9053889

1-(4-butylphenyl)-3-(oxolan-2-ylmethyl)urea

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2899
Screen concentration 58.4 μM
Source Chembridge (Drug-like library)
PubChem CID 6470052
SMILES CCCCC1=CC=C(C=C1)NC(=O)NCC2CCCO2
Standardized SMILES CCCCc1ccc(NC(=O)NCC2CCCO2)cc1
Molecular weight 276.374
ALogP 3.16
H-bond donor count 2
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.15
% growth inhibition (Hom. pool) 1.2


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6470052
Download HIP data (tab-delimited text)  (excel)
Gene:COG2(YGR120C)|FD-Score:3.3|P-value:4.90E-4|Clearance:0.03||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:EBP2(YKL172W)|FD-Score:-3.2|P-value:6.77E-4|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:GCD2(YGR083C)|FD-Score:-3.1|P-value:9.70E-4|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:IFH1(YLR223C)|FD-Score:3.63|P-value:1.39E-4|Clearance:0.1||SGD DESC:Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing Gene:MEC1(YBR136W)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.24||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MMF1(YIL051C)|FD-Score:5.21|P-value:9.40E-8|Clearance:1.58||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:PRP21(YJL203W)|FD-Score:3.26|P-value:5.54E-4|Clearance:0.22||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PWP2(YCR057C)|FD-Score:-3.35|P-value:3.98E-4|Clearance:0||SGD DESC:Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis Gene:RLI1(YDR091C)|FD-Score:-3.13|P-value:8.74E-4|Clearance:0||SGD DESC:Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species Gene:RPR2(YIR015W)|FD-Score:-4.34|P-value:7.25E-6|Clearance:0||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:SPP41(YDR464W)|FD-Score:-3.9|P-value:4.78E-5|Clearance:0||SGD DESC:Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 Gene:SRP72(YPL210C)|FD-Score:-3.1|P-value:9.61E-4|Clearance:0||SGD DESC:Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane Gene:COG2(YGR120C)|FD-Score:3.3|P-value:4.90E-4|Clearance:0.03||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:EBP2(YKL172W)|FD-Score:-3.2|P-value:6.77E-4|Clearance:0||SGD DESC:Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering Gene:GCD2(YGR083C)|FD-Score:-3.1|P-value:9.70E-4|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:IFH1(YLR223C)|FD-Score:3.63|P-value:1.39E-4|Clearance:0.1||SGD DESC:Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing Gene:MEC1(YBR136W)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.24||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MMF1(YIL051C)|FD-Score:5.21|P-value:9.40E-8|Clearance:1.58||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:PRP21(YJL203W)|FD-Score:3.26|P-value:5.54E-4|Clearance:0.22||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PWP2(YCR057C)|FD-Score:-3.35|P-value:3.98E-4|Clearance:0||SGD DESC:Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis Gene:RLI1(YDR091C)|FD-Score:-3.13|P-value:8.74E-4|Clearance:0||SGD DESC:Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species Gene:RPR2(YIR015W)|FD-Score:-4.34|P-value:7.25E-6|Clearance:0||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:SPP41(YDR464W)|FD-Score:-3.9|P-value:4.78E-5|Clearance:0||SGD DESC:Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 Gene:SRP72(YPL210C)|FD-Score:-3.1|P-value:9.61E-4|Clearance:0||SGD DESC:Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6470052
Download HOP data (tab-delimited text)  (excel)
Gene:ALF1(YNL148C)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:ARO3(YDR035W)|FD-Score:-4.02|P-value:2.96E-5||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ATG18(YFR021W)|FD-Score:4.08|P-value:2.29E-5||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:AVT5(YBL089W)|FD-Score:-3.29|P-value:4.94E-4||SGD DESC:Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication Gene:CAF20(YOR276W)|FD-Score:4.8|P-value:7.89E-7||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:COX19(YLL018C-A)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CPD1(YGR247W)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress Gene:CUR1(YPR158W)|FD-Score:3.77|P-value:8.05E-5||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DAN1(YJR150C)|FD-Score:7.26|P-value:1.93E-13||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:EDC1(YGL222C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:EMP24(YGL200C)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:HAP4(YKL109W)|FD-Score:4.31|P-value:8.26E-6||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex Gene:HFA1(YMR207C)|FD-Score:-3.82|P-value:6.79E-5||SGD DESC:Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ILM1(YJR118C)|FD-Score:3.88|P-value:5.23E-5||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:KIN1(YDR122W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LOA1(YPR139C)|FD-Score:-4.45|P-value:4.31E-6||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:LYS1(YIR034C)|FD-Score:-3.27|P-value:5.37E-4||SGD DESC:Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity Gene:MNN11(YJL183W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MZM1(YDR493W)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:OSW2(YLR054C)|FD-Score:-3.13|P-value:8.80E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:RAD17(YOR368W)|FD-Score:3.39|P-value:3.52E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RIC1(YLR039C)|FD-Score:3.5|P-value:2.37E-4||SGD DESC:Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes Gene:RIM4(YHL024W)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RPH1(YER169W)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication Gene:SER3(YER081W)|FD-Score:4.32|P-value:7.89E-6||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:SPO19(YPL130W)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation Gene:SRO9(YCL037C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:SSD1(YDR293C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TMN2(YDR107C)|FD-Score:3.11|P-value:9.51E-4||SGD DESC:Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments Gene:TUS1(YLR425W)|FD-Score:4.39|P-value:5.80E-6||SGD DESC:Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Gene:YDR521W(YDR521W_d)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Gene:YGL039W(YGL039W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols Gene:YGL109W(YGL109W_d)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YJR079W(YJR079W_p)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.03|P-value:2.83E-5||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YMR074C(YMR074C)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.86|P-value:5.60E-5||SGD DESC:Putative protein of unknown function Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.99|P-value:3.00E-7||SGD DESC:Putative protein of unknown function Gene:ALF1(YNL148C)|FD-Score:4.05|P-value:2.54E-5||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:ARO3(YDR035W)|FD-Score:-4.02|P-value:2.96E-5||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ATG18(YFR021W)|FD-Score:4.08|P-value:2.29E-5||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:AVT5(YBL089W)|FD-Score:-3.29|P-value:4.94E-4||SGD DESC:Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication Gene:CAF20(YOR276W)|FD-Score:4.8|P-value:7.89E-7||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:COX19(YLL018C-A)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CPD1(YGR247W)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress Gene:CUR1(YPR158W)|FD-Score:3.77|P-value:8.05E-5||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DAN1(YJR150C)|FD-Score:7.26|P-value:1.93E-13||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:EDC1(YGL222C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:EMP24(YGL200C)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:HAP4(YKL109W)|FD-Score:4.31|P-value:8.26E-6||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex Gene:HFA1(YMR207C)|FD-Score:-3.82|P-value:6.79E-5||SGD DESC:Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ILM1(YJR118C)|FD-Score:3.88|P-value:5.23E-5||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:KIN1(YDR122W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LOA1(YPR139C)|FD-Score:-4.45|P-value:4.31E-6||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:LYS1(YIR034C)|FD-Score:-3.27|P-value:5.37E-4||SGD DESC:Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity Gene:MNN11(YJL183W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MZM1(YDR493W)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog Gene:OSW2(YLR054C)|FD-Score:-3.13|P-value:8.80E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:RAD17(YOR368W)|FD-Score:3.39|P-value:3.52E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RIC1(YLR039C)|FD-Score:3.5|P-value:2.37E-4||SGD DESC:Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes Gene:RIM4(YHL024W)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RPH1(YER169W)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication Gene:SER3(YER081W)|FD-Score:4.32|P-value:7.89E-6||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication Gene:SPO19(YPL130W)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation Gene:SRO9(YCL037C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:SSD1(YDR293C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TMN2(YDR107C)|FD-Score:3.11|P-value:9.51E-4||SGD DESC:Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments Gene:TUS1(YLR425W)|FD-Score:4.39|P-value:5.80E-6||SGD DESC:Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Gene:YDR521W(YDR521W_d)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Gene:YGL039W(YGL039W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols Gene:YGL109W(YGL109W_d)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YJR079W(YJR079W_p)|FD-Score:-3.38|P-value:3.59E-4||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.03|P-value:2.83E-5||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YMR074C(YMR074C)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR175W-A(YMR175W-A_p)|FD-Score:3.86|P-value:5.60E-5||SGD DESC:Putative protein of unknown function Gene:YNL277W-A(YNL277W-A_p)|FD-Score:4.99|P-value:3.00E-7||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YIL051C5.219.40E-81.58MMF1Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YLR223C3.631.39E-40.10IFH1Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
YBR136W3.542.03E-40.24MEC1Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
YGR120C3.304.90E-40.03COG2Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YJL203W3.265.54E-40.22PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YLR196W3.040.001190.03PWP1Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YDR236C3.000.001330.01FMN1Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
YNR011C3.000.001370.02PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
YBR236C2.980.001460.29ABD1Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YGR156W2.680.003660.04PTI1Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YLR277C2.650.004060.15YSH1Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication
YML092C2.500.006250.01PRE8Alpha 2 subunit of the 20S proteasome
YPR086W2.490.006410.00SUA7Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
YKL036C_d2.490.006450.01YKL036C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
YDL235C2.480.006600.00YPD1Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJR150C7.261.93E-13DAN1Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YNL277W-A_p4.993.00E-7YNL277W-A_pPutative protein of unknown function
YOR276W4.807.89E-7CAF20Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YLR425W4.395.80E-6TUS1Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YER081W4.327.89E-6SER33-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
YKL109W4.318.26E-6HAP4Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YFR021W4.082.29E-5ATG18Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
YNL148C4.052.54E-5ALF1Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YKL106C-A_p4.032.83E-5YKL106C-A_pPutative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
YER169W3.983.49E-5RPH1JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
YJR118C3.885.23E-5ILM1Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YMR175W-A_p3.865.60E-5YMR175W-A_pPutative protein of unknown function
YPR158W3.778.05E-5CUR1Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication
YGL039W3.711.02E-4YGL039WOxidoreductase shown to reduce carbonyl compounds to chiral alcohols
YGL222C3.661.27E-4EDC1RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress

GO enrichment analysis for SGTC_2899
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2162.17E-63SGTC_28989056270 58.4 μMChembridge (Drug-like library)191546990.148148
0.2129.84E-61SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.215385
0.1624.12E-36SGTC_28919063876 19.5 μMChembridge (Drug-like library)64724780.1
0.0672.50E-7SGTC_30259087895 49.5 μMChembridge (Drug-like library)171736410.108434PDR1
0.0612.88E-6SGTC_23246149169 200.0 μMChembridge (Fragment library)28882310.140845
0.0571.10E-5SGTC_28949048625 32.5 μMChembridge (Drug-like library)40928610.246154
0.0561.72E-5SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.131313
0.0542.94E-5SGTC_12021988-0068 29.6 μMChemDiv (Drug-like library)28504800.0941176RNA processing & uracil transport
0.0534.25E-5SGTC_23165844804 197.4 μMChembridge (Fragment library)7768130.0684932
0.0535.00E-5SGTC_2023594-0513 34.8 μMChemDiv (Drug-like library)7084290.0597015PDR1
0.0526.75E-5SGTC_33139133968 57.0 μMChembridge (Drug-like library)14946430.146341
0.0527.38E-5SGTC_9391165-0479 45.3 μMChemDiv (Drug-like library)13773470.114754
0.0518.19E-5SGTC_1862st057513 3.8 μMTimTec (Natural product derivative library)53931630.0694444
0.0491.63E-4SGTC_22467293507 91.6 μMChembridge (Fragment library)8876560.136364
0.0482.28E-4SGTC_33429147791 14.5 μMChembridge (Drug-like library)18381680.0823529

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2837900847645.46 μM0.4590162992805Chembridge (Drug-like library)328.3841.21226
SGTC_3227913076849.47 μM0.437517720899Chembridge (Drug-like library)313.390823.57913
SGTC_13742889-5571141 μM0.406782853281ChemDiv (Drug-like library)269.724041.89613RSC complex & mRNA processing
SGTC_3092911724849.47 μM0.36923117141857Chembridge (Drug-like library)346.808063.52923cell wall signaling
SGTC_3035909130349.47 μM0.36206925237002Chembridge (Drug-like library)275.38593.54102
SGTC_2969909140828.7 μM0.354286311Chembridge (Drug-like library)254.326923.31812
SGTC_3103912082249.47 μM0.33333317141819Chembridge (Drug-like library)327.374342.9414
SGTC_3027908954149.47 μM0.3220349943819Chembridge (Drug-like library)288.427723.92802fatty acid desaturase (OLE1)
SGTC_2961222-003974.9 μM0.3214295984176ChemDiv (Drug-like library)218.291524.22812
SGTC_810411-00469.97 μM0.30909112925265ChemDiv (Drug-like library)297.230645.4701