| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIL034C | 6.12 | 4.56E-10 | CAP2 | Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress |
| YGR283C | 5.43 | 2.84E-8 | YGR283C | Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus |
| YNL217W_p | 5.20 | 9.75E-8 | YNL217W_p | Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate |
| YMR194W | 4.84 | 6.35E-7 | RPL36A | Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication |
| YKL016C | 4.24 | 1.11E-5 | ATP7 | Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
| YDL214C | 4.23 | 1.18E-5 | PRR2 | Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance |
| YLR263W | 4.22 | 1.22E-5 | RED1 | Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p |
| YMR031W-A_d | 4.11 | 1.99E-5 | YMR031W-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C |
| YJL138C | 4.03 | 2.79E-5 | TIF2 | Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication |
| YDR143C | 3.95 | 3.90E-5 | SAN1 | Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition |
| YGL109W_d | 3.92 | 4.35E-5 | YGL109W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
| YFL040W_p | 3.89 | 5.04E-5 | YFL040W_p | Putative transporter, member of the sugar porter family; YFL040W is not an essential gene |
| YBR156C | 3.82 | 6.79E-5 | SLI15 | Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly |
| YHL039W | 3.75 | 8.75E-5 | EFM1 | Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| YPR135W | 3.74 | 9.19E-5 | CTF4 | Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion |
