9047358

4-(benzenesulfonyl)-N-(3-chlorophenyl)piperazine-1-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2892
Screen concentration 58.4 μM
Source Chembridge (Drug-like library)
PubChem CID 6466771
SMILES C1CN(CCN1C(=O)NC2=CC(=CC=C2)Cl)S(=O)(=O)C3=CC=CC=C3
Standardized SMILES Clc1cccc(NC(=O)N2CCN(CC2)S(=O)(=O)c3ccccc3)c1
Molecular weight 379.8611
ALogP 2.4
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.82
% growth inhibition (Hom. pool) 2.14


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6466771
Download HIP data (tab-delimited text)  (excel)
Gene:DRE2(YKR071C)|FD-Score:3.28|P-value:5.14E-4|Clearance:0.07||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:GPI11(YDR302W)|FD-Score:3.41|P-value:3.25E-4|Clearance:0.08||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:LCP5(YER127W)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.02||SGD DESC:Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus Gene:MCM5(YLR274W)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.18||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:MPS3(YJL019W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.2||SGD DESC:Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p Gene:NUG1(YER006W)|FD-Score:-3.17|P-value:7.55E-4|Clearance:0||SGD DESC:GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus Gene:POL1(YNL102W)|FD-Score:-3.14|P-value:8.59E-4|Clearance:0||SGD DESC:Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis Gene:RFT1(YBL020W)|FD-Score:3.47|P-value:2.60E-4|Clearance:0||SGD DESC:Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein Gene:RPA190(YOR341W)|FD-Score:-3.34|P-value:4.13E-4|Clearance:0||SGD DESC:RNA polymerase I largest subunit A190 Gene:RPO26(YPR187W)|FD-Score:3.21|P-value:6.62E-4|Clearance:0.03||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SHR3(YDL212W)|FD-Score:3.45|P-value:2.84E-4|Clearance:0.04||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:SPP2(YOR148C)|FD-Score:4.24|P-value:1.11E-5|Clearance:0.39||SGD DESC:Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction Gene:SQT1(YIR012W)|FD-Score:3.18|P-value:7.24E-4|Clearance:0.16||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:TOP2(YNL088W)|FD-Score:-3.64|P-value:1.35E-4|Clearance:0||SGD DESC:Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation Gene:TRS20(YBR254C)|FD-Score:3.33|P-value:4.37E-4|Clearance:0.05||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder Gene:YJL015C(YJL015C_d)|FD-Score:-3.18|P-value:7.34E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W Gene:YPL238C(YPL238C_d)|FD-Score:-4.24|P-value:1.11E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Gene:DRE2(YKR071C)|FD-Score:3.28|P-value:5.14E-4|Clearance:0.07||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:GPI11(YDR302W)|FD-Score:3.41|P-value:3.25E-4|Clearance:0.08||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:LCP5(YER127W)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.02||SGD DESC:Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus Gene:MCM5(YLR274W)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.18||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:MPS3(YJL019W)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.2||SGD DESC:Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p Gene:NUG1(YER006W)|FD-Score:-3.17|P-value:7.55E-4|Clearance:0||SGD DESC:GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus Gene:POL1(YNL102W)|FD-Score:-3.14|P-value:8.59E-4|Clearance:0||SGD DESC:Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis Gene:RFT1(YBL020W)|FD-Score:3.47|P-value:2.60E-4|Clearance:0||SGD DESC:Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein Gene:RPA190(YOR341W)|FD-Score:-3.34|P-value:4.13E-4|Clearance:0||SGD DESC:RNA polymerase I largest subunit A190 Gene:RPO26(YPR187W)|FD-Score:3.21|P-value:6.62E-4|Clearance:0.03||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SHR3(YDL212W)|FD-Score:3.45|P-value:2.84E-4|Clearance:0.04||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:SPP2(YOR148C)|FD-Score:4.24|P-value:1.11E-5|Clearance:0.39||SGD DESC:Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction Gene:SQT1(YIR012W)|FD-Score:3.18|P-value:7.24E-4|Clearance:0.16||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:TOP2(YNL088W)|FD-Score:-3.64|P-value:1.35E-4|Clearance:0||SGD DESC:Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation Gene:TRS20(YBR254C)|FD-Score:3.33|P-value:4.37E-4|Clearance:0.05||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder Gene:YJL015C(YJL015C_d)|FD-Score:-3.18|P-value:7.34E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W Gene:YPL238C(YPL238C_d)|FD-Score:-4.24|P-value:1.11E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6466771
Download HOP data (tab-delimited text)  (excel)
Gene:ADP1(YCR011C)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative ATP-dependent permease of the ABC transporter family of proteins Gene:AMA1(YGR225W)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:APE1(YKL103C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:CLA4(YNL298W)|FD-Score:-3.92|P-value:4.45E-5||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:CUR1(YPR158W)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DAP1(YPL170W)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:FBP1(YLR377C)|FD-Score:4.28|P-value:9.53E-6||SGD DESC:Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p Gene:ILM1(YJR118C)|FD-Score:3.42|P-value:3.09E-4||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:KIP1(YBL063W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions Gene:KTR2(YKR061W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication Gene:LSB6(YJL100W)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MEF2(YJL102W)|FD-Score:-3.1|P-value:9.67E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:NBA1(YOL070C)|FD-Score:3.75|P-value:8.83E-5||SGD DESC:Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate Gene:NPL3(YDR432W)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:ODC1(YPL134C)|FD-Score:4|P-value:3.19E-5||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:POP2(YNR052C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:RPS8A(YBL072C)|FD-Score:3.82|P-value:6.70E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SLH1(YGR271W)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SLM3(YDL033C)|FD-Score:3.92|P-value:4.49E-5||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SLS1(YLR139C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery Gene:TNA1(YGR260W)|FD-Score:5.22|P-value:9.11E-8||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:UBR2(YLR024C)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YBL029C-A(YBL029C-A_p)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YCK1(YHR135C)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication Gene:YDR182W-A(YDR182W-A_p)|FD-Score:3.97|P-value:3.65E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR514C(YDR514C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YEL057C(YEL057C_p)|FD-Score:-3.73|P-value:9.75E-5||SGD DESC:Protein of unknown function involved in telomere maintenance; target of UME6 regulation Gene:YER186C(YER186C_p)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Putative protein of unknown function Gene:YGR064W(YGR064W_d)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YJR020W(YJR020W_d)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR061W(YJR061W_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YLR345W(YLR345W_p)|FD-Score:4.62|P-value:1.92E-6||SGD DESC:Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene Gene:YSC84(YHR016C)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication Gene:ADP1(YCR011C)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative ATP-dependent permease of the ABC transporter family of proteins Gene:AMA1(YGR225W)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:APE1(YKL103C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:CLA4(YNL298W)|FD-Score:-3.92|P-value:4.45E-5||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:CUR1(YPR158W)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DAP1(YPL170W)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:FBP1(YLR377C)|FD-Score:4.28|P-value:9.53E-6||SGD DESC:Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p Gene:ILM1(YJR118C)|FD-Score:3.42|P-value:3.09E-4||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:KIP1(YBL063W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions Gene:KTR2(YKR061W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication Gene:LSB6(YJL100W)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MEF2(YJL102W)|FD-Score:-3.1|P-value:9.67E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:NBA1(YOL070C)|FD-Score:3.75|P-value:8.83E-5||SGD DESC:Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate Gene:NPL3(YDR432W)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:ODC1(YPL134C)|FD-Score:4|P-value:3.19E-5||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:POP2(YNR052C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:RPS8A(YBL072C)|FD-Score:3.82|P-value:6.70E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SLH1(YGR271W)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SLM3(YDL033C)|FD-Score:3.92|P-value:4.49E-5||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SLS1(YLR139C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery Gene:TNA1(YGR260W)|FD-Score:5.22|P-value:9.11E-8||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:UBR2(YLR024C)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YBL029C-A(YBL029C-A_p)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YCK1(YHR135C)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication Gene:YDR182W-A(YDR182W-A_p)|FD-Score:3.97|P-value:3.65E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR514C(YDR514C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YEL057C(YEL057C_p)|FD-Score:-3.73|P-value:9.75E-5||SGD DESC:Protein of unknown function involved in telomere maintenance; target of UME6 regulation Gene:YER186C(YER186C_p)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Putative protein of unknown function Gene:YGR064W(YGR064W_d)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YJR020W(YJR020W_d)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR061W(YJR061W_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YLR345W(YLR345W_p)|FD-Score:4.62|P-value:1.92E-6||SGD DESC:Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene Gene:YSC84(YHR016C)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR148C4.241.11E-50.39SPP2Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YLR274W3.855.82E-50.18MCM5Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YJL019W3.671.19E-40.20MPS3Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
YBL020W3.472.60E-40.00RFT1Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
YER127W3.472.61E-40.02LCP5Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YDL212W3.452.84E-40.04SHR3Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YDR302W3.413.25E-40.08GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YBR254C3.334.37E-40.05TRS20One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YKR071C3.285.14E-40.07DRE2Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
YPR187W3.216.62E-40.03RPO26RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YIR012W3.187.24E-40.16SQT1Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YJR042W3.020.001250.14NUP85Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
YOR257W2.880.001990.01CDC31Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YBR265W2.870.002060.02TSC103-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
YHR148W2.850.002180.02IMP3Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR260W5.229.11E-8TNA1High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YER186C_p5.171.18E-7YER186C_pPutative protein of unknown function
YDR432W4.681.46E-6NPL3RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress
YLR345W_p4.621.92E-6YLR345W_pSimilar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
YLR377C4.289.53E-6FBP1Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p
YJR061W_p4.241.11E-5YJR061W_pPutative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
YPL134C4.003.19E-5ODC1Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YDR182W-A_p3.973.65E-5YDR182W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YCR011C3.953.91E-5ADP1Putative ATP-dependent permease of the ABC transporter family of proteins
YDL033C3.924.49E-5SLM3tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
YBL072C3.826.70E-5RPS8AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
YOL070C3.758.83E-5NBA1Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
YBL029C-A_p3.691.13E-4YBL029C-A_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YBL063W3.621.45E-4KIP1Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
YHR016C3.532.10E-4YSC84Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2892
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0654.96E-7SGTC_2683piperine 63.0 μMTimTec (Pure natural product library)6380240.15942
0.0621.73E-6SGTC_28979048598 13.0 μMChembridge (Drug-like library)64674040.212121
0.0613.06E-6SGTC_30069075424 71.4 μMChembridge (Drug-like library)74651810.191176
0.0571.12E-5SGTC_2496diffractaic acid 79.8 μMMicrosource (Natural product library)948700.0821918
0.0543.38E-5SGTC_2115tiliquinol 12.8 μMChembridge (Fragment library)712080.0645161
0.0535.15E-5SGTC_9661300-0360 30.2 μMChemDiv (Drug-like library)705880.0952381heme requiring
0.0519.22E-5SGTC_260nsc-65238 4.0 μMMiscellaneous32462520.0641026endomembrane recycling
0.0501.22E-4SGTC_1822st052468 42.0 μMTimTec (Natural product derivative library)28736780.163043
0.0491.91E-4SGTC_31929110362 49.5 μMChembridge (Drug-like library)166494800.153846mitochondrial processes
0.0472.71E-4SGTC_1996st072960 66.8 μMTimTec (Natural product derivative library)17194050.0657895
0.0473.19E-4SGTC_5914299-0174 154.0 μMChemDiv (Drug-like library)55090880.106667
0.0473.46E-4SGTC_25422-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100.0 μMMicrosource (Natural product library)50247450.0144928
0.0446.80E-4SGTC_12103013-0140 750.0 nMChemDiv (Drug-like library)9059730.0821918
0.0439.73E-4SGTC_28137971799 71.4 μMChembridge (Drug-like library)22340540.121622
0.0430.00103SGTC_22737815444 169.1 μMChembridge (Fragment library)28246160.114286

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2802792581554.55 μM0.4193551262923Chembridge (Drug-like library)394.872463.07125
SGTC_2896905265671.43 μM0.4098366469436Chembridge (Drug-like library)369.887763.62913endomembrane recycling
SGTC_2874904390471.43 μM0.3928574463428Chembridge (Drug-like library)312.38460.9606
SGTC_1460k062-00599.15 μM0.379311373085ChemDiv (Drug-like library)368.2328434.31513Golgi
SGTC_2942905277762.25 μM0.3636366469503Chembridge (Drug-like library)284.1131234.14912
SGTC_2847900566171.43 μM0.3620692991449Chembridge (Drug-like library)303.740263.42913
SGTC_12550566-0045221 μM0.3571432788469ChemDiv (Drug-like library)304.728323.04223excess fatty acid
SGTC_13983558-0053112 μM0.3513514532369ChemDiv (Drug-like library)584.491923.72228
SGTC_2392N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide200 μM0.350877803109Chembridge (Fragment library)248.665061.08522
SGTC_2787528454071.43 μM0.350877736958Chembridge (Drug-like library)291.729563.24613