Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR260W | 5.22 | 9.11E-8 | TNA1 | High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) |
YER186C_p | 5.17 | 1.18E-7 | YER186C_p | Putative protein of unknown function |
YDR432W | 4.68 | 1.46E-6 | NPL3 | RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress |
YLR345W_p | 4.62 | 1.92E-6 | YLR345W_p | Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene |
YLR377C | 4.28 | 9.53E-6 | FBP1 | Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p |
YJR061W_p | 4.24 | 1.11E-5 | YJR061W_p | Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication |
YPL134C | 4.00 | 3.19E-5 | ODC1 | Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation |
YDR182W-A_p | 3.97 | 3.65E-5 | YDR182W-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YCR011C | 3.95 | 3.91E-5 | ADP1 | Putative ATP-dependent permease of the ABC transporter family of proteins |
YDL033C | 3.92 | 4.49E-5 | SLM3 | tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) |
YBL072C | 3.82 | 6.70E-5 | RPS8A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication |
YOL070C | 3.75 | 8.83E-5 | NBA1 | Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate |
YBL029C-A_p | 3.69 | 1.13E-4 | YBL029C-A_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica |
YBL063W | 3.62 | 1.45E-4 | KIP1 | Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions |
YHR016C | 3.53 | 2.10E-4 | YSC84 | Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication |