Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YKR071C | 5.78 | 3.66E-9 | 1.14 | DRE2 | Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress |
YBL074C | 5.16 | 1.26E-7 | 1.14 | AAR2 | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
YMR079W | 4.02 | 2.96E-5 | 0.12 | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
YOR218C_d | 3.89 | 4.92E-5 | 0.05 | YOR218C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W |
YDL163W_d | 3.84 | 6.13E-5 | 0.24 | YDL163W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase |
YKL082C | 3.60 | 1.56E-4 | 0.49 | RRP14 | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family |
YLR175W | 3.12 | 9.14E-4 | 0.16 | CBF5 | Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita |
YGL120C | 2.96 | 0.00156 | 0.00 | PRP43 | RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome |
YFR031C | 2.95 | 0.00158 | 0.05 | SMC2 | Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus |
YML046W | 2.90 | 0.00189 | 0.01 | PRP39 | U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats |
YNR017W | 2.89 | 0.00192 | 0.03 | TIM23 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel |
YOR122C | 2.86 | 0.00214 | 0.09 | PFY1 | Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress |
YDR301W | 2.76 | 0.00287 | 0.07 | CFT1 | RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF |
YDR280W | 2.70 | 0.00349 | 0.04 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YDR464W | 2.65 | 0.00398 | 0.01 | SPP41 | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |