9076800

N-(3,4-dimethylphenyl)-2-(4-ethyl-2-oxomorpholin-3-yl)acetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2957
Screen concentration 11.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16459615
SMILES CCN1CCOC(=O)C1CC(=O)NC2=CC(=C(C=C2)C)C
Standardized SMILES CCN1CCOC(=O)C1CC(=O)Nc2ccc(C)c(C)c2
Molecular weight 290.3575
ALogP 2.19
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.27
% growth inhibition (Hom. pool) 6.9


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16459615
Download HIP data (tab-delimited text)  (excel)
Gene:AME1(YBR211C)|FD-Score:3.23|P-value:6.09E-4|Clearance:0.06||SGD DESC:Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress Gene:ARH1(YDR376W)|FD-Score:4.69|P-value:1.39E-6|Clearance:0.4||SGD DESC:Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability Gene:GPI8(YDR331W)|FD-Score:3.7|P-value:1.08E-4|Clearance:0.16||SGD DESC:ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog Gene:HEM12(YDR047W)|FD-Score:-3.49|P-value:2.44E-4|Clearance:0||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:KOG1(YHR186C)|FD-Score:-3.24|P-value:5.99E-4|Clearance:0||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:LAS17(YOR181W)|FD-Score:-3.16|P-value:7.83E-4|Clearance:0||SGD DESC:Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) Gene:NHP2(YDL208W)|FD-Score:-3.52|P-value:2.14E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NUF2(YOL069W)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.03||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:NUP159(YIL115C)|FD-Score:-3.59|P-value:1.67E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:PSF1(YDR013W)|FD-Score:-4.17|P-value:1.53E-5|Clearance:0||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:RNA1(YMR235C)|FD-Score:-3.18|P-value:7.41E-4|Clearance:0||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RPC53(YDL150W)|FD-Score:3.39|P-value:3.53E-4|Clearance:0.15||SGD DESC:RNA polymerase III subunit C53 Gene:RPL3(YOR063W)|FD-Score:-3.67|P-value:1.20E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus Gene:RPO31(YOR116C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPS13(YDR064W)|FD-Score:-3.18|P-value:7.43E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:SRP101(YDR292C)|FD-Score:3.82|P-value:6.76E-5|Clearance:0.02||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SSL1(YLR005W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.14||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:SUP45(YBR143C)|FD-Score:3.8|P-value:7.19E-5|Clearance:0.1||SGD DESC:Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p Gene:SWI1(YPL016W)|FD-Score:4.29|P-value:9.09E-6|Clearance:0.32||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:TFC4(YGR047C)|FD-Score:3.17|P-value:7.62E-4|Clearance:0.07||SGD DESC:One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 Gene:TIF6(YPR016C)|FD-Score:3.51|P-value:2.20E-4|Clearance:0.13||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOA2(YKL058W)|FD-Score:3.96|P-value:3.71E-5|Clearance:0.15||SGD DESC:TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress Gene:UTP20(YBL004W)|FD-Score:-4.46|P-value:4.01E-6|Clearance:0||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:YNL247W(YNL247W)|FD-Score:-3.61|P-value:1.52E-4|Clearance:0||SGD DESC:Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments Gene:AME1(YBR211C)|FD-Score:3.23|P-value:6.09E-4|Clearance:0.06||SGD DESC:Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress Gene:ARH1(YDR376W)|FD-Score:4.69|P-value:1.39E-6|Clearance:0.4||SGD DESC:Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability Gene:GPI8(YDR331W)|FD-Score:3.7|P-value:1.08E-4|Clearance:0.16||SGD DESC:ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog Gene:HEM12(YDR047W)|FD-Score:-3.49|P-value:2.44E-4|Clearance:0||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:KOG1(YHR186C)|FD-Score:-3.24|P-value:5.99E-4|Clearance:0||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:LAS17(YOR181W)|FD-Score:-3.16|P-value:7.83E-4|Clearance:0||SGD DESC:Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) Gene:NHP2(YDL208W)|FD-Score:-3.52|P-value:2.14E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NUF2(YOL069W)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.03||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:NUP159(YIL115C)|FD-Score:-3.59|P-value:1.67E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:PSF1(YDR013W)|FD-Score:-4.17|P-value:1.53E-5|Clearance:0||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:RNA1(YMR235C)|FD-Score:-3.18|P-value:7.41E-4|Clearance:0||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RPC53(YDL150W)|FD-Score:3.39|P-value:3.53E-4|Clearance:0.15||SGD DESC:RNA polymerase III subunit C53 Gene:RPL3(YOR063W)|FD-Score:-3.67|P-value:1.20E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus Gene:RPO31(YOR116C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPS13(YDR064W)|FD-Score:-3.18|P-value:7.43E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:SRP101(YDR292C)|FD-Score:3.82|P-value:6.76E-5|Clearance:0.02||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SSL1(YLR005W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.14||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:SUP45(YBR143C)|FD-Score:3.8|P-value:7.19E-5|Clearance:0.1||SGD DESC:Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p Gene:SWI1(YPL016W)|FD-Score:4.29|P-value:9.09E-6|Clearance:0.32||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:TFC4(YGR047C)|FD-Score:3.17|P-value:7.62E-4|Clearance:0.07||SGD DESC:One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 Gene:TIF6(YPR016C)|FD-Score:3.51|P-value:2.20E-4|Clearance:0.13||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOA2(YKL058W)|FD-Score:3.96|P-value:3.71E-5|Clearance:0.15||SGD DESC:TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress Gene:UTP20(YBL004W)|FD-Score:-4.46|P-value:4.01E-6|Clearance:0||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:YNL247W(YNL247W)|FD-Score:-3.61|P-value:1.52E-4|Clearance:0||SGD DESC:Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16459615
Download HOP data (tab-delimited text)  (excel)
Gene:AHA1(YDR214W)|FD-Score:4.42|P-value:4.98E-6||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM33(YML087C)|FD-Score:10.1|P-value:3.31E-24||SGD DESC:Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication Gene:ARC18(YLR370C)|FD-Score:4.8|P-value:7.83E-7||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:ARR1(YPR199C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds Gene:ATG23(YLR431C)|FD-Score:5.35|P-value:4.33E-8||SGD DESC:Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p Gene:BLI1(YKL061W_p)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:CCE1(YKL011C)|FD-Score:4.79|P-value:8.17E-7||SGD DESC:Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA Gene:CLB4(YLR210W)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation Gene:CPR7(YJR032W)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CRP1(YHR146W)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Protein that binds to cruciform DNA structures Gene:CTF8(YHR191C)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:DIA3(YDL024C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DTD1(YDL219W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:EMI2(YDR516C)|FD-Score:-4.64|P-value:1.77E-6||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:FLO10(YKR102W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth Gene:FOX2(YKR009C)|FD-Score:-3.94|P-value:4.14E-5||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:FRT2(YAL028W)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication Gene:GBP2(YCL011C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GLO2(YDR272W)|FD-Score:4.48|P-value:3.79E-6||SGD DESC:Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate Gene:HIR3(YJR140C)|FD-Score:4.75|P-value:1.00E-6||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HOM2(YDR158W)|FD-Score:5.65|P-value:8.13E-9||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HPA3(YEL066W)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro Gene:ICY2(YPL250C)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate Gene:IES6(YEL044W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes Gene:IMG1(YCR046C)|FD-Score:4.97|P-value:3.39E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:IPT1(YDR072C)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin Gene:MAK32(YCR019W)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MMS1(YPR164W)|FD-Score:-3.28|P-value:5.12E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay Gene:MNN1(YER001W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family Gene:MRK1(YDL079C)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation Gene:MSN4(YKL062W)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:MUP1(YGR055W)|FD-Score:-3.34|P-value:4.17E-4||SGD DESC:High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake Gene:MXR2(YCL033C)|FD-Score:-5.74|P-value:4.87E-9||SGD DESC:Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan Gene:NPL3(YDR432W)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:NUM1(YDR150W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:NUP60(YAR002W)|FD-Score:5.87|P-value:2.16E-9||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OSW1(YOR255W)|FD-Score:8.42|P-value:1.84E-17||SGD DESC:Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p Gene:PDC6(YGR087C)|FD-Score:-3.91|P-value:4.60E-5||SGD DESC:Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation Gene:PET127(YOR017W)|FD-Score:-3.58|P-value:1.73E-4||SGD DESC:Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane Gene:PFD1(YJL179W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PFK26(YIL107C)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A Gene:PHO90(YJL198W)|FD-Score:3.77|P-value:8.21E-5||SGD DESC:Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication Gene:PIG1(YLR273C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase Gene:PPZ2(YDR436W)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Gene:PUT2(YHR037W)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:QRI5(YLR204W)|FD-Score:4.79|P-value:8.31E-7||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RPL17B(YJL177W)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication Gene:RTT109(YLL002W)|FD-Score:6.5|P-value:4.12E-11||SGD DESC:Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p Gene:SBH1(YER087C-B)|FD-Score:-6.68|P-value:1.19E-11||SGD DESC:Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p Gene:SIS2(YKR072C)|FD-Score:-3.58|P-value:1.71E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SPS100(YHR139C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:STF1(YDL130W-A)|FD-Score:6.44|P-value:5.89E-11||SGD DESC:Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress Gene:SYS1(YJL004C)|FD-Score:-3.86|P-value:5.78E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:SYT1(YPR095C)|FD-Score:-3.12|P-value:9.18E-4||SGD DESC:Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain Gene:TCA17(YEL048C)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:THI3(YDL080C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis Gene:TIF4631(YGR162W)|FD-Score:3.37|P-value:3.72E-4||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:UBX2(YML013W)|FD-Score:-3.73|P-value:9.67E-5||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:VID24(YBR105C)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:VMA9(YCL005W-A)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis Gene:WSC3(YOL105C)|FD-Score:-4.05|P-value:2.58E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:XPT1(YJR133W)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine Gene:YAP3(YHL009C)|FD-Score:-4.61|P-value:1.98E-6||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YBL055C(YBL055C)|FD-Score:-4.84|P-value:6.45E-7||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YCR050C(YCR050C_p)|FD-Score:3.29|P-value:4.99E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL186W(YDL186W_p)|FD-Score:4.51|P-value:3.19E-6||SGD DESC:Putative protein of unknown function; YDL186W is not an essential gene Gene:YDL218W(YDL218W_p)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Gene:YDR209C(YDR209C_d)|FD-Score:-4.54|P-value:2.81E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Gene:YDR379C-A(YDR379C-A)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL028W(YEL028W_d)|FD-Score:-4.04|P-value:2.64E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL034C(YGL034C_d)|FD-Score:6.01|P-value:9.34E-10||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL138C(YGL138C_p)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Putative protein of unknown function; has no significant sequence similarity to any known protein Gene:YGL165C(YGL165C_d)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W Gene:YGR012W(YGR012W)|FD-Score:3.16|P-value:7.93E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YHR202W(YHR202W_p)|FD-Score:3.85|P-value:5.92E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL168W(YIL168W)|FD-Score:-5.1|P-value:1.66E-7||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase Gene:YJL132W(YJL132W_p)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YKR078W(YKR078W)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YKR104W(YKR104W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR173W(YLR173W_p)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Putative protein of unknown function Gene:YLR352W(YLR352W_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene Gene:YNL303W(YNL303W_d)|FD-Score:-3.88|P-value:5.30E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR014W(YNR014W_p)|FD-Score:4.5|P-value:3.39E-6||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YNR064C(YNR064C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YNR071C(YNR071C_p)|FD-Score:-4.59|P-value:2.26E-6||SGD DESC:Putative aldose 1-epimerase Gene:YOL159C-A(YOL159C-A)|FD-Score:-5.37|P-value:3.84E-8||SGD DESC:Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species Gene:YOR019W(YOR019W)|FD-Score:-4.54|P-value:2.79E-6||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YOR097C(YOR097C_p)|FD-Score:-4.77|P-value:9.01E-7||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:AHA1(YDR214W)|FD-Score:4.42|P-value:4.98E-6||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM33(YML087C)|FD-Score:10.1|P-value:3.31E-24||SGD DESC:Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication Gene:ARC18(YLR370C)|FD-Score:4.8|P-value:7.83E-7||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:ARR1(YPR199C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds Gene:ATG23(YLR431C)|FD-Score:5.35|P-value:4.33E-8||SGD DESC:Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p Gene:BLI1(YKL061W_p)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome Gene:CCE1(YKL011C)|FD-Score:4.79|P-value:8.17E-7||SGD DESC:Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA Gene:CLB4(YLR210W)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation Gene:CPR7(YJR032W)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CRP1(YHR146W)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Protein that binds to cruciform DNA structures Gene:CTF8(YHR191C)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:DIA3(YDL024C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DTD1(YDL219W)|FD-Score:-3.34|P-value:4.20E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:EMI2(YDR516C)|FD-Score:-4.64|P-value:1.77E-6||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:FLO10(YKR102W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth Gene:FOX2(YKR009C)|FD-Score:-3.94|P-value:4.14E-5||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:FRT2(YAL028W)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication Gene:GBP2(YCL011C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GLO2(YDR272W)|FD-Score:4.48|P-value:3.79E-6||SGD DESC:Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate Gene:HIR3(YJR140C)|FD-Score:4.75|P-value:1.00E-6||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HOM2(YDR158W)|FD-Score:5.65|P-value:8.13E-9||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HPA3(YEL066W)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro Gene:ICY2(YPL250C)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate Gene:IES6(YEL044W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes Gene:IMG1(YCR046C)|FD-Score:4.97|P-value:3.39E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:IPT1(YDR072C)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin Gene:MAK32(YCR019W)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MMS1(YPR164W)|FD-Score:-3.28|P-value:5.12E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay Gene:MNN1(YER001W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family Gene:MRK1(YDL079C)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation Gene:MSN4(YKL062W)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:MUP1(YGR055W)|FD-Score:-3.34|P-value:4.17E-4||SGD DESC:High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake Gene:MXR2(YCL033C)|FD-Score:-5.74|P-value:4.87E-9||SGD DESC:Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan Gene:NPL3(YDR432W)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:NUM1(YDR150W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:NUP60(YAR002W)|FD-Score:5.87|P-value:2.16E-9||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OSW1(YOR255W)|FD-Score:8.42|P-value:1.84E-17||SGD DESC:Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p Gene:PDC6(YGR087C)|FD-Score:-3.91|P-value:4.60E-5||SGD DESC:Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation Gene:PET127(YOR017W)|FD-Score:-3.58|P-value:1.73E-4||SGD DESC:Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane Gene:PFD1(YJL179W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PFK26(YIL107C)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A Gene:PHO90(YJL198W)|FD-Score:3.77|P-value:8.21E-5||SGD DESC:Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication Gene:PIG1(YLR273C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase Gene:PPZ2(YDR436W)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Gene:PUT2(YHR037W)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:QRI5(YLR204W)|FD-Score:4.79|P-value:8.31E-7||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RPL17B(YJL177W)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication Gene:RTT109(YLL002W)|FD-Score:6.5|P-value:4.12E-11||SGD DESC:Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p Gene:SBH1(YER087C-B)|FD-Score:-6.68|P-value:1.19E-11||SGD DESC:Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p Gene:SIS2(YKR072C)|FD-Score:-3.58|P-value:1.71E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SPS100(YHR139C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:STF1(YDL130W-A)|FD-Score:6.44|P-value:5.89E-11||SGD DESC:Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress Gene:SYS1(YJL004C)|FD-Score:-3.86|P-value:5.78E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:SYT1(YPR095C)|FD-Score:-3.12|P-value:9.18E-4||SGD DESC:Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain Gene:TCA17(YEL048C)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:THI3(YDL080C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis Gene:TIF4631(YGR162W)|FD-Score:3.37|P-value:3.72E-4||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:UBX2(YML013W)|FD-Score:-3.73|P-value:9.67E-5||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:VID24(YBR105C)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:VMA9(YCL005W-A)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis Gene:WSC3(YOL105C)|FD-Score:-4.05|P-value:2.58E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:XPT1(YJR133W)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine Gene:YAP3(YHL009C)|FD-Score:-4.61|P-value:1.98E-6||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YBL055C(YBL055C)|FD-Score:-4.84|P-value:6.45E-7||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YCR050C(YCR050C_p)|FD-Score:3.29|P-value:4.99E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL186W(YDL186W_p)|FD-Score:4.51|P-value:3.19E-6||SGD DESC:Putative protein of unknown function; YDL186W is not an essential gene Gene:YDL218W(YDL218W_p)|FD-Score:-3.67|P-value:1.22E-4||SGD DESC:Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Gene:YDR209C(YDR209C_d)|FD-Score:-4.54|P-value:2.81E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Gene:YDR379C-A(YDR379C-A)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL028W(YEL028W_d)|FD-Score:-4.04|P-value:2.64E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL034C(YGL034C_d)|FD-Score:6.01|P-value:9.34E-10||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL138C(YGL138C_p)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Putative protein of unknown function; has no significant sequence similarity to any known protein Gene:YGL165C(YGL165C_d)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W Gene:YGR012W(YGR012W)|FD-Score:3.16|P-value:7.93E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YHR202W(YHR202W_p)|FD-Score:3.85|P-value:5.92E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL168W(YIL168W)|FD-Score:-5.1|P-value:1.66E-7||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase Gene:YJL132W(YJL132W_p)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YKR078W(YKR078W)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YKR104W(YKR104W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR173W(YLR173W_p)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Putative protein of unknown function Gene:YLR352W(YLR352W_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene Gene:YNL303W(YNL303W_d)|FD-Score:-3.88|P-value:5.30E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR014W(YNR014W_p)|FD-Score:4.5|P-value:3.39E-6||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YNR064C(YNR064C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YNR071C(YNR071C_p)|FD-Score:-4.59|P-value:2.26E-6||SGD DESC:Putative aldose 1-epimerase Gene:YOL159C-A(YOL159C-A)|FD-Score:-5.37|P-value:3.84E-8||SGD DESC:Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species Gene:YOR019W(YOR019W)|FD-Score:-4.54|P-value:2.79E-6||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YOR097C(YOR097C_p)|FD-Score:-4.77|P-value:9.01E-7||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR376W4.691.39E-60.40ARH1Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YPL016W4.299.09E-60.32SWI1Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
YKL058W3.963.71E-50.15TOA2TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
YDR292C3.826.76E-50.02SRP101Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
YBR143C3.807.19E-50.10SUP45Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
YDR331W3.701.08E-40.16GPI8ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YOR116C3.541.98E-40.00RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YOL069W3.542.00E-40.03NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YPR016C3.512.20E-40.13TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YDL150W3.393.53E-40.15RPC53RNA polymerase III subunit C53
YBR211C3.236.09E-40.06AME1Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
YGR047C3.177.62E-40.07TFC4One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
YLR005W3.109.66E-40.14SSL1Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YDR478W2.960.001520.02SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YKL173W2.950.001600.05SNU114GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML087C10.103.31E-24AIM33Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
YOR255W8.421.84E-17OSW1Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YLL002W6.504.12E-11RTT109Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
YDL130W-A6.445.89E-11STF1Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress
YGL034C_d6.019.34E-10YGL034C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR002W5.872.16E-9NUP60FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153
YDR158W5.658.13E-9HOM2Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YLR431C5.354.33E-8ATG23Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YCR046C4.973.39E-7IMG1Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YLR370C4.807.83E-7ARC18Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YKL011C4.798.17E-7CCE1Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
YLR204W4.798.31E-7QRI5Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
YJR140C4.751.00E-6HIR3Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
YBR105C4.592.26E-6VID24GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
YDL186W_p4.513.19E-6YDL186W_pPutative protein of unknown function; YDL186W is not an essential gene

GO enrichment analysis for SGTC_2957
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0714.82E-8SGTC_29629082311 13.2 μMChembridge (Drug-like library)164594530.72549
0.0631.44E-6SGTC_1607st000305 50.6 μMTimTec (Natural product derivative library)54576900.146341
0.0621.81E-6SGTC_1930st074634 34.3 μMTimTec (Natural product derivative library)6842530.114286RNA pol III & RNase P/MRP
0.0621.88E-6SGTC_2537larixol 68.9 μMMicrosource (Natural product library)67087590.060241
0.0622.12E-6SGTC_2738aclarubicin 5.5 μMMiscellaneous4514150.114754RNA pol III & RNase P/MRP
0.0543.47E-5SGTC_2544sphondin 68.5 μMMicrosource (Natural product library)1081040.111111RNA pol III & RNase P/MRP
0.0534.91E-5SGTC_8350312-0010 67.2 μMChemDiv (Drug-like library)16261960.0985916
0.0535.05E-5SGTC_14294049-0205 9.5 μMChemDiv (Drug-like library)227744780.181818
0.0526.71E-5SGTC_1943st076331 65.2 μMTimTec (Natural product derivative library)242084150.0853659
0.0527.47E-5SGTC_32509135583 49.5 μMChembridge (Drug-like library)76993530.157143
0.0491.81E-4SGTC_8540422-0053 192.0 μMChemDiv (Drug-like library)35967280.0657895PDR1
0.0463.66E-4SGTC_23165844804 197.4 μMChembridge (Fragment library)7768130.0810811
0.0464.04E-4SGTC_31789107506 49.5 μMChembridge (Drug-like library)88971940.328358
0.0464.26E-4SGTC_1807st050092 58.9 μMTimTec (Natural product derivative library)50084960.1549360S ribosome export
0.0464.54E-4SGTC_2522biochanin a 4.9 μMMicrosource (Natural product library)52803730.106667RNA pol III & RNase P/MRP

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_296090793895.97 μM0.82352916457355Chembridge (Drug-like library)310.775962.36514
SGTC_331791384958.75 μM0.7517020139Chembridge (Drug-like library)298.2852461.62516
SGTC_2952907373113.78 μM0.7254916457353Chembridge (Drug-like library)296.749381.87814tubulin folding & SWR complex
SGTC_2962908231113.18 μM0.7254916459453Chembridge (Drug-like library)290.357482.15714
SGTC_294790726397.68 μM0.70909116488146Chembridge (Drug-like library)314.7398432.08415tubulin folding & SWR complex
SGTC_3282910849815.46 μM0.70370416459645Chembridge (Drug-like library)280.2947831.4215
SGTC_2958907725416.72 μM0.69811316457351Chembridge (Drug-like library)292.33031.19815
SGTC_295690761962.52 μM0.69230816423868Chembridge (Drug-like library)331.194442.54314
SGTC_296390825079 μM0.68518516459611Chembridge (Drug-like library)306.356881.54715
SGTC_294990725422.23 μM0.66071416457352Chembridge (Drug-like library)354.399682.77415TSC3-RPN4