5923464

1-(benzimidazol-1-yl)-3-(4-propan-2-ylphenoxy)propan-2-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2903
Screen concentration 63.9 μM
Source Chembridge (Drug-like library)
PubChem CID 2876576
SMILES CC(C)C1=CC=C(C=C1)OCC(CN2C=NC3=CC=CC=C32)O
Standardized SMILES CC(C)c1ccc(OCC(O)Cn2cnc3ccccc23)cc1
Molecular weight 310.3902
ALogP 3.87
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.36
% growth inhibition (Hom. pool) 8.66


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2876576
Download HIP data (tab-delimited text)  (excel)
Gene:GRS1(YBR121C)|FD-Score:-3.39|P-value:3.54E-4|Clearance:0||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:RAP1(YNL216W)|FD-Score:-3.68|P-value:1.14E-4|Clearance:0||SGD DESC:Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) Gene:RPB5(YBR154C)|FD-Score:4.55|P-value:2.67E-6|Clearance:0.85||SGD DESC:RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation Gene:RPL10(YLR075W)|FD-Score:3.7|P-value:1.10E-4|Clearance:0.39||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:SNM1(YDR478W)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.32||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP Gene:GRS1(YBR121C)|FD-Score:-3.39|P-value:3.54E-4|Clearance:0||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:RAP1(YNL216W)|FD-Score:-3.68|P-value:1.14E-4|Clearance:0||SGD DESC:Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) Gene:RPB5(YBR154C)|FD-Score:4.55|P-value:2.67E-6|Clearance:0.85||SGD DESC:RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation Gene:RPL10(YLR075W)|FD-Score:3.7|P-value:1.10E-4|Clearance:0.39||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:SNM1(YDR478W)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.32||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2876576
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ARG81(YML099C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p Gene:ARP6(YLR085C)|FD-Score:3.93|P-value:4.29E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:CPA1(YOR303W)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:ECM5(YMR176W)|FD-Score:-3.15|P-value:8.30E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:ERP1(YAR002C-A)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:EST2(YLR318W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia Gene:FUN14(YAL008W)|FD-Score:4.03|P-value:2.83E-5||SGD DESC:Mitochondrial protein of unknown function Gene:GCN20(YFR009W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GDA1(YEL042W)|FD-Score:-3.19|P-value:7.16E-4||SGD DESC:Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate Gene:HTZ1(YOL012C)|FD-Score:4.58|P-value:2.37E-6||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:LYS1(YIR034C)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity Gene:MBP1(YDL056W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MRP8(YKL142W)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MRPL32(YCR003W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:PRC1(YMR297W)|FD-Score:-4.07|P-value:2.32E-5||SGD DESC:Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family Gene:RMD5(YDR255C)|FD-Score:-3.77|P-value:8.29E-5||SGD DESC:Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain Gene:RPL29(YFR032C-A)|FD-Score:4.02|P-value:2.85E-5||SGD DESC:Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog Gene:RSM25(YIL093C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SCT1(YBL011W)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SEC72(YLR292C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SEY1(YOR165W)|FD-Score:3.14|P-value:8.53E-4||SGD DESC:Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 Gene:TEA1(YOR337W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:THI2(YBR240C)|FD-Score:3.8|P-value:7.19E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:TPM1(YNL079C)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication Gene:YCK3(YER123W)|FD-Score:5.05|P-value:2.17E-7||SGD DESC:Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway Gene:YET3(YDL072C)|FD-Score:-4.27|P-value:9.87E-6||SGD DESC:Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress Gene:YFL041W-A(YFL041W-A_p)|FD-Score:5.56|P-value:1.34E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR126W(YGR126W_p)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YKR047W(YKR047W_d)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YLR271W(YLR271W_p)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR287C(YLR287C_p)|FD-Score:-3.82|P-value:6.73E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YMR242W-A(YMR242W-A_p)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Putative protein of unknown function Gene:YOR131C(YOR131C_p)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress Gene:YPR014C(YPR014C_d)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Gene:ACE2(YLR131C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:ARG81(YML099C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p Gene:ARP6(YLR085C)|FD-Score:3.93|P-value:4.29E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:CPA1(YOR303W)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:ECM5(YMR176W)|FD-Score:-3.15|P-value:8.30E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:ERP1(YAR002C-A)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:EST2(YLR318W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia Gene:FUN14(YAL008W)|FD-Score:4.03|P-value:2.83E-5||SGD DESC:Mitochondrial protein of unknown function Gene:GCN20(YFR009W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GDA1(YEL042W)|FD-Score:-3.19|P-value:7.16E-4||SGD DESC:Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate Gene:HTZ1(YOL012C)|FD-Score:4.58|P-value:2.37E-6||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:LYS1(YIR034C)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity Gene:MBP1(YDL056W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MRP8(YKL142W)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MRPL32(YCR003W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:PRC1(YMR297W)|FD-Score:-4.07|P-value:2.32E-5||SGD DESC:Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family Gene:RMD5(YDR255C)|FD-Score:-3.77|P-value:8.29E-5||SGD DESC:Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain Gene:RPL29(YFR032C-A)|FD-Score:4.02|P-value:2.85E-5||SGD DESC:Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog Gene:RSM25(YIL093C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SCT1(YBL011W)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SEC72(YLR292C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SEY1(YOR165W)|FD-Score:3.14|P-value:8.53E-4||SGD DESC:Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 Gene:TEA1(YOR337W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:THI2(YBR240C)|FD-Score:3.8|P-value:7.19E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:TPM1(YNL079C)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication Gene:YCK3(YER123W)|FD-Score:5.05|P-value:2.17E-7||SGD DESC:Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway Gene:YET3(YDL072C)|FD-Score:-4.27|P-value:9.87E-6||SGD DESC:Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress Gene:YFL041W-A(YFL041W-A_p)|FD-Score:5.56|P-value:1.34E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR126W(YGR126W_p)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YKR047W(YKR047W_d)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YLR271W(YLR271W_p)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR287C(YLR287C_p)|FD-Score:-3.82|P-value:6.73E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YMR242W-A(YMR242W-A_p)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Putative protein of unknown function Gene:YOR131C(YOR131C_p)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress Gene:YPR014C(YPR014C_d)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR154C4.552.67E-60.85RPB5RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YLR075W3.701.10E-40.39RPL10Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
YDR478W3.314.66E-40.32SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YHR007C2.990.001370.03ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YBR140C2.960.001520.15IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YMR033W2.820.002410.04ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YJR042W2.770.002760.05NUP85Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
YPL169C2.720.003250.06MEX67Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
YDL102W2.660.003950.05POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YPR187W2.600.004600.07RPO26RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YDL153C2.540.005580.02SAS10Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
YDL087C2.520.005890.02LUC7Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
YKL145W2.500.006280.01RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YOR206W2.480.006540.00NOC2Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YFR002W2.480.006570.01NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFL041W-A_p5.561.34E-8YFL041W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YER123W5.052.17E-7YCK3Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
YFR009W4.681.44E-6GCN20Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YOL012C4.582.37E-6HTZ1Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YLR131C4.201.35E-5ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YAL008W4.032.83E-5FUN14Mitochondrial protein of unknown function
YFR032C-A4.022.85E-5RPL29Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
YLR085C3.934.29E-5ARP6Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YLR271W_p3.895.00E-5YLR271W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YBR240C3.807.19E-5THI2Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YML099C3.711.02E-4ARG81Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
YLR292C3.691.11E-4SEC72Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YCR003W3.671.20E-4MRPL32Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
YOR337W3.502.29E-4TEA1Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
YLR318W3.462.67E-4EST2Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia

GO enrichment analysis for SGTC_2903
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1322.20E-24SGTC_29015-(ethoxymethyl)quinolin-8-ol 39.7 μMChembridge (Drug-like library)2796210.153846
0.1156.76E-19SGTC_225nsc-122657 1.0 μMMiscellaneous2756850.0857143
0.1127.53E-18SGTC_1603453-0671 289.7 μMChemDiv (Drug-like library)53222680.0888889
0.0912.09E-12SGTC_30069075424 71.4 μMChembridge (Drug-like library)74651810.0789474
0.0791.10E-9SGTC_33169136639 10.5 μMChembridge (Drug-like library)49036650.109756
0.0791.38E-9SGTC_223busulfan 5.0 mMMiscellaneous24780.0555556
0.0774.23E-9SGTC_220paclitaxel 373.4 μMMiscellaneous46660.0932203
0.0759.31E-9SGTC_9721319-0219 195.0 μMChemDiv (Drug-like library)239037020.134831
0.0741.23E-8SGTC_21765809774 34.0 μMChembridge (Fragment library)28705390.0769231mitochondrial processes
0.0731.73E-8SGTC_21615662504 8.5 μMChembridge (Fragment library)28593340.0746269tubulin folding & SWR complex
0.0723.24E-8SGTC_6770929-0063 136.0 μMChemDiv (Drug-like library)15395830.0704225
0.0714.13E-8SGTC_13261431-2094 10.8 μMChemDiv (Drug-like library)6162780.145161tubulin folding & SWR complex
0.0691.33E-7SGTC_222nsc-310342 10.7 μMMiscellaneous4325560.0684932
0.0681.60E-7SGTC_5831488-1091 88.9 μMChemDiv (Drug-like library)43032730.0540541
0.0641.05E-6SGTC_224benfluorex 43.9 μMMiscellaneous23180.128205

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_7243910-0327137 μM0.4736842885483ChemDiv (Drug-like library)316.782083.59813ERG2
SGTC_2803770726371.43 μM0.4629632199229Chembridge (Drug-like library)282.337023.22903
SGTC_5623772-2733112 μM0.4576272876874ChemDiv (Drug-like library)422.260134.17813ERG2
SGTC_3234013-090634.3 μM0.4029852910086ChemDiv (Drug-like library)348.438164.22413ERG2
SGTC_14133910-053534.4 μM0.3787882876951ChemDiv (Drug-like library)358.861825.21313
SGTC_13702001-009244.6 μM0.375790957ChemDiv (Drug-like library)256.2749233.38903
SGTC_2906792629226.41 μM0.3620692966319Chembridge (Drug-like library)331.20713.99402
SGTC_9943910-0338138 μM0.3333333479481ChemDiv (Drug-like library)425.318345.25713calcium & mitochondrial duress
SGTC_3304912567846.09 μM0.312541316246Chembridge (Drug-like library)281.352262.74602
SGTC_10084106-00376 μM0.2941182905394ChemDiv (Drug-like library)443.580525.23214PDR1