9058547

N-(2-phenylethyl)-4-prop-2-ynoxybenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2888
Screen concentration 13.0 μM
Source Chembridge (Drug-like library)
PubChem CID 16476514
SMILES C#CCOC1=CC=C(C=C1)C(=O)NCCC2=CC=CC=C2
Standardized SMILES O=C(NCCc1ccccc1)c2ccc(OCC#C)cc2
Molecular weight 279.3331
ALogP 4.12
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.13
% growth inhibition (Hom. pool) 4.29


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16476514
Download HIP data (tab-delimited text)  (excel)
Gene:ARC35(YNR035C)|FD-Score:5.06|P-value:2.13E-7|Clearance:1.66||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:CDC60(YPL160W)|FD-Score:3.4|P-value:3.39E-4|Clearance:0.03||SGD DESC:Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA Gene:CIA2(YHR122W)|FD-Score:-6.84|P-value:3.97E-12|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:DYS1(YHR068W)|FD-Score:3.19|P-value:7.14E-4|Clearance:0.09||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:ERD2(YBL040C)|FD-Score:-3.12|P-value:9.14E-4|Clearance:0||SGD DESC:HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins Gene:LCP5(YER127W)|FD-Score:-3.14|P-value:8.42E-4|Clearance:0||SGD DESC:Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus Gene:POP3(YNL282W)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.18||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:UFD1(YGR048W)|FD-Score:-3.15|P-value:8.03E-4|Clearance:0||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) Gene:YCR013C(YCR013C_d)|FD-Score:-4.77|P-value:9.25E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant Gene:YKL036C(YKL036C_d)|FD-Score:3.1|P-value:9.63E-4|Clearance:0.02||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Gene:YLR140W(YLR140W_d)|FD-Score:-3.6|P-value:1.58E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YOR218C(YOR218C_d)|FD-Score:-4.72|P-value:1.17E-6|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W Gene:ARC35(YNR035C)|FD-Score:5.06|P-value:2.13E-7|Clearance:1.66||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:CDC60(YPL160W)|FD-Score:3.4|P-value:3.39E-4|Clearance:0.03||SGD DESC:Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA Gene:CIA2(YHR122W)|FD-Score:-6.84|P-value:3.97E-12|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:DYS1(YHR068W)|FD-Score:3.19|P-value:7.14E-4|Clearance:0.09||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:ERD2(YBL040C)|FD-Score:-3.12|P-value:9.14E-4|Clearance:0||SGD DESC:HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins Gene:LCP5(YER127W)|FD-Score:-3.14|P-value:8.42E-4|Clearance:0||SGD DESC:Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus Gene:POP3(YNL282W)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.18||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:UFD1(YGR048W)|FD-Score:-3.15|P-value:8.03E-4|Clearance:0||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) Gene:YCR013C(YCR013C_d)|FD-Score:-4.77|P-value:9.25E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant Gene:YKL036C(YKL036C_d)|FD-Score:3.1|P-value:9.63E-4|Clearance:0.02||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Gene:YLR140W(YLR140W_d)|FD-Score:-3.6|P-value:1.58E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YOR218C(YOR218C_d)|FD-Score:-4.72|P-value:1.17E-6|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16476514
Download HOP data (tab-delimited text)  (excel)
Gene:AAT1(YKL106W)|FD-Score:8.62|P-value:3.36E-18||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ABM1(YJR108W)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Protein of unknown function, required for normal microtubule organization Gene:AGP1(YCL025C)|FD-Score:3.25|P-value:5.70E-4||SGD DESC:Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication Gene:AIM41(YOR215C)|FD-Score:-3.88|P-value:5.31E-5||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:APN1(YKL114C)|FD-Score:3.28|P-value:5.11E-4||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:ATH1(YPR026W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Acid trehalase required for utilization of extracellular trehalose Gene:BER1(YLR412W)|FD-Score:-3.45|P-value:2.83E-4||SGD DESC:Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene Gene:BPH1(YCR032W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting Gene:CHK1(YBR274W)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase Gene:CPD1(YGR247W)|FD-Score:-3.87|P-value:5.44E-5||SGD DESC:Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress Gene:CRH1(YGR189C)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Gene:DEG1(YFL001W)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability Gene:DIA4(YHR011W)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Gene:DSE1(YER124C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ELG1(YOR144C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:EMC3(YKL207W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111 Gene:EPS1(YIL005W)|FD-Score:-4.07|P-value:2.40E-5||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:ERV15(YBR210W)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication Gene:FAR8(YMR029C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p Gene:FLC3(YGL139W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER Gene:IMA5(YJL216C)|FD-Score:-3.46|P-value:2.67E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:INO4(YOL108C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:IRC5(YFR038W)|FD-Score:3.19|P-value:7.09E-4||SGD DESC:Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci Gene:JIP3(YLR331C_d)|FD-Score:-4.36|P-value:6.41E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:MDL1(YLR188W)|FD-Score:-3.31|P-value:4.62E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress Gene:MNN11(YJL183W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MRPL51(YPR100W)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSW1(YDR268W)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:OCA5(YHL029C_p)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:OCA6(YDR067C_p)|FD-Score:-3.63|P-value:1.39E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT Gene:PHO87(YCR037C)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:POP2(YNR052C)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRS5(YOL061W)|FD-Score:-3.83|P-value:6.44E-5||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress Gene:PTC7(YHR076W)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope Gene:PUT1(YLR142W)|FD-Score:-3.16|P-value:7.82E-4||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RTC6(YPL183W-A)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SKI3(YPR189W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SKI8(YGL213C)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype Gene:SPG4(YMR107W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SQS1(YNL224C)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:STI1(YOR027W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:SYO1(YDL063C)|FD-Score:-3.26|P-value:5.67E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:THR1(YHR025W)|FD-Score:3.84|P-value:6.21E-5||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TIS11(YLR136C)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:TRP3(YKL211C)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSC3(YBR058C-A)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX2(YML013W)|FD-Score:3.76|P-value:8.34E-5||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:UFD2(YDL190C)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 Gene:VAM3(YOR106W)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:YAL065C(YAL065C_p)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAP5(YIR018W)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YDL032W(YDL032W_d)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YDL094C(YDL094C_d)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Gene:YEL010W(YEL010W_d)|FD-Score:3.22|P-value:6.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFR039C(YFR039C_p)|FD-Score:-3.92|P-value:4.43E-5||SGD DESC:Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces Gene:YGL118C(YGL118C_d)|FD-Score:-3.14|P-value:8.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL138C(YGL138C_p)|FD-Score:-5.19|P-value:1.08E-7||SGD DESC:Putative protein of unknown function; has no significant sequence similarity to any known protein Gene:YJL132W(YJL132W_p)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YJL182C(YJL182C_d)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Gene:YJR115W(YJR115W_p)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YLR012C(YLR012C_p)|FD-Score:5.07|P-value:1.95E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR211C(YLR211C_p)|FD-Score:-3.09|P-value:9.95E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YLR294C(YLR294C_d)|FD-Score:-4.86|P-value:5.93E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YOR019W(YOR019W)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YPL107W(YPL107W_p)|FD-Score:-3.76|P-value:8.60E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene Gene:AAT1(YKL106W)|FD-Score:8.62|P-value:3.36E-18||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ABM1(YJR108W)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Protein of unknown function, required for normal microtubule organization Gene:AGP1(YCL025C)|FD-Score:3.25|P-value:5.70E-4||SGD DESC:Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication Gene:AIM41(YOR215C)|FD-Score:-3.88|P-value:5.31E-5||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:APN1(YKL114C)|FD-Score:3.28|P-value:5.11E-4||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:ATH1(YPR026W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Acid trehalase required for utilization of extracellular trehalose Gene:BER1(YLR412W)|FD-Score:-3.45|P-value:2.83E-4||SGD DESC:Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene Gene:BPH1(YCR032W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting Gene:CHK1(YBR274W)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase Gene:CPD1(YGR247W)|FD-Score:-3.87|P-value:5.44E-5||SGD DESC:Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress Gene:CRH1(YGR189C)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Gene:DEG1(YFL001W)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability Gene:DIA4(YHR011W)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Gene:DSE1(YER124C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ELG1(YOR144C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:EMC3(YKL207W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111 Gene:EPS1(YIL005W)|FD-Score:-4.07|P-value:2.40E-5||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:ERV15(YBR210W)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication Gene:FAR8(YMR029C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p Gene:FLC3(YGL139W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER Gene:IMA5(YJL216C)|FD-Score:-3.46|P-value:2.67E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:INO4(YOL108C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:IRC5(YFR038W)|FD-Score:3.19|P-value:7.09E-4||SGD DESC:Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci Gene:JIP3(YLR331C_d)|FD-Score:-4.36|P-value:6.41E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:MDL1(YLR188W)|FD-Score:-3.31|P-value:4.62E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress Gene:MNN11(YJL183W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MRPL51(YPR100W)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSW1(YDR268W)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:OCA5(YHL029C_p)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:OCA6(YDR067C_p)|FD-Score:-3.63|P-value:1.39E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT Gene:PHO87(YCR037C)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:POP2(YNR052C)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRS5(YOL061W)|FD-Score:-3.83|P-value:6.44E-5||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress Gene:PTC7(YHR076W)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope Gene:PUT1(YLR142W)|FD-Score:-3.16|P-value:7.82E-4||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RTC6(YPL183W-A)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SKI3(YPR189W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SKI8(YGL213C)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype Gene:SPG4(YMR107W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SQS1(YNL224C)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:STI1(YOR027W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:SYO1(YDL063C)|FD-Score:-3.26|P-value:5.67E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:THR1(YHR025W)|FD-Score:3.84|P-value:6.21E-5||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TIS11(YLR136C)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:TRP3(YKL211C)|FD-Score:-4.12|P-value:1.93E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSC3(YBR058C-A)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:UBX2(YML013W)|FD-Score:3.76|P-value:8.34E-5||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:UFD2(YDL190C)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 Gene:VAM3(YOR106W)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:YAL065C(YAL065C_p)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAP5(YIR018W)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YDL032W(YDL032W_d)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YDL094C(YDL094C_d)|FD-Score:-3.1|P-value:9.54E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Gene:YEL010W(YEL010W_d)|FD-Score:3.22|P-value:6.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFR039C(YFR039C_p)|FD-Score:-3.92|P-value:4.43E-5||SGD DESC:Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces Gene:YGL118C(YGL118C_d)|FD-Score:-3.14|P-value:8.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL138C(YGL138C_p)|FD-Score:-5.19|P-value:1.08E-7||SGD DESC:Putative protein of unknown function; has no significant sequence similarity to any known protein Gene:YJL132W(YJL132W_p)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YJL182C(YJL182C_d)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Gene:YJR115W(YJR115W_p)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YLR012C(YLR012C_p)|FD-Score:5.07|P-value:1.95E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR211C(YLR211C_p)|FD-Score:-3.09|P-value:9.95E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YLR294C(YLR294C_d)|FD-Score:-4.86|P-value:5.93E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YOR019W(YOR019W)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YPL107W(YPL107W_p)|FD-Score:-3.76|P-value:8.60E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNR035C5.062.13E-71.66ARC35Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
YPL160W3.403.39E-40.03CDC60Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YNL282W3.373.80E-40.18POP3Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YHR068W3.197.14E-40.09DYS1Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YKL036C_d3.109.63E-40.02YKL036C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
YDR228C3.090.001020.16PCF11mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
YDL141W2.920.001740.01BPL1Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YOL040C2.910.001820.04RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YLR008C2.870.002080.02PAM18Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
YPR112C2.840.002230.03MRD1Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
YDR288W2.820.002430.07NSE3Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
YDL150W2.740.003050.15RPC53RNA polymerase III subunit C53
YLR359W2.590.004830.03ADE13Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
YDR243C2.560.005220.06PRP28RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YHR197W2.500.006260.33RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL106W8.623.36E-18AAT1Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YLR012C_p5.071.95E-7YLR012C_pPutative protein of unknown function; YLR012C is not an essential gene
YPR100W4.221.21E-5MRPL51Mitochondrial ribosomal protein of the large subunit
YJL182C_d4.221.22E-5YJL182C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
YJL183W3.924.42E-5MNN11Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
YHR025W3.846.21E-5THR1Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YOR019W3.778.02E-5YOR019WProtein of unknown function that may interact with ribosomes, based on co-purification experiments
YML013W3.768.34E-5UBX2Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis
YOR144C3.671.20E-4ELG1Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
YHL029C_p3.671.24E-4OCA5_pCytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YNL224C3.551.90E-4SQS1Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
YBR210W3.542.00E-4ERV15Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication
YCR032W3.522.17E-4BPH1Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YKL207W3.433.07E-4EMC3Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
YHR011W3.403.31E-4DIA4Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth

GO enrichment analysis for SGTC_2888
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0961.47E-13SGTC_28919063876 19.5 μMChembridge (Drug-like library)64724780.121622
0.0913.12E-12SGTC_32489135562 49.5 μMChembridge (Drug-like library)176507010.140845
0.0681.72E-7SGTC_370566-0070 1.6 μMChemDiv (Drug-like library)16266860.203704
0.0672.77E-7SGTC_30019076041 71.4 μMChembridge (Drug-like library)160042110.0649351
0.0664.29E-7SGTC_32409133527 49.5 μMChembridge (Drug-like library)176174550.123288
0.0631.45E-6SGTC_32049114183 49.5 μMChembridge (Drug-like library)170272480.174603
0.0612.81E-6SGTC_32319132313 49.5 μMChembridge (Drug-like library)49059670.106061
0.0603.81E-6SGTC_28669034245 58.4 μMChembridge (Drug-like library)64622730.126761
0.0561.67E-5SGTC_28849058502 52.0 μMChembridge (Drug-like library)64715540.169231
0.0552.43E-5SGTC_1580hydrocortisone 21-hemisuccinate 43.2 μMTimTec (Pure natural product library)166230.076087
0.0533.91E-5SGTC_32919121177 71.4 μMChembridge (Drug-like library)170156120.171053
0.0535.30E-5SGTC_12420402-0103 60.1 μMChemDiv (Drug-like library)4328680.166667
0.0526.45E-5SGTC_7441594-0068 283.0 μMChemDiv (Drug-like library)6683920.0508475amide catabolism
0.0501.12E-4SGTC_30399090270 49.5 μMChembridge (Drug-like library)171737500.229508RPP1 & pyrimidine depletion
0.0491.51E-4SGTC_8610443-0273 110.0 μMChemDiv (Drug-like library)61491690.0588235

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2883905914545.46 μM0.516476510Chembridge (Drug-like library)269.2703833.99613
SGTC_2881905895351.95 μM0.49056617122249Chembridge (Drug-like library)281.30593.77413
SGTC_6530203-001655.2 μM0.489796295302ChemDiv (Drug-like library)289.756743.44212
SGTC_3260913710949.47 μM0.47916717478346Chembridge (Drug-like library)255.311683.1561260S ribosome export
SGTC_2929901334824.6 μM0.4230772995952Chembridge (Drug-like library)310.175223.99912
SGTC_6681682-049962.6 μM0.375682214ChemDiv (Drug-like library)324.20184.10612
SGTC_3125912753449.47 μM0.370371639235Chembridge (Drug-like library)283.364844.12812
SGTC_3053909590349.47 μM0.35593217174018Chembridge (Drug-like library)317.766843.39313Golgi
SGTC_9061165-0455526 μM0.3529413252859ChemDiv (Drug-like library)304.364141.90224
SGTC_2924901016862.78 μM0.3508772993929Chembridge (Drug-like library)338.1716233.62413cell wall signaling