| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR323C | 9.14 | 3.07E-20 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| YLR417W | 7.84 | 2.18E-15 | VPS36 | Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome |
| YDL118W_p | 7.26 | 1.96E-13 | YDL118W_p | Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein |
| YOR030W | 7.01 | 1.18E-12 | DFG16 | Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p |
| YJR102C | 6.94 | 2.02E-12 | VPS25 | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome |
| YMR063W | 6.73 | 8.22E-12 | RIM9 | Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; |
| YDR415C_p | 6.71 | 9.86E-12 | YDR415C_p | Putative aminopeptidase |
| YMR154C | 5.89 | 1.95E-9 | RIM13 | Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB |
| YKL126W | 5.87 | 2.14E-9 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
| YMR077C | 5.84 | 2.67E-9 | VPS20 | Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes |
| YFR015C | 5.53 | 1.57E-8 | GSY1 | Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
| YML086C | 5.39 | 3.57E-8 | ALO1 | D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress |
| YDR528W | 5.34 | 4.71E-8 | HLR1 | Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication |
| YLR053C_p | 5.32 | 5.15E-8 | YLR053C_p | Putative protein of unknown function |
| YDR247W | 4.98 | 3.10E-7 | VHS1 | Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p |
