9028737

2,4-dimethoxy-N-(2-methylquinolin-5-yl)benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2863
Screen concentration 58.4 μM
Source Chembridge (Drug-like library)
PubChem CID 6460917
SMILES CC1=NC2=C(C=C1)C(=CC=C2)NC(=O)C3=C(C=C(C=C3)OC)OC
Standardized SMILES COc1ccc(C(=O)Nc2cccc3nc(C)ccc23)c(OC)c1
Molecular weight 322.3578
ALogP 3.05
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.42
% growth inhibition (Hom. pool) 7.37


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6460917
Download HIP data (tab-delimited text)  (excel)
Gene:BRL1(YHR036W)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.5||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:NIP7(YPL211W)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.5||SGD DESC:Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p Gene:NUF2(YOL069W)|FD-Score:3.82|P-value:6.66E-5|Clearance:0.5||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:BRL1(YHR036W)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.5||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:NIP7(YPL211W)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.5||SGD DESC:Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p Gene:NUF2(YOL069W)|FD-Score:3.82|P-value:6.66E-5|Clearance:0.5||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6460917
Download HOP data (tab-delimited text)  (excel)
Gene:ATP14(YLR295C)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:BRO1(YPL084W)|FD-Score:3.78|P-value:7.93E-5||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:COG6(YNL041C)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAL7(YIR031C)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DBP3(YGL078C)|FD-Score:-4.23|P-value:1.16E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EEB1(YPL095C)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication Gene:EMP70(YLR083C)|FD-Score:-3.41|P-value:3.23E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:GEA1(YJR031C)|FD-Score:3.35|P-value:4.06E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GOT1(YMR292W)|FD-Score:3.9|P-value:4.88E-5||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:ICP55(YER078C)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:IKI3(YLR384C)|FD-Score:3.13|P-value:8.69E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:MHF2(YDL160C-A)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRP4(YHL004W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTG1(YMR097C)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:PRO2(YOR323C)|FD-Score:3.86|P-value:5.59E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PSR2(YLR019W)|FD-Score:-3.94|P-value:4.13E-5||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:ROY1(YMR258C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p Gene:SKI7(YOR076C)|FD-Score:3.27|P-value:5.43E-4||SGD DESC:Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype Gene:SNT309(YPR101W)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SOH1(YGL127C)|FD-Score:4.41|P-value:5.22E-6||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SPR6(YER115C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SRL1(YOR247W)|FD-Score:-3.87|P-value:5.48E-5||SGD DESC:Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication Gene:STD1(YOR047C)|FD-Score:4.43|P-value:4.81E-6||SGD DESC:Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] Gene:TDA9(YML081W)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TRP3(YKL211C)|FD-Score:-6.15|P-value:3.99E-10||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:UBP12(YJL197W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm Gene:VPS52(YDR484W)|FD-Score:-4.16|P-value:1.57E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YCL023C(YCL023C_d)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Gene:YDL119C(YDL119C_p)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria Gene:YML034C-A(YML034C-A_d)|FD-Score:4.03|P-value:2.82E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR105W-A(YMR105W-A_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function Gene:YNL324W(YNL324W_d)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR063W(YNR063W_p)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Putative zinc-cluster protein of unknown function Gene:ATP14(YLR295C)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:BRO1(YPL084W)|FD-Score:3.78|P-value:7.93E-5||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:COG6(YNL041C)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAL7(YIR031C)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DBP3(YGL078C)|FD-Score:-4.23|P-value:1.16E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EEB1(YPL095C)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication Gene:EMP70(YLR083C)|FD-Score:-3.41|P-value:3.23E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:GEA1(YJR031C)|FD-Score:3.35|P-value:4.06E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GOT1(YMR292W)|FD-Score:3.9|P-value:4.88E-5||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:ICP55(YER078C)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:IKI3(YLR384C)|FD-Score:3.13|P-value:8.69E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:MHF2(YDL160C-A)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRP4(YHL004W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTG1(YMR097C)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:PRO2(YOR323C)|FD-Score:3.86|P-value:5.59E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PSR2(YLR019W)|FD-Score:-3.94|P-value:4.13E-5||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:ROY1(YMR258C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p Gene:SKI7(YOR076C)|FD-Score:3.27|P-value:5.43E-4||SGD DESC:Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype Gene:SNT309(YPR101W)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SOH1(YGL127C)|FD-Score:4.41|P-value:5.22E-6||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SPR6(YER115C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SRL1(YOR247W)|FD-Score:-3.87|P-value:5.48E-5||SGD DESC:Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication Gene:STD1(YOR047C)|FD-Score:4.43|P-value:4.81E-6||SGD DESC:Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] Gene:TDA9(YML081W)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TRP3(YKL211C)|FD-Score:-6.15|P-value:3.99E-10||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:UBP12(YJL197W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm Gene:VPS52(YDR484W)|FD-Score:-4.16|P-value:1.57E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YCL023C(YCL023C_d)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Gene:YDL119C(YDL119C_p)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria Gene:YML034C-A(YML034C-A_d)|FD-Score:4.03|P-value:2.82E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR105W-A(YMR105W-A_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function Gene:YNL324W(YNL324W_d)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR063W(YNR063W_p)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Putative zinc-cluster protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL069W3.826.66E-50.50NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YPL211W3.768.61E-50.50NIP7Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YHR036W3.433.03E-40.50BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YIL091C2.930.001690.15UTP25Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
YER104W2.780.002740.04RTT105Protein with a role in regulation of Ty1 transposition
YJR017C2.740.003070.12ESS1Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
YBR140C2.620.004360.04IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YOR060C2.580.004950.01SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YLR100W2.570.005080.25ERG273-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YKL083W_d2.320.010100.02YKL083W_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
YDR180W2.300.010800.01SCC2Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
YAL032C2.290.010900.00PRP45Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
YNL103W2.290.011000.04MET4Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YPR094W2.250.012200.01RDS3Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
YDR041W2.240.012500.02RSM10Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL095C4.731.14E-6EEB1Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
YOR047C4.434.81E-6STD1Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
YGL127C4.415.22E-6SOH1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
YML034C-A_d4.032.82E-5YML034C-A_dDubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR292W3.904.88E-5GOT1Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
YOR323C3.865.59E-5PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YPL084W3.787.93E-5BRO1Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YDL119C_p3.729.87E-5YDL119C_pPutative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YMR105W-A_p3.691.11E-4YMR105W-A_pPutative protein of unknown function
YIR031C3.641.34E-4DAL7Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDL160C-A3.532.05E-4MHF2Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
YHL004W3.502.29E-4MRP4Mitochondrial ribosomal protein of the small subunit
YER115C3.502.33E-4SPR6Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
YPR101W3.403.37E-4SNT309Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YJL197W3.403.38E-4UBP12Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm

GO enrichment analysis for SGTC_2863
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1102.98E-17SGTC_31769106582 49.5 μMChembridge (Drug-like library)170180270.296875
0.0912.31E-12SGTC_28619024595 19.5 μMChembridge (Drug-like library)164828100.21519
0.0881.35E-11SGTC_31009120536 49.5 μMChembridge (Drug-like library)164211960.0722892
0.0809.12E-10SGTC_8650488-0499 301.0 μMChemDiv (Drug-like library)96346510.0857143
0.0772.69E-9SGTC_28669034245 58.4 μMChembridge (Drug-like library)64622730.611111
0.0772.94E-9SGTC_1609st001574 46.4 μMTimTec (Natural product derivative library)39600120.0744681
0.0765.11E-9SGTC_28629027634 71.4 μMChembridge (Drug-like library)50125620.164557ERG2
0.0757.95E-9SGTC_28799041815 71.4 μMChembridge (Drug-like library)49429710.242424
0.0722.50E-8SGTC_9781416-0512 87.4 μMChemDiv (Drug-like library)68140030.268657redox potentiating
0.0722.79E-8SGTC_31119122088 49.5 μMChembridge (Drug-like library)168767040.139241
0.0723.00E-8SGTC_1973st070275 50.2 μMTimTec (Natural product derivative library)171183340.12
0.0723.43E-8SGTC_6604031-1742 102.0 μMChemDiv (Drug-like library)67387060.1625redox potentiating
0.0706.33E-8SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.150685
0.0672.13E-7SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.126582
0.0647.18E-7SGTC_32629137218 49.5 μMChembridge (Drug-like library)176506640.15942

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2866903424558.44 μM0.6111116462273Chembridge (Drug-like library)331.195984.41212
SGTC_2904722513542.03 μM0.43754446116Chembridge (Drug-like library)364.437564.06914
SGTC_3195911308249.47 μM0.40350917018038Chembridge (Drug-like library)301.337063.05114
SGTC_1759st04305970 μM0.38983669426TimTec (Natural product derivative library)285.29462.45314amide catabolism
SGTC_3192911036249.47 μM0.38235316649480Chembridge (Drug-like library)358.393223.83914mitochondrial processes
SGTC_1090132-003633.7 μM0.37288167274ChemDiv (Drug-like library)293.31663.26423
SGTC_9383126-1755342 μM0.3728811777771ChemDiv (Drug-like library)390.388723.01235
SGTC_22817943571200 μM0.3666671244024Chembridge (Fragment library)231.247222.47913
SGTC_3205911348349.47 μM0.36666717018033Chembridge (Drug-like library)271.311083.06813
SGTC_8261683-5028118 μM0.355932722377ChemDiv (Drug-like library)261.703583.26212