Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL106W | 8.62 | 3.36E-18 | AAT1 | Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis |
YLR012C_p | 5.07 | 1.95E-7 | YLR012C_p | Putative protein of unknown function; YLR012C is not an essential gene |
YPR100W | 4.22 | 1.21E-5 | MRPL51 | Mitochondrial ribosomal protein of the large subunit |
YJL182C_d | 4.22 | 1.22E-5 | YJL182C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W |
YJL183W | 3.92 | 4.42E-5 | MNN11 | Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p |
YHR025W | 3.84 | 6.21E-5 | THR1 | Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway |
YOR019W | 3.77 | 8.02E-5 | YOR019W | Protein of unknown function that may interact with ribosomes, based on co-purification experiments |
YML013W | 3.76 | 8.34E-5 | UBX2 | Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis |
YOR144C | 3.67 | 1.20E-4 | ELG1 | Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication |
YHL029C_p | 3.67 | 1.24E-4 | OCA5_p | Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YNL224C | 3.55 | 1.90E-4 | SQS1 | Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress |
YBR210W | 3.54 | 2.00E-4 | ERV15 | Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication |
YCR032W | 3.52 | 2.17E-4 | BPH1 | Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting |
YKL207W | 3.43 | 3.07E-4 | EMC3 | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111 |
YHR011W | 3.40 | 3.31E-4 | DIA4 | Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth |