5-(ethoxymethyl)quinolin-8-ol

5-(ethoxymethyl)quinolin-8-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2901
Screen concentration 39.7 μM
Source Chembridge (Drug-like library)
PubChem CID 279621
SMILES CCOCC1=C2C=CC=NC2=C(C=C1)O
Standardized SMILES CCOCc1ccc(O)c2ncccc12
Molecular weight 203.2371
ALogP 1.93
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.88
% growth inhibition (Hom. pool) 4.21


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 279621
Download HIP data (tab-delimited text)  (excel)
Gene:CHS2(YBR038W)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.32||SGD DESC:Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis Gene:RPT3(YDR394W)|FD-Score:3.11|P-value:9.23E-4|Clearance:0.05||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B Gene:RSC58(YLR033W)|FD-Score:3.83|P-value:6.44E-5|Clearance:0.37||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:TAD3(YLR316C)|FD-Score:3.46|P-value:2.74E-4|Clearance:0.03||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs Gene:CHS2(YBR038W)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.32||SGD DESC:Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis Gene:RPT3(YDR394W)|FD-Score:3.11|P-value:9.23E-4|Clearance:0.05||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B Gene:RSC58(YLR033W)|FD-Score:3.83|P-value:6.44E-5|Clearance:0.37||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:TAD3(YLR316C)|FD-Score:3.46|P-value:2.74E-4|Clearance:0.03||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 279621
Download HOP data (tab-delimited text)  (excel)
Gene:CAP1(YKL007W)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CKA1(YIL035C)|FD-Score:4.37|P-value:6.09E-6||SGD DESC:Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching Gene:COX8(YLR395C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CPA1(YOR303W)|FD-Score:-3.55|P-value:1.93E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:DIF1(YLR437C)|FD-Score:-3.13|P-value:8.86E-4||SGD DESC:Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein Gene:ERP1(YAR002C-A)|FD-Score:-3.28|P-value:5.25E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:HSP31(YDR533C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:KDX1(YKL161C)|FD-Score:3.31|P-value:4.75E-4||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:KTR7(YIL085C)|FD-Score:-6.09|P-value:5.65E-10||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication Gene:PUT2(YHR037W)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:TDH1(YJL052W)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TYE7(YOR344C)|FD-Score:-3.24|P-value:5.92E-4||SGD DESC:Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression Gene:VPS17(YOR132W)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes Gene:YDL071C(YDL071C_d)|FD-Score:5.36|P-value:4.21E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Gene:YDR154C(YDR154C_d)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR366W(YLR366W_d)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YPR014C(YPR014C_d)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Gene:CAP1(YKL007W)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CKA1(YIL035C)|FD-Score:4.37|P-value:6.09E-6||SGD DESC:Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching Gene:COX8(YLR395C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CPA1(YOR303W)|FD-Score:-3.55|P-value:1.93E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:DIF1(YLR437C)|FD-Score:-3.13|P-value:8.86E-4||SGD DESC:Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein Gene:ERP1(YAR002C-A)|FD-Score:-3.28|P-value:5.25E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:HSP31(YDR533C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:KDX1(YKL161C)|FD-Score:3.31|P-value:4.75E-4||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:KTR7(YIL085C)|FD-Score:-6.09|P-value:5.65E-10||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication Gene:PUT2(YHR037W)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:TDH1(YJL052W)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TYE7(YOR344C)|FD-Score:-3.24|P-value:5.92E-4||SGD DESC:Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression Gene:VPS17(YOR132W)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes Gene:YDL071C(YDL071C_d)|FD-Score:5.36|P-value:4.21E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Gene:YDR154C(YDR154C_d)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR366W(YLR366W_d)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YPR014C(YPR014C_d)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR033W3.836.44E-50.37RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YLR316C3.462.74E-40.03TAD3Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
YBR038W3.433.01E-40.32CHS2Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis
YDR394W3.119.23E-40.05RPT3One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YGR046W3.060.001110.06TAM41Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
YKR022C3.000.001370.14NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YPR082C2.860.002130.05DIB117-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
YGL238W2.810.002510.10CSE1Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YKL104C2.710.003370.02GFA1Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
YGR253C2.690.003580.06PUP2Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YKR062W2.630.004330.00TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YOR362C2.620.004350.01PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YDR177W2.620.004460.04UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YBL084C2.580.004940.01CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YMR203W2.570.005130.02TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL071C_d5.364.21E-8YDL071C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W
YIL035C4.376.09E-6CKA1Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
YOR132W3.894.95E-5VPS17Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
YLR395C3.701.08E-4COX8Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YLR366W_d3.601.60E-4YLR366W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YHR037W3.502.36E-4PUT2Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YJL052W3.393.49E-4TDH1Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
YKL161C3.314.75E-4KDX1Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
YFL041W-A_p3.275.40E-4YFL041W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YDR533C3.197.02E-4HSP31Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
YBR159W3.040.00119IFA38Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YGR121C3.020.00126MEP1Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YAL012W3.010.00131CYS3Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
YJL103C2.970.00147GSM1Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YBR246W2.970.00151RRT2Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription

GO enrichment analysis for SGTC_2901
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1322.20E-24SGTC_29035923464 63.9 μMChembridge (Drug-like library)28765760.153846
0.1064.59E-16SGTC_29047225135 42.0 μMChembridge (Drug-like library)44461160.126761
0.0992.28E-14SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.106061RSC & ERG11
0.0936.71E-13SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.0724638RSC & ERG11
0.0913.42E-12SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0909091RSC complex & mRNA processing
0.0904.45E-12SGTC_1992st073643 23.3 μMTimTec (Natural product derivative library)31612920.0857143mitochondrial processes
0.0881.53E-11SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0434783RSC complex & mRNA processing
0.0823.44E-10SGTC_7093807-1509 243.0 μMChemDiv (Drug-like library)18866770.0434783RSC complex & mRNA processing
0.0809.87E-10SGTC_29117942208 15.6 μMChembridge (Drug-like library)12433840.109375mitochondrial response to ROS
0.0782.12E-9SGTC_1771327-0068 8.4 μMChemDiv (Drug-like library)153899000.0967742
0.0773.41E-9SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.0921053RSC & ERG11
0.0714.64E-8SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.121212RSC complex & mRNA processing
0.0706.52E-8SGTC_421streptovitacin 30.0 mMMiscellaneous914670.0597015
0.0706.65E-8SGTC_509pifithrin 175.0 μMICCB bioactive library48170.0746269mitochondrial processes
0.0672.26E-7SGTC_3241315-0088 19.6 μMChemDiv (Drug-like library)67874210.101449RSC & ERG11

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_21695-(ethoxymethyl)quinolin-8-ol49.51 μM1279621Chembridge (Fragment library)203.237121.92713
SGTC_2115tiliquinol12.77 μM0.52631671208Chembridge (Fragment library)159.184562.2612
SGTC_1962st07659564.5 μM0.511111279619TimTec (Natural product derivative library)242.316222.76513redox potentiating
SGTC_2784756767372.73 μM0.3396233471247Chembridge (Drug-like library)343.42011.29616iron homeostasis
SGTC_2116551145216.88 μM0.325581870744Chembridge (Fragment library)161.157381.53223
SGTC_1637st00792417.4 μM0.310345683336TimTec (Natural product derivative library)290.787863.68113
SGTC_1640st00907866.4 μM0.306452690618TimTec (Natural product derivative library)301.340362.91115
SGTC_23217390090138.78 μM0.288462649046Chembridge (Fragment library)214.263062.85423
SGTC_6790422-009141.4 μM0.282609627384ChemDiv (Drug-like library)301.965342.76612Golgi
SGTC_13963511-000798.6 μM0.268657X1396ChemDiv (Drug-like library)421.843265.08441mitochondrial processes