2043-6722

(E)-1-(3,4-dihydro-2H-quinolin-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_290
Screen concentration 48.1 μM
Source ChemDiv (Drug-like library)
PubChem CID 773758
SMILES C1CC2=CC=CC=C2N(C1)C(=O)C=CC3=CC=C(C=C3)F
Standardized SMILES Fc1ccc(C=CC(=O)N2CCCc3ccccc23)cc1
Molecular weight 281.3241
ALogP 4.02
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 16.14
% growth inhibition (Hom. pool) 11.98


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 773758
Download HIP data (tab-delimited text)  (excel)
Gene:PRI2(YKL045W)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.26||SGD DESC:Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair Gene:RPP1(YHR062C)|FD-Score:5.14|P-value:1.35E-7|Clearance:0.08||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC13(YLR208W)|FD-Score:22.2|P-value:8.80E-110|Clearance:17.09||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SEC31(YDL195W)|FD-Score:5.06|P-value:2.10E-7|Clearance:1.75||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SYF1(YDR416W)|FD-Score:3.31|P-value:4.62E-4|Clearance:0.01||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans Gene:TAD3(YLR316C)|FD-Score:-3.31|P-value:4.71E-4|Clearance:0||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs Gene:TIM54(YJL054W)|FD-Score:-3.19|P-value:7.18E-4|Clearance:0||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane Gene:PRI2(YKL045W)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.26||SGD DESC:Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair Gene:RPP1(YHR062C)|FD-Score:5.14|P-value:1.35E-7|Clearance:0.08||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC13(YLR208W)|FD-Score:22.2|P-value:8.80E-110|Clearance:17.09||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SEC31(YDL195W)|FD-Score:5.06|P-value:2.10E-7|Clearance:1.75||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SYF1(YDR416W)|FD-Score:3.31|P-value:4.62E-4|Clearance:0.01||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans Gene:TAD3(YLR316C)|FD-Score:-3.31|P-value:4.71E-4|Clearance:0||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs Gene:TIM54(YJL054W)|FD-Score:-3.19|P-value:7.18E-4|Clearance:0||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 773758
Download HOP data (tab-delimited text)  (excel)
Gene:ALG6(YOR002W)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ARP1(YHR129C)|FD-Score:3.24|P-value:5.91E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:CCW12(YLR110C)|FD-Score:3.14|P-value:8.55E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:COA1(YIL157C)|FD-Score:3.74|P-value:9.34E-5||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:DAL81(YIR023W)|FD-Score:5.21|P-value:9.39E-8||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:ERD1(YDR414C)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) Gene:GCN4(YEL009C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GLG2(YJL137C)|FD-Score:3.8|P-value:7.30E-5||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:GLY1(YEL046C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis Gene:GUD1(YDL238C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures Gene:GUT1(YHL032C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:HXT2(YMR011W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:KTR7(YIL085C)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication Gene:LEM3(YNL323W)|FD-Score:3.11|P-value:9.44E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MDM31(YHR194W)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MMT1(YMR177W)|FD-Score:-3.15|P-value:8.18E-4||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p Gene:NIT1(YIL164C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTC20(YBR188C)|FD-Score:3.83|P-value:6.32E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:NTH2(YBR001C)|FD-Score:3.76|P-value:8.40E-5||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:OPY1(YBR129C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:OSW2(YLR054C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PEX15(YOL044W)|FD-Score:4.05|P-value:2.56E-5||SGD DESC:Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly Gene:PEX32(YBR168W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:PHO88(YBR106W)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:POM34(YLR018C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication Gene:SNT309(YPR101W)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPP1(YPL138C)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SSO1(YPL232W)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p Gene:STO1(YMR125W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 Gene:STP1(YDR463W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:STV1(YMR054W)|FD-Score:3.33|P-value:4.42E-4||SGD DESC:Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole Gene:TAT1(YBR069C)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:UBI4(YLL039C)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UBP11(YKR098C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:VMA22(YHR060W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) Gene:VPS55(YJR044C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) Gene:YAR047C(YAR047C_d)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCH1(YGR203W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YDL242W(YDL242W_d)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR239C(YDR239C)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YIR020C(YIR020C_p)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YLR365W(YLR365W_d)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene Gene:YML020W(YML020W_p)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:Putative protein of unknown function Gene:YMR262W(YMR262W_p)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YND1(YER005W)|FD-Score:3.1|P-value:9.67E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL092W(YNL092W_p)|FD-Score:-3.96|P-value:3.76E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene Gene:YOL050C(YOL050C_d)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YPR084W(YPR084W_p)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Putative protein of unknown function Gene:YPS5(YGL259W_p)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p Gene:ALG6(YOR002W)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ARP1(YHR129C)|FD-Score:3.24|P-value:5.91E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:CCW12(YLR110C)|FD-Score:3.14|P-value:8.55E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:COA1(YIL157C)|FD-Score:3.74|P-value:9.34E-5||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:DAL81(YIR023W)|FD-Score:5.21|P-value:9.39E-8||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:ERD1(YDR414C)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) Gene:GCN4(YEL009C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GLG2(YJL137C)|FD-Score:3.8|P-value:7.30E-5||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:GLY1(YEL046C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis Gene:GUD1(YDL238C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures Gene:GUT1(YHL032C)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:HXT2(YMR011W)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:KTR7(YIL085C)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication Gene:LEM3(YNL323W)|FD-Score:3.11|P-value:9.44E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MDM31(YHR194W)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MMT1(YMR177W)|FD-Score:-3.15|P-value:8.18E-4||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p Gene:NIT1(YIL164C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTC20(YBR188C)|FD-Score:3.83|P-value:6.32E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:NTH2(YBR001C)|FD-Score:3.76|P-value:8.40E-5||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:OPY1(YBR129C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:OSW2(YLR054C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PEX15(YOL044W)|FD-Score:4.05|P-value:2.56E-5||SGD DESC:Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly Gene:PEX32(YBR168W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:PHO88(YBR106W)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:POM34(YLR018C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication Gene:SNT309(YPR101W)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPP1(YPL138C)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SSO1(YPL232W)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p Gene:STO1(YMR125W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 Gene:STP1(YDR463W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:STV1(YMR054W)|FD-Score:3.33|P-value:4.42E-4||SGD DESC:Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole Gene:TAT1(YBR069C)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:UBI4(YLL039C)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UBP11(YKR098C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:VMA22(YHR060W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) Gene:VPS55(YJR044C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) Gene:YAR047C(YAR047C_d)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCH1(YGR203W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YDL242W(YDL242W_d)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR239C(YDR239C)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YIR020C(YIR020C_p)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YLR365W(YLR365W_d)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene Gene:YML020W(YML020W_p)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:Putative protein of unknown function Gene:YMR262W(YMR262W_p)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YND1(YER005W)|FD-Score:3.1|P-value:9.67E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL092W(YNL092W_p)|FD-Score:-3.96|P-value:3.76E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene Gene:YOL050C(YOL050C_d)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YPR084W(YPR084W_p)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Putative protein of unknown function Gene:YPS5(YGL259W_p)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR208W22.208.80E-11017.10SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YHR062C5.141.35E-70.08RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDL195W5.062.10E-71.75SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YDR416W3.314.62E-40.01SYF1Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
YKL045W3.304.78E-40.26PRI2Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YDL150W3.040.001180.07RPC53RNA polymerase III subunit C53
YDR381W2.970.001500.02YRA1RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
YBL077W_d2.950.001590.02YBL077W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YIL109C2.930.001690.01SEC24Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
YDR407C2.920.001740.01TRS120One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YPR094W2.920.001770.05RDS3Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
YOR326W2.860.002100.04MYO2Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication
YPR133C2.820.002390.03SPN1Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
YOL133W2.790.002640.13HRT1RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
YDR246W2.660.003960.03TRS23One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIR023W5.219.39E-8DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YLL039C4.721.19E-6UBI4Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
YOR002W4.464.13E-6ALG6Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YML020W_p4.415.12E-6YML020W_pPutative protein of unknown function
YBR069C4.221.24E-5TAT1Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress
YEL046C4.171.55E-5GLY1Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YOL044W4.052.56E-5PEX15Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
YMR125W4.013.04E-5STO1Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YDR414C3.944.04E-5ERD1Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YPR101W3.846.06E-5SNT309Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YBR188C3.836.32E-5NTC20Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YAR047C_d3.836.36E-5YAR047C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL137C3.807.30E-5GLG2Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
YPL232W3.797.43E-5SSO1Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
YBR001C3.768.40E-5NTH2Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_290
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.5250SGTC_20255147754 141.0 μMChembridge (Fragment library)3157770.106061
0.4790SGTC_1743st037606 46.4 μMTimTec (Natural product derivative library)5901420.0675676
0.4398.00E-277SGTC_14204'-methoxyflavone 42.0 μMChemDiv (Drug-like library)777930.0909091
0.4301.10E-264SGTC_32009114385 49.5 μMChembridge (Drug-like library)170180300.136364
0.3972.76E-222SGTC_7864544-0069 423.0 μMChemDiv (Drug-like library)7488210.145161
0.3863.51E-209SGTC_14163966-0321 25.3 μMChemDiv (Drug-like library)5825300.116667
0.3297.65E-149SGTC_1655st012546 55.1 μMTimTec (Natural product derivative library)7209850.0909091
0.3178.00E-138SGTC_9933909-8757 62.7 μMChemDiv (Drug-like library)42883240.0704225
0.2881.88E-113SGTC_7234182-0001 115.0 μMChemDiv (Drug-like library)7448210.057971
0.2631.20E-93SGTC_592k241-0073 46.5 μMChemDiv (Drug-like library)42301580.142857
0.2622.31E-93SGTC_890302-0250 142.1 μMChemDiv (Drug-like library)42035180.0461538
0.2592.06E-91SGTC_31979113331 49.5 μMChembridge (Drug-like library)166104590.0963855
0.2537.48E-87SGTC_1772st048439 82.2 μMTimTec (Natural product derivative library)29270680.0724638
0.2402.12E-78SGTC_8780828-0289 13.7 μMChemDiv (Drug-like library)7453500.112676
0.2321.12E-72SGTC_10044084-0029 199.0 μMChemDiv (Drug-like library)7168940.114286

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8600443-001625.1 μM0.45337942ChemDiv (Drug-like library)242.2450433.66513
SGTC_1604st00205272.4 μM0.3846156254834TimTec (Natural product derivative library)276.3043234.81502TSC3-RPN4
SGTC_2045510665278.05 μM0.358491673349Chembridge (Fragment library)213.231942.2902
SGTC_23117694451200 μM0.3518522163142Chembridge (Fragment library)205.2531.31602
SGTC_10204335-096193.3 μM0.327586669075ChemDiv (Drug-like library)267.322382.91302
SGTC_22837944793200 μM0.3275862970533Chembridge (Fragment library)228.246581.92303
SGTC_3172910586349.47 μM0.303032348785Chembridge (Drug-like library)389.414093.80806ERG2
SGTC_2795778001054.55 μM0.295082953673Chembridge (Drug-like library)312.3812434.15113
SGTC_1608st00147340.5 μM0.2941187292267TimTec (Natural product derivative library)242.700244.36601
SGTC_3056909490049.47 μM0.28571425236784Chembridge (Drug-like library)342.4072233.88404