Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL209C | 3.98 | 3.47E-5 | 0.46 | CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 |
YOR116C | 3.89 | 5.06E-5 | 0.46 | RPO31 | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
YOR218C_d | 3.43 | 3.07E-4 | 0.30 | YOR218C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W |
YLR310C | 3.12 | 9.02E-4 | 0.19 | CDC25 | Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 |
YOR151C | 2.93 | 0.00169 | 0.06 | RPB2 | RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit |
YOR257W | 2.87 | 0.00205 | 0.10 | CDC31 | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
YLR078C | 2.77 | 0.00277 | 0.02 | BOS1 | v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi |
YBR154C | 2.76 | 0.00293 | 0.12 | RPB5 | RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation |
YGL069C_d | 2.64 | 0.00417 | 0.04 | YGL069C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance |
YOR210W | 2.60 | 0.00467 | 0.03 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YDL030W | 2.57 | 0.00503 | 0.03 | PRP9 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex |
YNL062C | 2.54 | 0.00547 | 0.12 | GCD10 | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
YGR024C | 2.43 | 0.00765 | 0.13 | THG1 | tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes |
YKR022C | 2.29 | 0.01090 | 0.06 | NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly |
YBR256C | 2.24 | 0.01260 | 0.10 | RIB5 | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway |