9011802

5-bromo-3-(thiophen-2-ylmethyl)-1,3-dihydroindol-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2927
Screen concentration 47.9 μM
Source Chembridge (Drug-like library)
PubChem CID 43912568
SMILES C1=CSC(=C1)CC2C3=C(C=CC(=C3)Br)NC2=O
Standardized SMILES Brc1ccc2NC(=O)C(Cc3cccs3)c2c1
Molecular weight 308.1936
ALogP 3.05
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.52
% growth inhibition (Hom. pool) 6.43


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 43912568
Download HIP data (tab-delimited text)  (excel)
Gene:BBP1(YPL255W)|FD-Score:-3.37|P-value:3.75E-4|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:FMN1(YDR236C)|FD-Score:-5.33|P-value:4.84E-8|Clearance:0||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:HRP1(YOL123W)|FD-Score:-3.11|P-value:9.47E-4|Clearance:0||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:IMP3(YHR148W)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.43||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:IMP4(YNL075W)|FD-Score:3.28|P-value:5.19E-4|Clearance:0.01||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:KRR1(YCL059C)|FD-Score:-4.18|P-value:1.47E-5|Clearance:0||SGD DESC:Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit Gene:MPS2(YGL075C)|FD-Score:-3.35|P-value:4.00E-4|Clearance:0||SGD DESC:Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p Gene:RIO2(YNL207W)|FD-Score:4.7|P-value:1.29E-6|Clearance:0.28||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RPC11(YDR045C)|FD-Score:-5.3|P-value:5.95E-8|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPC31(YNL151C)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.07||SGD DESC:RNA polymerase III subunit C31 Gene:RPC40(YPR110C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.2||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPL10(YLR075W)|FD-Score:5.92|P-value:1.60E-9|Clearance:0.56||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPN9(YDR427W)|FD-Score:-4.1|P-value:2.11E-5|Clearance:0||SGD DESC:Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress Gene:RRP9(YPR137W)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.13||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC11(YIR022W)|FD-Score:3.8|P-value:7.37E-5|Clearance:0.17||SGD DESC:18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum Gene:TIM10(YHR005C-A)|FD-Score:5.11|P-value:1.62E-7|Clearance:0.41||SGD DESC:Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane Gene:TRS31(YDR472W)|FD-Score:5.36|P-value:4.23E-8|Clearance:0.25||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:TUB1(YML085C)|FD-Score:4.42|P-value:4.88E-6|Clearance:0||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:-3.15|P-value:8.20E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YLR076C(YLR076C_d)|FD-Score:6.56|P-value:2.63E-11|Clearance:0.64||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YOR102W(YOR102W_d)|FD-Score:4.42|P-value:4.91E-6|Clearance:0.19||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:YOR203W(YOR203W_d)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation Gene:YPL044C(YPL044C_d)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W Gene:YRB1(YDR002W)|FD-Score:3.14|P-value:8.46E-4|Clearance:0.07||SGD DESC:Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 Gene:BBP1(YPL255W)|FD-Score:-3.37|P-value:3.75E-4|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:FMN1(YDR236C)|FD-Score:-5.33|P-value:4.84E-8|Clearance:0||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:HRP1(YOL123W)|FD-Score:-3.11|P-value:9.47E-4|Clearance:0||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:IMP3(YHR148W)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.43||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:IMP4(YNL075W)|FD-Score:3.28|P-value:5.19E-4|Clearance:0.01||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:KRR1(YCL059C)|FD-Score:-4.18|P-value:1.47E-5|Clearance:0||SGD DESC:Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit Gene:MPS2(YGL075C)|FD-Score:-3.35|P-value:4.00E-4|Clearance:0||SGD DESC:Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p Gene:RIO2(YNL207W)|FD-Score:4.7|P-value:1.29E-6|Clearance:0.28||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RPC11(YDR045C)|FD-Score:-5.3|P-value:5.95E-8|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPC31(YNL151C)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.07||SGD DESC:RNA polymerase III subunit C31 Gene:RPC40(YPR110C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.2||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPL10(YLR075W)|FD-Score:5.92|P-value:1.60E-9|Clearance:0.56||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPN9(YDR427W)|FD-Score:-4.1|P-value:2.11E-5|Clearance:0||SGD DESC:Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress Gene:RRP9(YPR137W)|FD-Score:3.27|P-value:5.35E-4|Clearance:0.13||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC11(YIR022W)|FD-Score:3.8|P-value:7.37E-5|Clearance:0.17||SGD DESC:18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum Gene:TIM10(YHR005C-A)|FD-Score:5.11|P-value:1.62E-7|Clearance:0.41||SGD DESC:Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane Gene:TRS31(YDR472W)|FD-Score:5.36|P-value:4.23E-8|Clearance:0.25||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:TUB1(YML085C)|FD-Score:4.42|P-value:4.88E-6|Clearance:0||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:-3.15|P-value:8.20E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YLR076C(YLR076C_d)|FD-Score:6.56|P-value:2.63E-11|Clearance:0.64||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YOR102W(YOR102W_d)|FD-Score:4.42|P-value:4.91E-6|Clearance:0.19||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:YOR203W(YOR203W_d)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation Gene:YPL044C(YPL044C_d)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W Gene:YRB1(YDR002W)|FD-Score:3.14|P-value:8.46E-4|Clearance:0.07||SGD DESC:Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 43912568
Download HOP data (tab-delimited text)  (excel)
Gene:ABZ2(YMR289W)|FD-Score:-4.34|P-value:6.97E-6||SGD DESC:Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis Gene:ADE8(YDR408C)|FD-Score:-3.29|P-value:5.01E-4||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ADH4(YGL256W)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency Gene:ARG8(YOL140W)|FD-Score:-4.51|P-value:3.29E-6||SGD DESC:Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine Gene:ATP17(YDR377W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:ATX1(YNL259C)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake Gene:BIO2(YGR286C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:BOR1(YNL275W)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 Gene:BUD19(YJL188C_d)|FD-Score:-4.32|P-value:7.66E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUD30(YDL151C_d)|FD-Score:4.71|P-value:1.27E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CBT1(YKL208W)|FD-Score:-3.79|P-value:7.60E-5||SGD DESC:Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p Gene:CDC26(YFR036W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CMR3(YPR013C_p)|FD-Score:5.13|P-value:1.43E-7||SGD DESC:Putative zinc finger protein; YPR013C is not an essential gene Gene:CNN1(YFR046C)|FD-Score:-4.49|P-value:3.55E-6||SGD DESC:Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T Gene:CTF8(YHR191C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CWP1(YKL096W)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance Gene:DFG5(YMR238W)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:DYN2(YDR424C)|FD-Score:-4.37|P-value:6.30E-6||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:EDS1(YBR033W_p)|FD-Score:6.87|P-value:3.24E-12||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ERG5(YMR015C)|FD-Score:3.19|P-value:7.24E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERI1(YPL096C-A)|FD-Score:-3.19|P-value:7.02E-4||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:ETR1(YBR026C)|FD-Score:-3.91|P-value:4.62E-5||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FLO1(YAR050W)|FD-Score:-3.57|P-value:1.77E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:GCN4(YEL009C)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GCV3(YAL044C)|FD-Score:-3.26|P-value:5.50E-4||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:GRX7(YBR014C)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:-3.77|P-value:8.22E-5||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:HTZ1(YOL012C)|FD-Score:-5.18|P-value:1.08E-7||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:IES1(YFL013C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:IMG1(YCR046C)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:IMG2(YCR071C)|FD-Score:7.26|P-value:1.95E-13||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IRC13(YOR235W_d)|FD-Score:4.53|P-value:2.95E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:JIP4(YDR475C)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence Gene:MAC1(YMR021C)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAK31(YCR020C-A)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MAL13(YGR288W)|FD-Score:3.13|P-value:8.62E-4||SGD DESC:MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C Gene:MBA1(YBR185C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:MGM101(YJR144W)|FD-Score:3.76|P-value:8.62E-5||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MGR1(YCL044C)|FD-Score:-5.14|P-value:1.34E-7||SGD DESC:Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA Gene:MPT5(YGL178W)|FD-Score:5.22|P-value:9.13E-8||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MRC1(YCL061C)|FD-Score:4.8|P-value:8.11E-7||SGD DESC:S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres Gene:NBA1(YOL070C)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate Gene:NCL1(YBL024W)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 Gene:NMA2(YGR010W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:NUP133(YKR082W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:NUP2(YLR335W)|FD-Score:-5.47|P-value:2.28E-8||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PAU11(YGL261C_p)|FD-Score:-3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 Gene:PCD1(YLR151C)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member Gene:PEX18(YHR160C)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PEX28(YHR150W)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PEX32(YBR168W)|FD-Score:4.91|P-value:4.66E-7||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:PFK2(YMR205C)|FD-Score:3.11|P-value:9.26E-4||SGD DESC:Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PKP1(YIL042C)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p Gene:PRK1(YIL095W)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication Gene:PTC6(YCR079W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase Gene:PYK2(YOR347C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication Gene:RBD2(YPL246C)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p Gene:RIM13(YMR154C)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RPL24B(YGR148C)|FD-Score:3.15|P-value:8.20E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPS11B(YBR048W)|FD-Score:3.83|P-value:6.42E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RRT14(YIL127C_p)|FD-Score:-3.11|P-value:9.29E-4||SGD DESC:Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:RSC2(YLR357W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance Gene:RUD3(YOR216C)|FD-Score:5.88|P-value:2.04E-9||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:SCJ1(YMR214W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SCS22(YBL091C-A)|FD-Score:-3.96|P-value:3.69E-5||SGD DESC:Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication Gene:SDC25(YLL016W)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Gene:SDS23(YGL056C)|FD-Score:-3.17|P-value:7.68E-4||SGD DESC:One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication Gene:SER33(YIL074C)|FD-Score:-3.42|P-value:3.15E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:6.07|P-value:6.42E-10||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SOL4(YGR248W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:SPO21(YOL091W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation Gene:SPS100(YHR139C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SRB2(YHR041C)|FD-Score:-3.16|P-value:7.98E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance Gene:SSN2(YDR443C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:STV1(YMR054W)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole Gene:SUS1(YBR111W-A)|FD-Score:4.28|P-value:9.50E-6||SGD DESC:Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP Gene:TCM62(YBR044C)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone Gene:TDA4(YJR116W_p)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele Gene:TOS4(YLR183C)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:VAM6(YDL077C)|FD-Score:4.32|P-value:7.68E-6||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VAN1(YML115C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VEL1(YGL258W)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:VNX1(YNL321W)|FD-Score:-4.66|P-value:1.55E-6||SGD DESC:Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate Gene:VPS25(YJR102C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YAP1802(YGR241C)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication Gene:YBL071C-B(YBL071C-B_p)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR016W(YBR016W)|FD-Score:4.45|P-value:4.20E-6||SGD DESC:Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication Gene:YBR056W(YBR056W_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR072C-A(YBR072C-A_p)|FD-Score:5.38|P-value:3.70E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR139W(YBR139W)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner Gene:YBR238C(YBR238C)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YCL075W(YCL075W)|FD-Score:5.06|P-value:2.10E-7||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Putative protein of unknown function Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.9|P-value:4.72E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR290W(YGR290W_d)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Gene:YHL042W(YHL042W_p)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:YIA6(YIL006W)|FD-Score:5.63|P-value:8.98E-9||SGD DESC:Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs Gene:YKL169C(YKL169C_d)|FD-Score:-3.1|P-value:9.62E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Gene:YML003W(YML003W_p)|FD-Score:-3.15|P-value:8.08E-4||SGD DESC:Putative protein of unknown function Gene:YMR086C-A(YMR086C-A_d)|FD-Score:5.59|P-value:1.16E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR265C(YMR265C_p)|FD-Score:-4.05|P-value:2.62E-5||SGD DESC:Putative protein of unknown function Gene:YMR306C-A(YMR306C-A_d)|FD-Score:3.86|P-value:5.66E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL089C(YNL089C_d)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Gene:YNR040W(YNR040W_p)|FD-Score:-3.22|P-value:6.32E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR325W(YOR325W_d)|FD-Score:-5.7|P-value:6.13E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YOR365C(YOR365C_p)|FD-Score:4.39|P-value:5.67E-6||SGD DESC:Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication Gene:YPL025C(YPL025C_d)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPL035C(YPL035C_d)|FD-Score:6.19|P-value:2.95E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL199C(YPL199C_p)|FD-Score:3.27|P-value:5.46E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YPS6(YIR039C)|FD-Score:3.76|P-value:8.50E-5||SGD DESC:Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance Gene:ABZ2(YMR289W)|FD-Score:-4.34|P-value:6.97E-6||SGD DESC:Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis Gene:ADE8(YDR408C)|FD-Score:-3.29|P-value:5.01E-4||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ADH4(YGL256W)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency Gene:ARG8(YOL140W)|FD-Score:-4.51|P-value:3.29E-6||SGD DESC:Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine Gene:ATP17(YDR377W)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:ATX1(YNL259C)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake Gene:BIO2(YGR286C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:BOR1(YNL275W)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 Gene:BUD19(YJL188C_d)|FD-Score:-4.32|P-value:7.66E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUD30(YDL151C_d)|FD-Score:4.71|P-value:1.27E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CBT1(YKL208W)|FD-Score:-3.79|P-value:7.60E-5||SGD DESC:Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p Gene:CDC26(YFR036W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CMR3(YPR013C_p)|FD-Score:5.13|P-value:1.43E-7||SGD DESC:Putative zinc finger protein; YPR013C is not an essential gene Gene:CNN1(YFR046C)|FD-Score:-4.49|P-value:3.55E-6||SGD DESC:Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T Gene:CTF8(YHR191C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CWP1(YKL096W)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance Gene:DFG5(YMR238W)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:DYN2(YDR424C)|FD-Score:-4.37|P-value:6.30E-6||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:EDS1(YBR033W_p)|FD-Score:6.87|P-value:3.24E-12||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ERG5(YMR015C)|FD-Score:3.19|P-value:7.24E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERI1(YPL096C-A)|FD-Score:-3.19|P-value:7.02E-4||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:ETR1(YBR026C)|FD-Score:-3.91|P-value:4.62E-5||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FLO1(YAR050W)|FD-Score:-3.57|P-value:1.77E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:GCN4(YEL009C)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GCV3(YAL044C)|FD-Score:-3.26|P-value:5.50E-4||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:GRX7(YBR014C)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:-3.77|P-value:8.22E-5||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:HTZ1(YOL012C)|FD-Score:-5.18|P-value:1.08E-7||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:IES1(YFL013C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:IMG1(YCR046C)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:IMG2(YCR071C)|FD-Score:7.26|P-value:1.95E-13||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IRC13(YOR235W_d)|FD-Score:4.53|P-value:2.95E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:JIP4(YDR475C)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence Gene:MAC1(YMR021C)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAK31(YCR020C-A)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MAL13(YGR288W)|FD-Score:3.13|P-value:8.62E-4||SGD DESC:MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C Gene:MBA1(YBR185C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:MGM101(YJR144W)|FD-Score:3.76|P-value:8.62E-5||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MGR1(YCL044C)|FD-Score:-5.14|P-value:1.34E-7||SGD DESC:Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA Gene:MPT5(YGL178W)|FD-Score:5.22|P-value:9.13E-8||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MRC1(YCL061C)|FD-Score:4.8|P-value:8.11E-7||SGD DESC:S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres Gene:NBA1(YOL070C)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate Gene:NCL1(YBL024W)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 Gene:NMA2(YGR010W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:NUP133(YKR082W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:NUP2(YLR335W)|FD-Score:-5.47|P-value:2.28E-8||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PAU11(YGL261C_p)|FD-Score:-3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 Gene:PCD1(YLR151C)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member Gene:PEX18(YHR160C)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PEX28(YHR150W)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PEX32(YBR168W)|FD-Score:4.91|P-value:4.66E-7||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:PFK2(YMR205C)|FD-Score:3.11|P-value:9.26E-4||SGD DESC:Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PKP1(YIL042C)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p Gene:PRK1(YIL095W)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication Gene:PTC6(YCR079W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase Gene:PYK2(YOR347C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication Gene:RBD2(YPL246C)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p Gene:RIM13(YMR154C)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RPL24B(YGR148C)|FD-Score:3.15|P-value:8.20E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPS11B(YBR048W)|FD-Score:3.83|P-value:6.42E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RRT14(YIL127C_p)|FD-Score:-3.11|P-value:9.29E-4||SGD DESC:Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:RSC2(YLR357W)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance Gene:RUD3(YOR216C)|FD-Score:5.88|P-value:2.04E-9||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:SCJ1(YMR214W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SCS22(YBL091C-A)|FD-Score:-3.96|P-value:3.69E-5||SGD DESC:Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication Gene:SDC25(YLL016W)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Gene:SDS23(YGL056C)|FD-Score:-3.17|P-value:7.68E-4||SGD DESC:One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication Gene:SER33(YIL074C)|FD-Score:-3.42|P-value:3.15E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:6.07|P-value:6.42E-10||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SOL4(YGR248W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:SPO21(YOL091W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation Gene:SPS100(YHR139C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SRB2(YHR041C)|FD-Score:-3.16|P-value:7.98E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance Gene:SSN2(YDR443C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:STV1(YMR054W)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole Gene:SUS1(YBR111W-A)|FD-Score:4.28|P-value:9.50E-6||SGD DESC:Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP Gene:TCM62(YBR044C)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone Gene:TDA4(YJR116W_p)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele Gene:TOS4(YLR183C)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:VAM6(YDL077C)|FD-Score:4.32|P-value:7.68E-6||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VAN1(YML115C)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VEL1(YGL258W)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:VNX1(YNL321W)|FD-Score:-4.66|P-value:1.55E-6||SGD DESC:Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate Gene:VPS25(YJR102C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YAP1802(YGR241C)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication Gene:YBL071C-B(YBL071C-B_p)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR016W(YBR016W)|FD-Score:4.45|P-value:4.20E-6||SGD DESC:Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication Gene:YBR056W(YBR056W_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR072C-A(YBR072C-A_p)|FD-Score:5.38|P-value:3.70E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR139W(YBR139W)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner Gene:YBR238C(YBR238C)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YCL075W(YCL075W)|FD-Score:5.06|P-value:2.10E-7||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Putative protein of unknown function Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.9|P-value:4.72E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR290W(YGR290W_d)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Gene:YHL042W(YHL042W_p)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:YIA6(YIL006W)|FD-Score:5.63|P-value:8.98E-9||SGD DESC:Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs Gene:YKL169C(YKL169C_d)|FD-Score:-3.1|P-value:9.62E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Gene:YML003W(YML003W_p)|FD-Score:-3.15|P-value:8.08E-4||SGD DESC:Putative protein of unknown function Gene:YMR086C-A(YMR086C-A_d)|FD-Score:5.59|P-value:1.16E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR265C(YMR265C_p)|FD-Score:-4.05|P-value:2.62E-5||SGD DESC:Putative protein of unknown function Gene:YMR306C-A(YMR306C-A_d)|FD-Score:3.86|P-value:5.66E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL089C(YNL089C_d)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Gene:YNR040W(YNR040W_p)|FD-Score:-3.22|P-value:6.32E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR325W(YOR325W_d)|FD-Score:-5.7|P-value:6.13E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YOR365C(YOR365C_p)|FD-Score:4.39|P-value:5.67E-6||SGD DESC:Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication Gene:YPL025C(YPL025C_d)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPL035C(YPL035C_d)|FD-Score:6.19|P-value:2.95E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL199C(YPL199C_p)|FD-Score:3.27|P-value:5.46E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YPS6(YIR039C)|FD-Score:3.76|P-value:8.50E-5||SGD DESC:Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR076C_d6.562.63E-110.64YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YLR075W5.921.60E-90.56RPL10Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
YDR472W5.364.23E-80.25TRS31One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YHR005C-A5.111.62E-70.41TIM10Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YNL207W4.701.29E-60.28RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YML085C4.424.88E-60.00TUB1Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
YOR102W_d4.424.91E-60.19YOR102W_dDubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
YHR148W4.231.18E-50.43IMP3Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YIR022W3.807.37E-50.17SEC1118kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
YPL044C_d3.631.42E-40.08YPL044C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
YNL151C3.551.91E-40.07RPC31RNA polymerase III subunit C31
YPR110C3.482.50E-40.20RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YNL075W3.285.19E-40.01IMP4Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YPR137W3.275.35E-40.13RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YDR002W3.148.46E-40.07YRB1Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR071C7.261.95E-13IMG2Mitochondrial ribosomal protein of the large subunit
YBR033W_p6.873.24E-12EDS1_pPutative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication
YPL035C_d6.192.95E-10YPL035C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
YPR198W6.076.42E-10SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YOR216C5.882.04E-9RUD3Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
YIL006W5.638.98E-9YIA6Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
YMR086C-A_d5.591.16E-8YMR086C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR072C-A_p5.383.70E-8YBR072C-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YGL178W5.229.13E-8MPT5mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
YPR013C_p5.131.43E-7CMR3_pPutative zinc finger protein; YPR013C is not an essential gene
YCL075W5.062.10E-7YCL075WPseudogene: encodes fragment of Ty Pol protein
YBR168W4.914.66E-7PEX32Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YCL061C4.808.11E-7MRC1S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
YDL151C_d4.711.27E-6BUD30_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YOR235W_d4.532.95E-6IRC13_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci

GO enrichment analysis for SGTC_2927
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0731.90E-8SGTC_1050111-0055 734.8 μMChemDiv (Drug-like library)51793700.0517241
0.0699.77E-8SGTC_29237992654 58.1 μMChembridge (Drug-like library)29851260.0857143Golgi
0.0612.31E-6SGTC_484loperamide 105.0 μMMiscellaneous39550.075
0.0571.10E-5SGTC_31299127257 49.5 μMChembridge (Drug-like library)8378940.106061
0.0571.31E-5SGTC_29117942208 15.6 μMChembridge (Drug-like library)12433840.117647mitochondrial response to ROS
0.0543.16E-5SGTC_8890919-1524 82.7 μMChemDiv (Drug-like library)39054520.0972222
0.0543.31E-5SGTC_1823448-4371 550.5 μMChemDiv (Drug-like library)34914030.106667
0.0543.50E-5SGTC_655k060-0012 42.0 μMChemDiv (Drug-like library)59945250.0666667
0.0534.68E-5SGTC_13973532-0190 20.1 μMChemDiv (Drug-like library)53222800.0769231
0.0526.05E-5SGTC_32459134821 49.5 μMChembridge (Drug-like library)170149010.0810811
0.0526.43E-5SGTC_33309141424 71.4 μMChembridge (Drug-like library)272610200.0909091amide catabolism
0.0518.18E-5SGTC_29649083345 53.4 μMChembridge (Drug-like library)177415790.0923077
0.0491.49E-4SGTC_7911348-1292 225.0 μMChemDiv (Drug-like library)54370540.151899
0.0482.27E-4SGTC_1543389-1638 511.1 μMChemDiv (Drug-like library)52386860.0617284
0.0464.09E-4SGTC_501nsc-95397 161.0 μMICCB bioactive library2620930.127273

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3323913856453.92 μM0.36363643912313Chembridge (Drug-like library)263.290622.94312
SGTC_20545233173129 μM0.3191496889Chembridge (Fragment library)226.026861.41812mitochondrial response to ROS
SGTC_3354077-025627.6 μM0.2686573121989ChemDiv (Drug-like library)363.27213.69404
SGTC_1467k284-1082293 μM0.2666673334705ChemDiv (Drug-like library)273.376543.5222
SGTC_2834900175558.44 μM0.2656252989575Chembridge (Drug-like library)376.289163.28215
SGTC_13241418-002634.4 μM0.2631581372513ChemDiv (Drug-like library)394.06073.79712
SGTC_10543429-0080167 μM0.2537311162877ChemDiv (Drug-like library)399.281063.20113
SGTC_21365328288199.3 μM0.25262395Chembridge (Fragment library)222.220540.81724
SGTC_2995906776771.43 μM0.24193511673567Chembridge (Drug-like library)280.773123.18222
SGTC_2065522159634.26 μM0.240741788581Chembridge (Fragment library)238.286141.71724