9058944

N-(4-methoxyphenyl)-2-(4-methylphenoxy)butanamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2886
Screen concentration 52.0 μM
Source Chembridge (Drug-like library)
PubChem CID 4949929
SMILES CCC(C(=O)NC1=CC=C(C=C1)OC)OC2=CC=C(C=C2)C
Standardized SMILES CCC(Oc1ccc(C)cc1)C(=O)Nc2ccc(OC)cc2
Molecular weight 299.3642
ALogP 3.93
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.26
% growth inhibition (Hom. pool) 3.21


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4949929
Download HIP data (tab-delimited text)  (excel)
Gene:EBP2(YKL172W)|FD-Score:-3.29|P-value:5.03E-4|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:RPB2(YOR151C)|FD-Score:-3.37|P-value:3.78E-4|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit Gene:SHR3(YDL212W)|FD-Score:-3.58|P-value:1.70E-4|Clearance:0||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:UFD1(YGR048W)|FD-Score:-3.48|P-value:2.54E-4|Clearance:0||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) Gene:EBP2(YKL172W)|FD-Score:-3.29|P-value:5.03E-4|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:RPB2(YOR151C)|FD-Score:-3.37|P-value:3.78E-4|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit Gene:SHR3(YDL212W)|FD-Score:-3.58|P-value:1.70E-4|Clearance:0||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:UFD1(YGR048W)|FD-Score:-3.48|P-value:2.54E-4|Clearance:0||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4949929
Download HOP data (tab-delimited text)  (excel)
Gene:ATP23(YNR020C)|FD-Score:-3.63|P-value:1.41E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:ECM29(YHL030W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:GFD1(YMR255W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GIM4(YEL003W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GLT1(YDL171C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source Gene:GSF2(YML048W)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HAP4(YKL109W)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex Gene:LOA1(YPR139C)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:PEX29(YDR479C)|FD-Score:-3.11|P-value:9.20E-4||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PUS4(YNL292W)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) Gene:RAD33(YML011C)|FD-Score:-3.36|P-value:3.90E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:RIM4(YHL024W)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:SER3(YER081W)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:UBP15(YMR304W)|FD-Score:-3.22|P-value:6.43E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:VPS52(YDR484W)|FD-Score:-4.48|P-value:3.70E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YGL177W(YGL177W_d)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Putative protein of unknown function Gene:YNL277W-A(YNL277W-A_p)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Putative protein of unknown function Gene:ATP23(YNR020C)|FD-Score:-3.63|P-value:1.41E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:ECM29(YHL030W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:GFD1(YMR255W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GIM4(YEL003W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GLT1(YDL171C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source Gene:GSF2(YML048W)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HAP4(YKL109W)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex Gene:LOA1(YPR139C)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:PEX29(YDR479C)|FD-Score:-3.11|P-value:9.20E-4||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PUS4(YNL292W)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) Gene:RAD33(YML011C)|FD-Score:-3.36|P-value:3.90E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:RIM4(YHL024W)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:SER3(YER081W)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:UBP15(YMR304W)|FD-Score:-3.22|P-value:6.43E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:VPS52(YDR484W)|FD-Score:-4.48|P-value:3.70E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YGL177W(YGL177W_d)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Putative protein of unknown function Gene:YNL277W-A(YNL277W-A_p)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YIR012W2.860.002090.20SQT1Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YHR197W2.660.003920.08RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YER133W2.580.004950.12GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YHR036W2.460.007010.02BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YGL099W2.440.007320.02LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YNL181W_p2.420.007790.02YNL181W_pPutative oxidoreductase; required for cell viability
YOR146W_d2.400.008270.04YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YIL051C2.360.009180.07MMF1Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YKL013C2.290.011000.02ARC19Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YGR267C2.270.011700.01FOL2GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YBR167C2.260.011900.08POP7Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YLR397C2.180.014600.02AFG2ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
YKL012W2.160.015500.03PRP40U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YGR156W2.120.016900.11PTI1Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YJL203W2.020.021900.01PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YEL003W3.711.04E-4GIM4Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YDL171C3.691.13E-4GLT1NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YNL292W3.671.21E-4PUS4Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YER081W3.442.86E-4SER33-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
YKL109W3.334.28E-4HAP4Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YMR175W-A_p3.265.63E-4YMR175W-A_pPutative protein of unknown function
YHL030W3.236.11E-4ECM29Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
YNL277W-A_p3.197.23E-4YNL277W-A_pPutative protein of unknown function
YMR255W3.187.32E-4GFD1Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress
YGR093W_p3.177.61E-4YGR093W_pPutative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YLR290C_p3.030.00120YLR290C_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
YPL232W3.030.00121SSO1Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
YKR023W_p2.900.00189YKR023W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR006C2.900.00189PLB2Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YER175W-A_p2.870.00202YER175W-A_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

GO enrichment analysis for SGTC_2886
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2129.84E-61SGTC_28999053889 58.4 μMChembridge (Drug-like library)64700520.215385
0.1882.56E-48SGTC_28919063876 19.5 μMChembridge (Drug-like library)64724780.173913
0.1631.87E-36SGTC_28989056270 58.4 μMChembridge (Drug-like library)191546990.102564
0.0855.84E-11SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.16
0.0807.60E-10SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.129032
0.0757.69E-9SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.0895522
0.0723.13E-8SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.15
0.0707.88E-8SGTC_12201838-0075 193.0 μMChemDiv (Drug-like library)55296450.15942
0.0699.40E-8SGTC_1570verbenone 133.0 μMTimTec (Pure natural product library)290250.0925926
0.0681.71E-7SGTC_21765809774 34.0 μMChembridge (Fragment library)28705390.0847458mitochondrial processes
0.0673.13E-7SGTC_9681309-0633 340.0 μMChemDiv (Drug-like library)37619760.202899
0.0663.74E-7SGTC_14444112-3581 28.0 μMChemDiv (Drug-like library)28772490.1
0.0621.55E-6SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.111111
0.0621.78E-6SGTC_33149135860 59.4 μMChembridge (Drug-like library)252524780.114286
0.0621.97E-6SGTC_9391165-0479 45.3 μMChemDiv (Drug-like library)13773470.12963

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2793732513181.82 μM0.4313734176441Chembridge (Drug-like library)287.3287234.08213
SGTC_2882905804458.44 μM0.42307718076804Chembridge (Drug-like library)273.3021433.62513
SGTC_2794778538227.27 μM0.4107142205081Chembridge (Drug-like library)396.45953.57225
SGTC_2877904072471.43 μM0.4038466463895Chembridge (Drug-like library)285.337663.30813
SGTC_13621611-0397101 μM0.39130427816ChemDiv (Drug-like library)227.258523.65612
SGTC_8730591-4978488 μM0.3888893305145ChemDiv (Drug-like library)300.309242.50815
SGTC_3085911737649.47 μM0.38333316480349Chembridge (Drug-like library)331.3382233.44915
SGTC_2894904862532.47 μM0.370374092861Chembridge (Drug-like library)278.346781.38214
SGTC_2984902210938.96 μM0.370376459207Chembridge (Drug-like library)269.338263.57512
SGTC_5414513-132194 μM0.36747515ChemDiv (Drug-like library)305.391963.51314