9056270

N-(2-morpholin-4-ylethyl)-3-oxobenzo[f]chromene-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2898
Screen concentration 58.4 μM
Source Chembridge (Drug-like library)
PubChem CID 19154699
SMILES C1COCCN1CCNC(=O)C2=CC3=C(C=CC4=CC=CC=C43)OC2=O
Standardized SMILES O=C(NCCN1CCOCC1)C2=Cc3c(OC2=O)ccc4ccccc34
Molecular weight 352.3838
ALogP 1.8
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.15
% growth inhibition (Hom. pool) 1.2


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 19154699
Download HIP data (tab-delimited text)  (excel)
Gene:CIA2(YHR122W)|FD-Score:-3.1|P-value:9.72E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:DIS3(YOL021C)|FD-Score:-3.23|P-value:6.24E-4|Clearance:0||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:DRE2(YKR071C)|FD-Score:-3.1|P-value:9.56E-4|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:EBP2(YKL172W)|FD-Score:-4.29|P-value:9.03E-6|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:HEM15(YOR176W)|FD-Score:-3.32|P-value:4.47E-4|Clearance:0||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:IFH1(YLR223C)|FD-Score:3.14|P-value:8.32E-4|Clearance:0.21||SGD DESC:Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing Gene:NUD1(YOR373W)|FD-Score:-3.88|P-value:5.31E-5|Clearance:0||SGD DESC:Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance Gene:PRE3(YJL001W)|FD-Score:-3.39|P-value:3.52E-4|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:RPB2(YOR151C)|FD-Score:-3.81|P-value:7.05E-5|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit Gene:CIA2(YHR122W)|FD-Score:-3.1|P-value:9.72E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:DIS3(YOL021C)|FD-Score:-3.23|P-value:6.24E-4|Clearance:0||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:DRE2(YKR071C)|FD-Score:-3.1|P-value:9.56E-4|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:EBP2(YKL172W)|FD-Score:-4.29|P-value:9.03E-6|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:HEM15(YOR176W)|FD-Score:-3.32|P-value:4.47E-4|Clearance:0||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:IFH1(YLR223C)|FD-Score:3.14|P-value:8.32E-4|Clearance:0.21||SGD DESC:Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing Gene:NUD1(YOR373W)|FD-Score:-3.88|P-value:5.31E-5|Clearance:0||SGD DESC:Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance Gene:PRE3(YJL001W)|FD-Score:-3.39|P-value:3.52E-4|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:RPB2(YOR151C)|FD-Score:-3.81|P-value:7.05E-5|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 19154699
Download HOP data (tab-delimited text)  (excel)
Gene:BSC4(YNL269W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:CLD1(YGR110W)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 Gene:COS12(YGL263W)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:COX19(YLL018C-A)|FD-Score:-3.12|P-value:8.94E-4||SGD DESC:Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:ECM27(YJR106W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p Gene:EMP70(YLR083C)|FD-Score:-3.13|P-value:8.64E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:FTH1(YBR207W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:GRH1(YDR517W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:HMX1(YLR205C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants Gene:KIN1(YDR122W)|FD-Score:4.29|P-value:8.99E-6||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LOA1(YPR139C)|FD-Score:-3.25|P-value:5.68E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:MCT1(YOR221C)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MF(ALPHA)1(YPL187W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:PIN4(YBL051C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PTC4(YBR125C)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity Gene:RNQ1(YCL028W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate Gene:RPL33B(YOR234C)|FD-Score:-3.75|P-value:8.88E-5||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:-3.19|P-value:7.10E-4||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SAM2(YDR502C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SEC66(YBR171W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:UBP15(YMR304W)|FD-Score:-3.16|P-value:7.85E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:URC2(YDR520C_p)|FD-Score:-3.76|P-value:8.59E-5||SGD DESC:Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism Gene:YDL183C(YDL183C)|FD-Score:-3.19|P-value:7.12E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR521W(YDR521W_d)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Gene:YEL010W(YEL010W_d)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL040W(YFL040W_p)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Putative transporter, member of the sugar porter family; YFL040W is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:6.63|P-value:1.68E-11||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YHR033W(YHR033W_p)|FD-Score:4.36|P-value:6.46E-6||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication Gene:YJR079W(YJR079W_p)|FD-Score:-4.26|P-value:1.04E-5||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:Putative protein of unknown function Gene:YNL285W(YNL285W_d)|FD-Score:-3.35|P-value:3.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL185W(YPL185W_d)|FD-Score:-3.8|P-value:7.26E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:BSC4(YNL269W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:CLD1(YGR110W)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 Gene:COS12(YGL263W)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:COX19(YLL018C-A)|FD-Score:-3.12|P-value:8.94E-4||SGD DESC:Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:ECM27(YJR106W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p Gene:EMP70(YLR083C)|FD-Score:-3.13|P-value:8.64E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:FTH1(YBR207W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:GRH1(YDR517W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:HMX1(YLR205C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants Gene:KIN1(YDR122W)|FD-Score:4.29|P-value:8.99E-6||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LOA1(YPR139C)|FD-Score:-3.25|P-value:5.68E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:MCT1(YOR221C)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MF(ALPHA)1(YPL187W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:PIN4(YBL051C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PTC4(YBR125C)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity Gene:RNQ1(YCL028W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate Gene:RPL33B(YOR234C)|FD-Score:-3.75|P-value:8.88E-5||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:-3.19|P-value:7.10E-4||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SAM2(YDR502C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SEC66(YBR171W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:UBP15(YMR304W)|FD-Score:-3.16|P-value:7.85E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:URC2(YDR520C_p)|FD-Score:-3.76|P-value:8.59E-5||SGD DESC:Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism Gene:YDL183C(YDL183C)|FD-Score:-3.19|P-value:7.12E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR521W(YDR521W_d)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Gene:YEL010W(YEL010W_d)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL040W(YFL040W_p)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Putative transporter, member of the sugar porter family; YFL040W is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:6.63|P-value:1.68E-11||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YHR033W(YHR033W_p)|FD-Score:4.36|P-value:6.46E-6||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication Gene:YJR079W(YJR079W_p)|FD-Score:-4.26|P-value:1.04E-5||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:Putative protein of unknown function Gene:YNL285W(YNL285W_d)|FD-Score:-3.35|P-value:3.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL185W(YPL185W_d)|FD-Score:-3.8|P-value:7.26E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR223C3.148.32E-40.21IFH1Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
YDR236C2.930.001680.12FMN1Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
YIR012W2.810.002490.14SQT1Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YJL203W2.670.003770.02PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YJR016C2.650.003990.10ILV3Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YNR011C2.550.005340.08PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
YMR290C2.480.006630.13HAS1ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YHR197W2.340.009570.00RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YLR007W2.340.009690.06NSE1Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
YBR167C2.270.011500.09POP7Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR339C2.180.014700.08FCF1Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
YMR047C2.100.017900.05NUP116FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
YGL116W2.050.020300.01CDC20Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
YKL052C2.040.020600.00ASK1Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
YDL140C2.040.020806.38E-4RPO21RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL109W_d6.631.68E-11YGL109W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
YEL010W_d4.721.19E-6YEL010W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL277W-A_p4.592.26E-6YNL277W-A_pPutative protein of unknown function
YHR033W_p4.366.46E-6YHR033W_pPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
YDR122W4.298.99E-6KIN1Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YBR171W4.191.40E-5SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YPL187W3.865.72E-5MF(ALPHA)1Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YDR517W3.621.45E-4GRH1Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
YBR207W3.413.27E-4FTH1Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
YDR502C3.334.32E-4SAM2S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
YJR106W3.314.59E-4ECM27Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
YLR205C3.314.61E-4HMX1ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
YDR521W_d3.236.09E-4YDR521W_dDubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
YFL040W_p3.206.80E-4YFL040W_pPutative transporter, member of the sugar porter family; YFL040W is not an essential gene
YNL269W3.206.90E-4BSC4Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p

GO enrichment analysis for SGTC_2898
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2162.17E-63SGTC_28999053889 58.4 μMChembridge (Drug-like library)64700520.148148
0.1631.87E-36SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.102564
0.0773.72E-9SGTC_32979117502 71.4 μMChembridge (Drug-like library)74537200.0963855
0.0691.23E-7SGTC_33139133968 57.0 μMChembridge (Drug-like library)14946430.0978261
0.0621.77E-6SGTC_22629014885 67.5 μMChembridge (Fragment library)64574240.106667
0.0612.32E-6SGTC_28949048625 32.5 μMChembridge (Drug-like library)40928610.157895
0.0613.12E-6SGTC_2576guaiol 23.1 μMMicrosource (Natural product library)2278290.027027
0.0604.37E-6SGTC_12630774-1208 64.8 μMChemDiv (Drug-like library)9065850.164384
0.0594.85E-6SGTC_23739071805 200.0 μMChembridge (Fragment library)101490090.0923077
0.0596.12E-6SGTC_31769106582 49.5 μMChembridge (Drug-like library)170180270.113924
0.0596.38E-6SGTC_23165844804 197.4 μMChembridge (Fragment library)7768130.0625
0.0571.25E-5SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.144231
0.0542.80E-5SGTC_2568diosmetin 100.0 μMMicrosource (Natural product library)52816120.111111
0.0543.04E-5SGTC_1938st074717 56.4 μMTimTec (Natural product derivative library)172509790.156627
0.0543.17E-5SGTC_31689103419 49.5 μMChembridge (Drug-like library)166492560.11904860S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_7510833-0568350 μM0.4393946954252ChemDiv (Drug-like library)311.358322.70924
SGTC_20935331342194.4 μM0.36065633839Chembridge (Fragment library)243.300982.25713
SGTC_22047233102200 μM0.3593752172480Chembridge (Fragment library)229.231341.6841360S ribosome export
SGTC_2910794840525.97 μM0.3333332971328Chembridge (Drug-like library)417.748323.49214plasma membrane duress
SGTC_14801070-004441.2 μM0.3225813124987ChemDiv (Drug-like library)294.390783.41702
SGTC_1628st00425277.7 μM0.318182692968TimTec (Natural product derivative library)257.28452.4713
SGTC_2435hr heat shock (37°C) + splitomicin1 μM0.35269Miscellaneous198.21732.83102heat shock/prefoldin
SGTC_424splitomicin100 mM0.35269Miscellaneous198.21732.83102
SGTC_1910st06235260.4 μM0.2894742245730TimTec (Natural product derivative library)287.310481.94514
SGTC_1821st05346565.6 μM0.287879675086TimTec (Natural product derivative library)282.090121.81613