9063876

6-(furan-2-yl)-3-[(4-methoxyphenyl)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2891
Screen concentration 19.5 μM
Source Chembridge (Drug-like library)
PubChem CID 6472478
SMILES COC1=CC=C(C=C1)CC2=NN=C3N2N=C(S3)C4=CC=CO4
Standardized SMILES COc1ccc(Cc2nnc3sc(nn23)c4occc4)cc1
Molecular weight 312.3464
ALogP 2.79
H-bond donor count 0
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.67
% growth inhibition (Hom. pool) 6.4


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6472478
Download HIP data (tab-delimited text)  (excel)
Gene:GCD11(YER025W)|FD-Score:3.53|P-value:2.09E-4|Clearance:0.16||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:MMF1(YIL051C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.29||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:YOR146W(YOR146W_d)|FD-Score:4.28|P-value:9.31E-6|Clearance:0.75||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:GCD11(YER025W)|FD-Score:3.53|P-value:2.09E-4|Clearance:0.16||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:MMF1(YIL051C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.29||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:YOR146W(YOR146W_d)|FD-Score:4.28|P-value:9.31E-6|Clearance:0.75||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6472478
Download HOP data (tab-delimited text)  (excel)
Gene:AAT1(YKL106W)|FD-Score:5.59|P-value:1.15E-8||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ADE12(YNL220W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:AEP3(YPL005W)|FD-Score:-3.32|P-value:4.47E-4||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:AGE2(YIL044C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif Gene:ALF1(YNL148C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:AVT1(YJR001W)|FD-Score:-4.03|P-value:2.80E-5||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BTS1(YPL069C)|FD-Score:-3.13|P-value:8.86E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CLA4(YNL298W)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:DAN1(YJR150C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:GAT3(YLR013W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GIM4(YEL003W)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:ILV1(YER086W)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:JIP3(YLR331C_d)|FD-Score:-3.09|P-value:9.93E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:NDJ1(YOL104C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:PDR1(YGL013C)|FD-Score:-4.48|P-value:3.77E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PLB2(YMR006C)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine Gene:REH1(YLR387C)|FD-Score:-3.13|P-value:8.64E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:SER3(YER081W)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:SLH1(YGR271W)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SNZ1(YMR096W)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins Gene:SYO1(YDL063C)|FD-Score:-3.16|P-value:7.90E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:TIP41(YPR040W)|FD-Score:3.76|P-value:8.53E-5||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:VPS13(YLL040C)|FD-Score:-3.14|P-value:8.58E-4||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS52(YDR484W)|FD-Score:-4.01|P-value:2.98E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YER085C(YER085C_p)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Putative protein of unknown function Gene:YGL177W(YGL177W_d)|FD-Score:-3.73|P-value:9.58E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR210C(YHR210C_p)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions Gene:YKR051W(YKR051W_p)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Putative protein of unknown function Gene:YLR264C-A(YLR264C-A_p)|FD-Score:4|P-value:3.22E-5||SGD DESC:Putative protein of unknown function Gene:YMR114C(YMR114C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene Gene:YNL217W(YNL217W_p)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.49|P-value:3.48E-6||SGD DESC:Putative protein of unknown function Gene:YOR041C(YOR041C_d)|FD-Score:3.13|P-value:8.73E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Gene:AAT1(YKL106W)|FD-Score:5.59|P-value:1.15E-8||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ADE12(YNL220W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:AEP3(YPL005W)|FD-Score:-3.32|P-value:4.47E-4||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:AGE2(YIL044C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif Gene:ALF1(YNL148C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:AVT1(YJR001W)|FD-Score:-4.03|P-value:2.80E-5||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BTS1(YPL069C)|FD-Score:-3.13|P-value:8.86E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CLA4(YNL298W)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:DAN1(YJR150C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:GAT3(YLR013W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GIM4(YEL003W)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:ILV1(YER086W)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:JIP3(YLR331C_d)|FD-Score:-3.09|P-value:9.93E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:NDJ1(YOL104C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:PDR1(YGL013C)|FD-Score:-4.48|P-value:3.77E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PLB2(YMR006C)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine Gene:REH1(YLR387C)|FD-Score:-3.13|P-value:8.64E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:SER3(YER081W)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:SLH1(YGR271W)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SNZ1(YMR096W)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins Gene:SYO1(YDL063C)|FD-Score:-3.16|P-value:7.90E-4||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:TIP41(YPR040W)|FD-Score:3.76|P-value:8.53E-5||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:VPS13(YLL040C)|FD-Score:-3.14|P-value:8.58E-4||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS52(YDR484W)|FD-Score:-4.01|P-value:2.98E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBL008W-A(YBL008W-A_p)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YER085C(YER085C_p)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Putative protein of unknown function Gene:YGL177W(YGL177W_d)|FD-Score:-3.73|P-value:9.58E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR210C(YHR210C_p)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions Gene:YKR051W(YKR051W_p)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Putative protein of unknown function Gene:YLR264C-A(YLR264C-A_p)|FD-Score:4|P-value:3.22E-5||SGD DESC:Putative protein of unknown function Gene:YMR114C(YMR114C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene Gene:YNL217W(YNL217W_p)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.49|P-value:3.48E-6||SGD DESC:Putative protein of unknown function Gene:YOR041C(YOR041C_d)|FD-Score:3.13|P-value:8.73E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR146W_d4.289.31E-60.75YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YER025W3.532.09E-40.16GCD11Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YIL051C3.373.77E-40.29MMF1Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YLR223C3.080.001020.07IFH1Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
YML092C3.010.001290.12PRE8Alpha 2 subunit of the 20S proteasome
YJR016C2.900.001880.08ILV3Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YNR011C2.820.002400.07PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
YDL235C2.750.003010.02YPD1Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YNL181W_p2.730.003210.07YNL181W_pPutative oxidoreductase; required for cell viability
YMR301C2.650.004000.01ATM1Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YGL172W2.640.004150.03NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YBR254C2.610.004480.01TRS20One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YJL203W2.600.004650.03PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YMR290C2.570.005040.03HAS1ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YKL078W2.550.005420.04DHR2Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL106W5.591.15E-8AAT1Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YER086W4.661.58E-6ILV1Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YNL277W-A_p4.493.48E-6YNL277W-A_pPutative protein of unknown function
YNL148C4.201.35E-5ALF1Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YNL217W_p4.102.09E-5YNL217W_pPutative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
YLR264C-A_p4.003.22E-5YLR264C-A_pPutative protein of unknown function
YNL298W3.934.20E-5CLA4Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
YJR150C3.885.32E-5DAN1Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YER085C_p3.846.10E-5YER085C_pPutative protein of unknown function
YPR040W3.768.53E-5TIP41Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
YMR096W3.729.84E-5SNZ1Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YIL044C3.601.59E-4AGE2ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
YEL003W3.551.91E-4GIM4Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YBL008W-A_p3.472.57E-4YBL008W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YMR006C3.413.30E-4PLB2Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine

GO enrichment analysis for SGTC_2891
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1882.56E-48SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.173913
0.1624.12E-36SGTC_28999053889 58.4 μMChembridge (Drug-like library)64700520.1
0.0961.47E-13SGTC_28889058547 13.0 μMChembridge (Drug-like library)164765140.121622
0.0952.38E-13SGTC_5941487-1584 10.8 μMChemDiv (Drug-like library)50133320.0722892
0.0944.58E-13SGTC_274sirtinol 40.1 μMMiscellaneous68364420.0574713
0.0831.68E-10SGTC_28949048625 32.5 μMChembridge (Drug-like library)40928610.185714
0.0759.25E-9SGTC_24305571206 200.0 μMMiscellaneous17317710.144737
0.0759.34E-9SGTC_20895281248 129.7 μMChembridge (Fragment library)27378780.0722892superoxide
0.0713.97E-8SGTC_30399090270 49.5 μMChembridge (Drug-like library)171737500.0933333RPP1 & pyrimidine depletion
0.0708.69E-8SGTC_2042p-Dimethylaminoacetophenone 200.0 μMChembridge (Fragment library)750370.0655738
0.0663.24E-7SGTC_7560508-1999 28.3 μMChemDiv (Drug-like library)67538530.0588235RPP1 & pyrimidine depletion
0.0663.53E-7SGTC_840443-0269 128.8 μMChemDiv (Drug-like library)61500580.0641026
0.0664.56E-7SGTC_90092-0002 10.4 μMChemDiv (Drug-like library)7593680.0746269
0.0655.96E-7SGTC_22467293507 91.6 μMChembridge (Fragment library)8876560.0547945
0.0612.56E-6SGTC_1726st035556 14.6 μMTimTec (Natural product derivative library)59194390.0555556

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3210912815749.47 μM0.60377417590849Chembridge (Drug-like library)296.346983.26405
SGTC_3300912461550.48 μM0.524824903Chembridge (Drug-like library)288.368043.07205
SGTC_3101912053149.47 μM0.43548424824904Chembridge (Drug-like library)288.368043.27705
SGTC_3124912756749.47 μM0.42857117592030Chembridge (Drug-like library)323.372322.67406DNA damage response
SGTC_2996906619271.43 μM0.3870976472854Chembridge (Drug-like library)326.3481433.41906
SGTC_3117912494549.47 μM0.36923117592065Chembridge (Drug-like library)311.361622.89706
SGTC_3093911734449.47 μM0.36363624824913Chembridge (Drug-like library)337.39892.8320660S ribosome export
SGTC_3102912166949.47 μM0.36065641905072Chembridge (Drug-like library)272.368643.57504
SGTC_3306912767659.79 μM0.36065641905287Chembridge (Drug-like library)264.369783.04205
SGTC_3292912082559.78 μM0.35483924824900Chembridge (Drug-like library)276.3325233.29405