Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR329C | 6.43 | 6.40E-11 | 1.06 | SCD5 | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
YKL082C | 5.37 | 3.91E-8 | 0.77 | RRP14 | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family |
YOR370C | 4.60 | 2.14E-6 | 0.60 | MRS6 | Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress |
YNR003C | 3.99 | 3.25E-5 | 0.15 | RPC34 | RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex |
YGL122C | 3.84 | 6.18E-5 | 0.24 | NAB2 | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress |
YML046W | 3.60 | 1.61E-4 | 0.09 | PRP39 | U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats |
YML049C | 3.50 | 2.30E-4 | 0.03 | RSE1 | Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport |
YGL091C | 3.47 | 2.61E-4 | 0.15 | NBP35 | Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases |
YKL189W | 3.32 | 4.47E-4 | 0.08 | HYM1 | Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response |
YCR035C | 3.25 | 5.85E-4 | 0.07 | RRP43 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress |
YDR160W | 3.17 | 7.52E-4 | 0.05 | SSY1 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YMR268C | 3.13 | 8.80E-4 | 0.07 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YPL237W | 3.06 | 0.00112 | 0.07 | SUI3 | Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding |
YML010W | 2.98 | 0.00144 | 0.02 | SPT5 | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair |
YDR054C | 2.96 | 0.00154 | 0.18 | CDC34 | Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress |