Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR260C | 3.90 | 4.79E-5 | 0.23 | TIF11 | Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 |
YGR060W | 3.72 | 1.01E-4 | 0.23 | ERG25 | C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol |
YDL103C | 3.63 | 1.44E-4 | 0.23 | QRI1 | UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress |
YGL097W | 3.50 | 2.34E-4 | 0.23 | SRM1 | Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p |
YNL002C | 3.28 | 5.24E-4 | 0.23 | RLP7 | Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs |
YPL082C | 3.05 | 0.00115 | 0.00 | MOT1 | Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA |
YOR260W | 3.05 | 0.00115 | 0.00 | GCD1 | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YER104W | 3.05 | 0.00116 | 0.08 | RTT105 | Protein with a role in regulation of Ty1 transposition |
YMR281W | 2.97 | 0.00151 | 0.00 | GPI12 | ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp |
YKL088W | 2.96 | 0.00152 | 0.01 | CAB3 | Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC |
YGL171W | 2.96 | 0.00155 | 0.07 | ROK1 | RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation |
YOR218C_d | 2.89 | 0.00193 | 0.04 | YOR218C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W |
YOR257W | 2.84 | 0.00222 | 0.03 | CDC31 | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
YLR078C | 2.81 | 0.00246 | 0.10 | BOS1 | v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi |
YKL059C | 2.71 | 0.00336 | 0.01 | MPE1 | Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif |