Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJR150C | 7.26 | 1.93E-13 | DAN1 | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth |
YNL277W-A_p | 4.99 | 3.00E-7 | YNL277W-A_p | Putative protein of unknown function |
YOR276W | 4.80 | 7.89E-7 | CAF20 | Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E |
YLR425W | 4.39 | 5.80E-6 | TUS1 | Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate |
YER081W | 4.32 | 7.89E-6 | SER3 | 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication |
YKL109W | 4.31 | 8.26E-6 | HAP4 | Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex |
YFR021W | 4.08 | 2.29E-5 | ATG18 | Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood |
YNL148C | 4.05 | 2.54E-5 | ALF1 | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |
YKL106C-A_p | 4.03 | 2.83E-5 | YKL106C-A_p | Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi |
YER169W | 3.98 | 3.49E-5 | RPH1 | JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication |
YJR118C | 3.88 | 5.23E-5 | ILM1 | Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth |
YMR175W-A_p | 3.86 | 5.60E-5 | YMR175W-A_p | Putative protein of unknown function |
YPR158W | 3.77 | 8.05E-5 | CUR1 | Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication |
YGL039W | 3.71 | 1.02E-4 | YGL039W | Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols |
YGL222C | 3.66 | 1.27E-4 | EDC1 | RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress |