Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR116C | 5.38 | 3.63E-8 | 1.28 | RPO31 | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
YLR153C | 4.11 | 2.01E-5 | 1.00 | ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions |
YDL145C | 3.10 | 9.60E-4 | 0.16 | COP1 | Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway |
YAR007C | 2.94 | 0.00163 | 0.02 | RFA1 | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
YOR048C | 2.92 | 0.00174 | 0.01 | RAT1 | Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination |
YMR268C | 2.91 | 0.00181 | 0.00 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YLR222C | 2.91 | 0.00182 | 0.12 | UTP13 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YDR113C | 2.78 | 0.00268 | 0.08 | PDS1 | Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation |
YLR106C | 2.70 | 0.00346 | 0.02 | MDN1 | Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus |
YGR245C | 2.68 | 0.00370 | 0.01 | SDA1 | Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis |
YPL160W | 2.66 | 0.00386 | 0.12 | CDC60 | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
YDL097C | 2.55 | 0.00546 | 0.06 | RPN6 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress |
YLR088W | 2.49 | 0.00647 | 0.02 | GAA1 | Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER |
YMR211W | 2.47 | 0.00684 | 0.02 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YHR007C | 2.44 | 0.00730 | 0.00 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |