) Gene:RPL12B(YDR418W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication Gene:RPL16A(YIL133C)|FD-Score:-3.18|P-value:7.33E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SPG1(YGR236C)|FD-Score:-4.8|P-value:8.00E-7||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SUT2(YPR009W)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:SWC3(YAL011W)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:SYN8(YAL014C)|FD-Score:3.29|P-value:4.95E-4||SGD DESC:Endosomal SNARE related to mammalian syntaxin 8 Gene:TDA9(YML081W)|FD-Score:-4.3|P-value:8.40E-6||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TKL1(YPR074C)|FD-Score:-3.09|P-value:9.91E-4||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:VMA13(YPR036W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:YDR537C(YDR537C_d)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Gene:YET2(YMR040W)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YGR219W(YGR219W_d)|FD-Score:-3.56|P-value:1.82E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Gene:AFG3(YER017C)|FD-Score:-3.97|P-value:3.64E-5||SGD DESC:Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging Gene:AIM17(YHL021C)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ALG8(YOR067C)|FD-Score:-3.12|P-value:9.10E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:CBP1(YJL209W)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress Gene:CTS1(YLR286C)|FD-Score:4.71|P-value:1.23E-6||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DAP2(YHR028C)|FD-Score:-5.21|P-value:9.21E-8||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DBP3(YGL078C)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EIS1(YMR031C)|FD-Score:-3.73|P-value:9.73E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP70(YLR083C)|FD-Score:-3.5|P-value:2.37E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:ERP5(YHR110W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:JHD1(YER051W)|FD-Score:3.73|P-value:9.63E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:LOS1(YKL205W)|FD-Score:-3.43|P-value:2.99E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MAC1(YMR021C)|FD-Score:-3.12|P-value:9.01E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:PPN1(YDR452W)|FD-Score:-4.64|P-value:1.78E-6||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:REV1(YOR346W)|FD-Score:-4.65|P-value:1.63E-6||SGD DESC:Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RNP1(YLL046C)|FD-Score:3.74|P-value:9.38E-5||SGD DESC:Ribonucleoprotein that contains two RNA recognition motifs (RRM) Gene:RPL12B(YDR418W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication Gene:RPL16A(YIL133C)|FD-Score:-3.18|P-value:7.33E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SPG1(YGR236C)|FD-Score:-4.8|P-value:8.00E-7||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SUT2(YPR009W)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:SWC3(YAL011W)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:SYN8(YAL014C)|FD-Score:3.29|P-value:4.95E-4||SGD DESC:Endosomal SNARE related to mammalian syntaxin 8 Gene:TDA9(YML081W)|FD-Score:-4.3|P-value:8.40E-6||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TKL1(YPR074C)|FD-Score:-3.09|P-value:9.91E-4||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:VMA13(YPR036W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:YDR537C(YDR537C_d)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Gene:YET2(YMR040W)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YGR219W(YGR219W_d)|FD-Score:-3.56|P-value:1.82E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR022C3.167.94E-40.37SDO1Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
YDR437W2.790.002650.02GPI19Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P
YKL059C2.770.002830.11MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YEL026W2.660.003920.09SNU13RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YIL091C2.570.005110.07UTP25Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
YPL175W2.500.006170.01SPT14UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
YPL094C2.490.006350.04SEC62Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YOL038W2.450.007100.13PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YOR046C2.320.010000.06DBP5Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
YDL196W_d2.270.011700.07YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YBR091C2.190.014100.06TIM12Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YER172C2.140.016200.02BRR2RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
YPR010C2.120.017000.03RPA135RNA polymerase I second largest subunit A135
YMR270C2.100.018100.02RRN9Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YDR308C2.080.018700.02SRB7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR286C4.711.23E-6CTS1Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
YAL011W4.052.54E-5SWC3Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YLL046C3.749.38E-5RNP1Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YER051W3.739.63E-5JHD1JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
YDR418W3.621.45E-4RPL12BRibosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
YHR110W3.492.45E-4ERP5Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YHL021C3.433.05E-4AIM17Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
YAL014C3.294.95E-4SYN8Endosomal SNARE related to mammalian syntaxin 8
YJL209W3.177.64E-4CBP1Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
YBR181C3.030.00123RPS6BProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
YNL332W3.000.00134THI12Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YNL319W_d2.990.00141YNL319W_dDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
YHR135C2.970.00148YCK1Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
YCR017C2.970.00151CWH43Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
YPL119C2.830.00233DBP1Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2861
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2041.06E-56SGTC_28799041815 71.4 μMChembridge (Drug-like library)49429710.275362
0.1983.13E-53SGTC_28669034245 58.4 μMChembridge (Drug-like library)64622730.24
0.1062.28E-16SGTC_28609025725 39.0 μMChembridge (Drug-like library)405462480.144578RPP1 & pyrimidine depletion
0.1032.33E-15SGTC_2550chrysin dimethyl ether 71.9 μMMicrosource (Natural product library)888810.128205
0.0912.31E-12SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.21519
0.0841.10E-10SGTC_8221487-0950 154.0 μMChemDiv (Drug-like library)19583750.17284
0.0764.15E-9SGTC_7633453-1109 128.0 μMChemDiv (Drug-like library)15603530.151899
0.0758.38E-9SGTC_28709038528 13.0 μMChembridge (Drug-like library)64633160.186667
0.0732.00E-8SGTC_24355706476 10.6 μMMiscellaneous57253750.0963855
0.0691.23E-7SGTC_12460422-0085 105.0 μMChemDiv (Drug-like library)2642950.138462
0.0681.41E-7SGTC_33429147791 14.5 μMChembridge (Drug-like library)18381680.111111
0.0603.39E-6SGTC_21075363541 170.2 μMChembridge (Fragment library)2440520.208955
0.0603.69E-6SGTC_23097664088 163.9 μMChembridge (Fragment library)7049220.0533333
0.0595.75E-6SGTC_33369143619 71.4 μMChembridge (Drug-like library)455957300.0972222
0.0596.36E-6SGTC_22777947813 106.9 μMChembridge (Fragment library)12467980.178082RSC complex & mRNA processing

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3074911601849.47 μM0.51562517027303Chembridge (Drug-like library)385.887163.6313RNA processing & uracil transport
SGTC_2809796413312.99 μM0.4925371253665Chembridge (Drug-like library)420.332224.4751360S ribosome export
SGTC_3066911724549.47 μM0.49206317176980Chembridge (Drug-like library)371.860583.14413
SGTC_3114912276649.47 μM0.43283617176985Chembridge (Drug-like library)375.8244632.86314
SGTC_3250913558349.47 μM0.426237699353Chembridge (Drug-like library)299.321182.80214
SGTC_2795778001054.55 μM0.421875953673Chembridge (Drug-like library)312.3812434.15113
SGTC_3156909993149.47 μM0.41538518111053Chembridge (Drug-like library)344.835243.85903
SGTC_3285911281820.87 μM0.40845117017947Chembridge (Drug-like library)408.899043.29615cell wall
SGTC_2998906676271.43 μM0.3939394945196Chembridge (Drug-like library)297.348363.54713RPP1 & pyrimidine depletion
SGTC_2914130-127835.5 μM0.3751068044ChemDiv (Drug-like library)375.806223.41505Golgi