k038-0015

N-[4-(1-adamantyl)phenyl]-1-[5-chloro-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methanimine

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_292
Screen concentration 474.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 46368540
SMILES CN1C(=C(C(=N1)C(F)(F)F)C=NC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4)Cl
Standardized SMILES Cn1nc(c(C=Nc2ccc(cc2)C34CC5CC(CC(C5)C3)C4)c1Cl)C(F)(F)F
Molecular weight 421.8863
ALogP 6.32
H-bond donor count 0
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.4
% growth inhibition (Hom. pool) 1.12


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 46368540
Download HIP data (tab-delimited text)  (excel)
Gene:BCD1(YHR040W)|FD-Score:5.86|P-value:2.29E-9|Clearance:1.57||SGD DESC:Essential protein required for the accumulation of box C/D snoRNA Gene:GCD6(YDR211W)|FD-Score:3.42|P-value:3.17E-4|Clearance:0.13||SGD DESC:Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress Gene:RPC53(YDL150W)|FD-Score:3.17|P-value:7.57E-4|Clearance:0.04||SGD DESC:RNA polymerase III subunit C53 Gene:RPL15A(YLR029C)|FD-Score:3.28|P-value:5.13E-4|Clearance:0.11||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:TPI1(YDR050C)|FD-Score:3.13|P-value:8.71E-4|Clearance:0.26||SGD DESC:Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease Gene:YGL074C(YGL074C_d)|FD-Score:-4.77|P-value:9.10E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor Gene:YIF1(YNL263C)|FD-Score:3.46|P-value:2.70E-4|Clearance:0.04||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 Gene:YRA1(YDR381W)|FD-Score:5.03|P-value:2.46E-7|Clearance:1.57||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member Gene:BCD1(YHR040W)|FD-Score:5.86|P-value:2.29E-9|Clearance:1.57||SGD DESC:Essential protein required for the accumulation of box C/D snoRNA Gene:GCD6(YDR211W)|FD-Score:3.42|P-value:3.17E-4|Clearance:0.13||SGD DESC:Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress Gene:RPC53(YDL150W)|FD-Score:3.17|P-value:7.57E-4|Clearance:0.04||SGD DESC:RNA polymerase III subunit C53 Gene:RPL15A(YLR029C)|FD-Score:3.28|P-value:5.13E-4|Clearance:0.11||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:TPI1(YDR050C)|FD-Score:3.13|P-value:8.71E-4|Clearance:0.26||SGD DESC:Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease Gene:YGL074C(YGL074C_d)|FD-Score:-4.77|P-value:9.10E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor Gene:YIF1(YNL263C)|FD-Score:3.46|P-value:2.70E-4|Clearance:0.04||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 Gene:YRA1(YDR381W)|FD-Score:5.03|P-value:2.46E-7|Clearance:1.57||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 46368540
Download HOP data (tab-delimited text)  (excel)
Gene:BUD9(YGR041W)|FD-Score:4.74|P-value:1.06E-6||SGD DESC:Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole Gene:CBC2(YPL178W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif Gene:DCI1(YOR180C)|FD-Score:3.14|P-value:8.46E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:FRE6(YLL051C)|FD-Score:-4.28|P-value:9.22E-6||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:ICS2(YBR157C)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization Gene:IRC21(YMR073C)|FD-Score:4.08|P-value:2.24E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:IST1(YNL265C)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p Gene:LYS12(YIL094C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MPA43(YNL249C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MSB3(YNL293W)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MTC7(YEL033W_p)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:NIS1(YNL078W)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:PCL1(YNL289W)|FD-Score:-3.94|P-value:4.04E-5||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PDE1(YGL248W)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PMP2(YEL017C-A)|FD-Score:3.42|P-value:3.10E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PMT7(YDR307W_p)|FD-Score:3.75|P-value:8.82E-5||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:PRE9(YGR135W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:PTP1(YDL230W)|FD-Score:-3.12|P-value:9.12E-4||SGD DESC:Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation Gene:RGL1(YPL066W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:RPS16B(YDL083C)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication Gene:RSM25(YIL093C)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SSK2(YNR031C)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STR3(YGL184C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p Gene:TDH3(YGR192C)|FD-Score:-4.79|P-value:8.22E-7||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication Gene:VBA1(YMR088C)|FD-Score:3.78|P-value:7.94E-5||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YAR028W(YAR028W_p)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YBR016W(YBR016W)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication Gene:YBR221W-A(YBR221W-A_p)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YCL001W-A(YCL001W-A_p)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III Gene:YCR006C(YCR006C_d)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL043W(YJL043W_p)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Putative protein of unknown function; YJL043W is a non-essential gene Gene:YLR217W(YLR217W_d)|FD-Score:3.75|P-value:8.90E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Gene:YMR320W(YMR320W_d)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOR289W(YOR289W_p)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:BUD9(YGR041W)|FD-Score:4.74|P-value:1.06E-6||SGD DESC:Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole Gene:CBC2(YPL178W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif Gene:DCI1(YOR180C)|FD-Score:3.14|P-value:8.46E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:FRE6(YLL051C)|FD-Score:-4.28|P-value:9.22E-6||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:ICS2(YBR157C)|FD-Score:4.05|P-value:2.51E-5||SGD DESC:Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization Gene:IRC21(YMR073C)|FD-Score:4.08|P-value:2.24E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:IST1(YNL265C)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p Gene:LYS12(YIL094C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MPA43(YNL249C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MSB3(YNL293W)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MTC7(YEL033W_p)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:NIS1(YNL078W)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:PCL1(YNL289W)|FD-Score:-3.94|P-value:4.04E-5||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PDE1(YGL248W)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PMP2(YEL017C-A)|FD-Score:3.42|P-value:3.10E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PMT7(YDR307W_p)|FD-Score:3.75|P-value:8.82E-5||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:PRE9(YGR135W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:PTP1(YDL230W)|FD-Score:-3.12|P-value:9.12E-4||SGD DESC:Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation Gene:RGL1(YPL066W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:RPS16B(YDL083C)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication Gene:RSM25(YIL093C)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SSK2(YNR031C)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STR3(YGL184C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p Gene:TDH3(YGR192C)|FD-Score:-4.79|P-value:8.22E-7||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication Gene:VBA1(YMR088C)|FD-Score:3.78|P-value:7.94E-5||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YAR028W(YAR028W_p)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YBR016W(YBR016W)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication Gene:YBR221W-A(YBR221W-A_p)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YCL001W-A(YCL001W-A_p)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III Gene:YCR006C(YCR006C_d)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL043W(YJL043W_p)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Putative protein of unknown function; YJL043W is a non-essential gene Gene:YLR217W(YLR217W_d)|FD-Score:3.75|P-value:8.90E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Gene:YMR320W(YMR320W_d)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOR289W(YOR289W_p)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR040W5.862.29E-91.57BCD1Essential protein required for the accumulation of box C/D snoRNA
YDR381W5.032.46E-71.57YRA1RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
YNL263C3.462.70E-40.04YIF1Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
YDR211W3.423.17E-40.13GCD6Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
YLR029C3.285.13E-40.11RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YDL150W3.177.57E-40.04RPC53RNA polymerase III subunit C53
YDR050C3.138.71E-40.26TPI1Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
YBL077W_d2.870.002050.07YBL077W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YMR277W2.800.002550.12FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YOR181W2.680.003710.01LAS17Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YOR319W2.670.003790.02HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YOL038W2.650.003990.03PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YLL011W2.620.004410.01SOF1Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YBR152W2.610.004580.02SPP381mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
YDR302W2.580.004897.18E-4GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR041W4.741.06E-6BUD9Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YGR135W4.631.83E-6PRE9Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
YBR221W-A_p4.201.36E-5YBR221W-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YNL249C4.191.38E-5MPA43Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR073C4.082.24E-5IRC21Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
YBR157C4.052.51E-5ICS2Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YNR031C3.797.56E-5SSK2MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
YMR088C3.787.94E-5VBA1Permease of basic amino acids in the vacuolar membrane
YDR307W_p3.758.82E-5PMT7_pPutative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
YLR217W_d3.758.90E-5YLR217W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YGL184C3.452.84E-4STR3Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
YEL017C-A3.423.10E-4PMP2Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
YIL002W-A_p3.423.12E-4YIL002W-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YPL178W3.403.35E-4CBC2Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YEL033W_p3.334.29E-4MTC7_pPredicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant

GO enrichment analysis for SGTC_292
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0552.36E-5SGTC_22157188065 200.0 μMChembridge (Fragment library)9402170.107692
0.0543.31E-5SGTC_1814st052110 31.5 μMTimTec (Natural product derivative library)6741630.0632911RNA processing & uracil transport
0.0535.38E-5SGTC_27957780010 54.5 μMChembridge (Drug-like library)9536730.0875
0.0501.15E-4SGTC_2612dictamnine 15.5 μMMicrosource (Natural product library)680850.0694444RNA pol III & RNase P/MRP
0.0491.49E-4SGTC_1104tacrolimus 29.8 μMNIH Clinical Collection235817960.0615385
0.0482.42E-4SGTC_20405100729 123.0 μMChembridge (Fragment library)118400.0597015
0.0473.29E-4SGTC_2412st077135 33.4 μMTimTec (Natural product derivative library)132589150.049505
0.0454.91E-4SGTC_23939031399 185.9 μMChembridge (Fragment library)15266230.0533333RNA processing & uracil transport
0.0420.00114SGTC_1840st055363 71.0 μMTimTec (Natural product derivative library)6760330.0512821
0.0410.00175SGTC_1910st062352 60.4 μMTimTec (Natural product derivative library)22457300.0555556
0.0410.00183SGTC_3542783-3500 4.9 μMChemDiv (Drug-like library)67407610.0649351cell wall
0.0400.00188SGTC_710417-1750 47.8 μMChemDiv (Drug-like library)68114720.146341Golgi
0.0380.00324SGTC_20064011487 200.0 μMChembridge (Fragment library)455952940.0441176endomembrane recycling
0.0380.00374SGTC_9383126-1755 342.0 μMChemDiv (Drug-like library)17777710.0506329
0.0380.00410SGTC_3720155-0182 15.9 μMChemDiv (Drug-like library)7714860.0694444mitochondrial response to ROS

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_165k038-002364.38 μM0.49152546368543ChemDiv (Drug-like library)383.449276.77804ubiquinone biosynthesis & proteasome
SGTC_216k038-003528.38 μM0.4727274444231ChemDiv (Drug-like library)316.439364.68502ubiquinone biosynthesis & proteasome
SGTC_200k038-007937.55 μM0.4406783436683ChemDiv (Drug-like library)316.439364.68502ubiquinone biosynthesis & proteasome
SGTC_294k038-0071157 μM0.44067824152826ChemDiv (Drug-like library)335.50566.27502ubiquinone biosynthesis & proteasome
SGTC_8460335-0850148 μM0.4310346819598ChemDiv (Drug-like library)331.45074.50912ubiquinone biosynthesis & proteasome
SGTC_794k038-0031316 μM0.4193556624242ChemDiv (Drug-like library)405.529245.78604ubiquinone biosynthesis & proteasome
SGTC_670335-0847266 μM0.4126984552207ChemDiv (Drug-like library)375.503265.80303ubiquinone biosynthesis & proteasome
SGTC_340k038-0059454 μM0.40983623733424ChemDiv (Drug-like library)400.375086.53702ubiquinone biosynthesis & proteasome
SGTC_158k038-008726.45 μM0.396825X158ChemDiv (Drug-like library)354.487346.12911ubiquinone biosynthesis & proteasome
SGTC_860417-1630471.92 μM0.3939393634867ChemDiv (Drug-like library)401.58367.402ubiquinone biosynthesis & proteasome