9041815

2-chloro-N-(4-propoxyphenyl)benzamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2879
Screen concentration 71.4 μM
Source Chembridge (Drug-like library)
PubChem CID 4942971
SMILES CCCOC1=CC=C(C=C1)NC(=O)C2=CC=CC=C2Cl
Standardized SMILES CCCOc1ccc(NC(=O)c2ccccc2Cl)cc1
Molecular weight 289.7567
ALogP 4.14
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.39
% growth inhibition (Hom. pool) 6.49


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4942971
Download HIP data (tab-delimited text)  (excel)
Gene:RET3(YPL010W)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.34||SGD DESC:Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER Gene:RPC19(YNL113W)|FD-Score:-3.34|P-value:4.18E-4|Clearance:0||SGD DESC:RNA polymerase subunit AC19, common to RNA polymerases I and III Gene:RPT3(YDR394W)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B Gene:RRP45(YDR280W)|FD-Score:3.6|P-value:1.57E-4|Clearance:0.34||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:SEC62(YPL094C)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.34||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:RET3(YPL010W)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.34||SGD DESC:Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER Gene:RPC19(YNL113W)|FD-Score:-3.34|P-value:4.18E-4|Clearance:0||SGD DESC:RNA polymerase subunit AC19, common to RNA polymerases I and III Gene:RPT3(YDR394W)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B Gene:RRP45(YDR280W)|FD-Score:3.6|P-value:1.57E-4|Clearance:0.34||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:SEC62(YPL094C)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.34||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4942971
Download HOP data (tab-delimited text)  (excel)
Gene:ALG8(YOR067C)|FD-Score:-4.22|P-value:1.24E-5||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:DAP2(YHR028C)|FD-Score:-4.38|P-value:5.98E-6||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DBP3(YGL078C)|FD-Score:-4.24|P-value:1.14E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:ESC8(YOL017W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication Gene:GCN2(YDR283C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:LOS1(YKL205W)|FD-Score:-3.35|P-value:4.06E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MSM1(YGR171C)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p Gene:PHO86(YJL117W)|FD-Score:-3.24|P-value:6.06E-4||SGD DESC:Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress Gene:PKH3(YDR466W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:RRM3(YHR031C)|FD-Score:-3.36|P-value:3.96E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:SNF7(YLR025W)|FD-Score:-4.94|P-value:3.89E-7||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Gene:SPG1(YGR236C)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:THI73(YLR004C)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs Gene:TRP2(YER090W)|FD-Score:-3.8|P-value:7.20E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VPS52(YDR484W)|FD-Score:-3.52|P-value:2.20E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBR051W(YBR051W_d)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YGK3(YOL128C)|FD-Score:-4.01|P-value:3.01E-5||SGD DESC:Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation Gene:YGR054W(YGR054W)|FD-Score:3.2|P-value:6.91E-4||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YIR021W-A(YIR021W-A_p)|FD-Score:3.09|P-value:9.96E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL160C(YJL160C_p)|FD-Score:-3.4|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YML122C(YML122C_d)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL140C(YNL140C_p)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C Gene:YNL143C(YNL143C_p)|FD-Score:-4.55|P-value:2.68E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:ALG8(YOR067C)|FD-Score:-4.22|P-value:1.24E-5||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:DAP2(YHR028C)|FD-Score:-4.38|P-value:5.98E-6||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DBP3(YGL078C)|FD-Score:-4.24|P-value:1.14E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:ESC8(YOL017W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication Gene:GCN2(YDR283C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:LOS1(YKL205W)|FD-Score:-3.35|P-value:4.06E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MSM1(YGR171C)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p Gene:PHO86(YJL117W)|FD-Score:-3.24|P-value:6.06E-4||SGD DESC:Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress Gene:PKH3(YDR466W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:RRM3(YHR031C)|FD-Score:-3.36|P-value:3.96E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:SNF7(YLR025W)|FD-Score:-4.94|P-value:3.89E-7||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Gene:SPG1(YGR236C)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:THI73(YLR004C)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs Gene:TRP2(YER090W)|FD-Score:-3.8|P-value:7.20E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VPS52(YDR484W)|FD-Score:-3.52|P-value:2.20E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBR051W(YBR051W_d)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YGK3(YOL128C)|FD-Score:-4.01|P-value:3.01E-5||SGD DESC:Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation Gene:YGR054W(YGR054W)|FD-Score:3.2|P-value:6.91E-4||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YIR021W-A(YIR021W-A_p)|FD-Score:3.09|P-value:9.96E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL160C(YJL160C_p)|FD-Score:-3.4|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YML122C(YML122C_d)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL140C(YNL140C_p)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C Gene:YNL143C(YNL143C_p)|FD-Score:-4.55|P-value:2.68E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR280W3.601.57E-40.34RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YPL010W3.334.28E-40.34RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YPL094C3.275.41E-40.34SEC62Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDR308C2.930.001700.01SRB7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YHR188C2.920.001740.18GPI16Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
YOL038W2.740.003040.03PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YMR270C2.710.003330.25RRN9Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YPL142C_d2.460.006940.06YPL142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YDR243C2.400.008250.04PRP28RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YER112W2.350.009280.04LSM4Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
YJR065C2.310.010400.01ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YDR246W2.300.010600.07TRS23One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
YPL117C2.230.012800.02IDI1Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YOL102C2.220.013300.01TPT1tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
YNL172W2.210.013500.00APC1Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR171C4.052.54E-5MSM1Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
YNL140C_p3.729.99E-5YNL140C_pProtein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
YOL017W3.452.85E-4ESC8Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
YBR051W_d3.373.76E-4YBR051W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YDR283C3.275.34E-4GCN2Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
YML122C_d3.255.86E-4YML122C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR054W3.206.91E-4YGR054WEukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YLR004C3.148.48E-4THI73Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YIR021W-A_p3.099.96E-4YIR021W-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YOR076C3.080.00103SKI7Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
YBR009C3.010.00130HHF1Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YNL045W2.980.00143LAP2Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR403W2.930.00168DIT1Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YOL052C-A2.900.00185DDR2Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
YLL051C2.900.00187FRE6Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels

GO enrichment analysis for SGTC_2879
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2041.06E-56SGTC_28619024595 19.5 μMChembridge (Drug-like library)164828100.275362
0.1524.78E-32SGTC_28669034245 58.4 μMChembridge (Drug-like library)64622730.274194
0.0905.19E-12SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.22807
0.0822.66E-10SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.140845
0.0807.57E-10SGTC_2547epiafzelechin trimethyl ether 100.0 μMMicrosource (Natural product library)67086300.102941
0.0782.39E-9SGTC_680986-0284 82.8 μMChemDiv (Drug-like library)4232780.147541
0.0757.95E-9SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.242424
0.0759.55E-9SGTC_2615-fluorouridine 15.4 μMMiscellaneous18210.0571429exosome
0.0732.15E-8SGTC_9031134-0042 114.0 μMChemDiv (Drug-like library)7010090.185185
0.0722.99E-8SGTC_33379144342 33.5 μMChembridge (Drug-like library)176829490.227273
0.0708.66E-8SGTC_28709038528 13.0 μMChembridge (Drug-like library)64633160.171875
0.0631.39E-6SGTC_31199125183 49.5 μMChembridge (Drug-like library)226953340.0923077
0.0612.42E-6SGTC_2425hr heat shock (37°C) + 5-fluorouracil 4.6 μMMiscellaneous33850.0566038heat shock/prefoldin
0.0612.33E-6SGTC_1859st055998 20.0 μMTimTec (Natural product derivative library)6763010.0895522
0.0612.62E-6SGTC_1524469-0003 551.2 μMChemDiv (Drug-like library)6972800.131148

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3173910569349.47 μM0.7517096658Chembridge (Drug-like library)289.756744.13512
SGTC_3194911190349.47 μM0.54166717087251Chembridge (Drug-like library)303.740263.71313
SGTC_2864903475547.6 μM0.4814814930451Chembridge (Drug-like library)361.393862.58124
SGTC_3290912103171.43 μM0.44067817014854Chembridge (Drug-like library)354.3781634.00915
SGTC_12961068-010211.9 μM0.431373767053ChemDiv (Drug-like library)310.175224.02712
SGTC_2980901434225.29 μM0.4313732996599Chembridge (Drug-like library)347.363983.94214
SGTC_1270180-033359.13 μM0.423077771601ChemDiv (Drug-like library)324.158743.71113mitochondrial response to ROS
SGTC_3206911435049.47 μM0.40384617087243Chembridge (Drug-like library)283.321783.53513
SGTC_1300136-0219337.66 μM0.4234244ChemDiv (Drug-like library)296.148643.77812
SGTC_3278913960549.47 μM0.47958859Chembridge (Drug-like library)267.6585263.6913